Temperature and metabolic compensation mechanisms in a circadian clock system
生物钟系统中的温度和代谢补偿机制
基本信息
- 批准号:10544006
- 负责人:
- 金额:$ 37.85万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2022
- 资助国家:美国
- 起止时间:2022-01-01 至 2026-12-31
- 项目状态:未结题
- 来源:
- 关键词:BehaviorBiochemicalBiologicalBiological ClocksChronobiologyClock proteinCompensationCyanobacteriumEnzymesGoalsHealthKnowledgeLinkMetabolicMethodologyModelingMolecularOrganismOutcomePhenotypePhysiologicalPositioning AttributeSystemTemperatureTimeVariantVisionWorkcircadian pacemakerin vivoinnovationtool
项目摘要
Project Summary/Abstract
Circadian clocks are intracellular enzymatic systems that provide a biochemical
representation of local time with profound consequences to health across diverse
organisms. Unlike most enzymes, biological clocks need to be insensitive to a range
of physiological temperatures and cellular energy levels so that organisms can
anticipate dawn and dusk reliably. However, the mechanisms by which circadian
clocks in any organism achieve insensitivity to temperature (i.e., temperature
compensation) and cellular energy levels (i.e., metabolic compensation) are far from
understood. Therefore, the overall vision of the LiWang lab for the next five years is to
elucidate the mechanisms of temperature compensation and metabolic
compensation in the circadian clock of cyanobacteria. Over the past 20 years, we
have made many impactful discoveries on mechanism of the cyanobacterial clock
and developed innovative methodologies and tools along the way. Thus, we are very
well positioned to succeed at filling critical gaps in knowledge in the field of
biological timekeeping. A major expected outcome of the work proposed here is a
detailed cause-and-effect model linking clock protein behavior and interactions to
temperature and metabolic compensation phenotypes in vivo.
项目摘要/摘要
生物钟是细胞内的酶系统,它提供了一种生化
代表当地时间,对不同地区的健康产生深远影响
有机体。与大多数酶不同,生物钟需要对某一范围不敏感。
生理温度和细胞能量水平,这样生物体可以
可靠地预测黎明和黄昏。然而,昼夜节律的机制
任何生物体中的时钟都对温度(即温度)不敏感
补偿)和细胞能量水平(即新陈代谢补偿)远远不是
明白了。因此,力王实验室未来五年的总体愿景是
阐明温度补偿和代谢的机制
蓝藻生物钟的补偿。在过去的20年里,我们
在蓝藻生物钟的机制上有了许多有影响力的发现
并在此过程中开发了创新的方法和工具。因此,我们非常
处于有利地位,能够成功填补该领域知识的关键空白
生物计时。这里提出的工作的一个主要预期成果是
详细的因果模型将时钟蛋白的行为和相互作用联系起来
体内温度和代谢补偿表型。
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
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Andy LiWang其他文献
Andy LiWang的其他文献
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{{ truncateString('Andy LiWang', 18)}}的其他基金
Temperature and metabolic compensation mechanisms in a circadian clock system
生物钟系统中的温度和代谢补偿机制
- 批准号:
10594727 - 财政年份:2022
- 资助金额:
$ 37.85万 - 项目类别:
Temperature and metabolic compensation mechanisms in a circadian clock system
生物钟系统中的温度和代谢补偿机制
- 批准号:
10797991 - 财政年份:2022
- 资助金额:
$ 37.85万 - 项目类别:
Temperature and metabolic compensation mechanisms in a circadian clock system
生物钟系统中的温度和代谢补偿机制
- 批准号:
10330682 - 财政年份:2022
- 资助金额:
$ 37.85万 - 项目类别:
The Linchpin that Joins the Circadian Oscillator to Clock Output
连接昼夜节律振荡器和时钟输出的关键
- 批准号:
10152597 - 财政年份:2014
- 资助金额:
$ 37.85万 - 项目类别:
The Linchpin that Joins the Circadian Oscillator to Clock Output
连接昼夜节律振荡器和时钟输出的关键
- 批准号:
8846618 - 财政年份:2014
- 资助金额:
$ 37.85万 - 项目类别:
Tertiary Structures of Circadian Clock Proteins by NMR
通过 NMR 观察昼夜节律钟蛋白的三级结构
- 批准号:
6719590 - 财政年份:2002
- 资助金额:
$ 37.85万 - 项目类别:
The Structural and Biochemical Bases of Circadian Oscillator Rhythmicity
昼夜节律振荡器节律的结构和生化基础
- 批准号:
7677075 - 财政年份:2002
- 资助金额:
$ 37.85万 - 项目类别:
Tertiary Structures of Circadian Clock Proteins by NMR
通过 NMR 观察昼夜节律钟蛋白的三级结构
- 批准号:
7048609 - 财政年份:2002
- 资助金额:
$ 37.85万 - 项目类别:
Tertiary Structures of Circadian Clock Proteins by NMR
通过 NMR 观察昼夜节律钟蛋白的三级结构
- 批准号:
6868981 - 财政年份:2002
- 资助金额:
$ 37.85万 - 项目类别:
Tertiary Structures of Circadian Clock Proteins by NMR
通过 NMR 观察昼夜节律钟蛋白的三级结构
- 批准号:
6419683 - 财政年份:2002
- 资助金额:
$ 37.85万 - 项目类别:
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