Improved Treatment of Colorectal Cancer with CF10 Diversity Supplement

CA254834补编项目总结 CA254834的这一少数民族行政副刊请求提供资金，用于培训Charles Chidi Okechukwu 第一阶段STTR项目的翻译目标以及开发新业务开发和 创业技能是支持公司发展的候选人。获得资金支持的第一期科技成果转化项目 (CA254834)重点展示了一种新型FP聚合物CF10在临床前表现出更好的活性 转移性结直肠癌模型(MCRC)目前获得资助的目标是：i)展示CF10抑制CRC 原位结肠癌模型中的转移进展；AD II)显示改善的抗转移活性 CF10在大鼠同基因结直肠癌肝移植模型中的表达。有了补充资金，查尔斯将调查CF10是否会 对获得性5-FU耐药的结直肠癌有效，联合应用可增强疗效 亚叶酸(LV；叶酸)，补充正在进行的研究。补充目标是：S1)演示 CF10在5-FU耐药的原位结直肠癌模型中抗转移活性的改善；以及S2)评估 CF10在5-FU耐药的原位结直肠癌模型中对亚叶酸钙的增强作用查尔斯的指导计划将 包括与临床前药物开发、转化性研究和 企业家精神。培训将包括与研究人员、临床专家和企业进行交流。 发展专家。查尔斯还将接受写作技能方面的指导，包括商业计划开发。 以及演示技巧，包括向投资者演示。培训将促进长期的职业生涯 申请人的机会，包括发展专业网络，并推进 该公司正在将CF10技术商业化。

Project Summary for Supplement to CA254834 This minority administrative supplement to CA254834 requests funds for training Charles Chidi Okechukwu in the translational objectives of the Phase 1 STTR project and developing new business development and entrepreneurial skills fir the candidate that will support company growth. The funded Phase 1 STTR project (CA254834) focuses on demonstrating that a novel FP polymer, CF10, displays improved activity in pre-clinical models of metastatic colorectal cancer (mCRC). Currently funded Aims are: i) Demonstrate CF10 inhibits CRC metastatic progression in an orthotopic colon tumor model; ad ii) Demonstrate improved anti-metastatic activity for CF10 in a rat syngeneic CRC liver met model. With supplement funding, Charles will investigate if CF10 will be effective in treating CRC with acquired resistance to 5-FU and will be potentiated in combination with leucovorin (LV; folinic acid), which complements ongoing studies. The supplemental Aims are: S1) Demonstrate improved anti-metastatic activity for CF10 in 5-FU-resistant orthotopic CRC models; and S2) Evaluate Leucovorin potentiation of CF10 in 5-FU-resistant orthotopic CRC models. The mentoring plan for Charles will include training in technical skills related to pre-clinical drug development, translational research, and entrepreneurship. Training will include interfacing with researchers, clinical experts, and with business development experts. Charles will also receive mentoring in writing skills, including business plan development, and presentation skills, including presentation to investors. Training will enhance the long-term career opportunities of the applicant, including development of a professional network, and advance the goals of the company in commercializing CF10 technology.