Reward Processing in Anorexia Nervosa and Avoidant/Restrictive Food Intake: Behavior, DisorderHormonal Concentrations, and Brain Activation in Low-Weight Eating Disorders.

神经性厌食症和回避/限制性食物摄入的奖励处理：低体重饮食障碍中的行为、紊乱荷尔蒙浓度和大脑激活。

• 批准号: 9355469
• 负责人: Kendra R Becker
• 金额: $ 6.12万
• 依托单位: MASSACHUSETTS GENERAL HOSPITAL
• 依托单位国家: 美国
• 财政年份: 2016
• 资助国家: 美国
• 起止时间: 2016-09-15 至 2019-09-14
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9355469
• 关键词: Acute; Adolescent; Affective; Amygdaloid structure; Anorexia Nervosa; Anterior; Behavior; Behavioral; Body Image; Body mass index; Brain; Calories; Candy; Choking; Clinical; Collaborations; Comorbidity; Consumption; DSM-V; Data; Desire for food; Development; Disease; Eating; Eating Behavior; Eating Disorders; Endocrine; Equipment and supply inventories; Expectancy; Fasting; Fatty acid glycerol esters; Food; Foundations; Fright; Functional Magnetic Resonance Imaging; Functional disorder; Funding; Goals; Hormones; Image; Individual; Insula of Reil; Interdisciplinary Study; Intervention; Investigation; Knowledge; Maintenance; Malnutrition; Measures; Medical; Mental Health; Mental disorders; Methodology; Morbidity - disease rate; National Research Service Awards; Neurobiology; Neurosecretory Systems; Nucleus Accumbens; Nutritional; Oxytocin; Palate; Palladium; Patient Self-Report; Psychiatric therapeutic procedure; Psychological reinforcement; Psychopathology; Public Health; Reporting; Research; Research Training; Rewards; Risk; Role; Sensory; Standardization; Starvation; Stimulus; System; Taste Perception; Testing; Training; Treatment Cost; Vegetables; Visual; Vomiting; Weight; Weight maintenance regimen; base; career; career development; design; dietary restriction; disorder control; eating pathology; effective intervention; experience; feeding; food consumption; food restriction; frontal lobe; healthy weight; indexing; innovation; interest; mortality; multidisciplinary; neural circuit; neurobiological mechanism; neuroimaging; novel; physical conditioning; pleasure; preference; programs; response; reward processing; severe mental illness; skills; success; visual stimulus; weight maintenance; young woman

PROJECT SUMMARY/ABSTRACT In this postdoctoral F32 Kirschstein NRSA, Kendra Becker proposes a comprehensive interdisciplinary research and training plan focused on aberrant reward processing underlying two distinct feeding and eating disorders characterized by restrictive eating: anorexia nervosa (AN) and avoidant/restrictive food intake disorder (ARFID). Low-weight eating disorders are associated with substantial medical morbidity, psychiatric comorbidity, increased mortality, and high treatment costs. Kendra’s long-term research program goal is to examine affective maintaining mechanisms of disordered eating across multiple units of analysis for the purpose of understanding reward and reinforcement influences on eating behaviors in order to inform novel targeted interventions. Preliminary findings in AN suggest that disruptions in reward processing may involve preferences for low-calorie foods. No such investigations exist for ARFID. Kendra proposes to compare reward processing of low- and high- calorie food images between AN, ARFID, and controls across three units of analysis: neuroimaging, hormone levels, and behavioral/self-report measures. This innovative proposal examines novel hypotheses by leveraging data from a currently funded R01 (MH103402), featuring measures of eating pathology, brain activation to visual food stimuli, and levels of appetite regulating hormones. In collaboration with her co-sponsors, Drs. Eddy, Thomas, and Lawson, and expert consultants, the applicant has developed a comprehensive training plan that will prepare her with the requisite skill set for a research career in clarifying neurobiological mechanisms of eating disorders. The applicant’s F32 training and career development goals are to cultivate skills in interpretation of neuroendocrine and neuroimaging data to enhance knowledge of eating disorder pathophysiology and provide a strong foundation for submission of a K23 application. The data available to the applicant provide a unique opportunity to undertake a cross-disciplinary approach to compare reward processing between two major eating disorders. The proposed research may empirically differentiate low-weight eating disorders and reveal distinct neurobiological substrates for self- starvation. Further, the corresponding training plan will provide the applicant with the statistical, conceptual, and methodological foundation necessary to advance her research program and career.

项目总结/摘要 在这个博士后F32 Kirschstein NRSA，肯德拉贝克尔提出了一个全面的跨学科 研究和训练计划集中在两个不同的喂养和进食的基础上的异常奖励处理 以限制性进食为特征的疾病：神经性厌食症（AN）和回避/限制性食物摄入 疾病（ARFID）。低体重饮食失调与大量的医疗发病率，精神 并发症，死亡率增加和治疗费用高。肯德拉的长期研究计划目标是 通过多个分析单元检查饮食失调的情感维持机制， 目的是了解奖励和强化对饮食行为的影响，以告知小说 有针对性的干预措施。AN的初步研究结果表明，奖励处理的中断可能涉及 对低热量食物的偏好。对ARFID不存在此类调查。肯德拉建议将奖励 处理低热量和高热量食物图像之间的AN，ARFID，和控制在三个单位， 分析：神经影像学、激素水平和行为/自我报告测量。这一创新建议 通过利用目前资助的R 01（MH 103402）的数据来检查新的假设， 饮食病理学，视觉食物刺激的大脑激活，食欲调节激素水平。在 与她的共同赞助人Eddy，托马斯和Lawson博士以及专家顾问合作，申请人已经 我制定了一个全面的培训计划，这将为她的研究生涯提供必要的技能 阐明饮食失调的神经生物学机制。申请人的F32培训和职业 发展目标是培养解释神经内分泌和神经影像学数据的技能， 进食障碍病理生理学的知识，并为提交K23提供坚实的基础 应用程序.申请人可用的数据提供了一个独特的机会，进行跨学科的研究。 方法比较奖励处理两个主要的饮食失调。拟议的研究可能 经验区分低体重饮食失调，并揭示不同的神经生物学基板，为自我， 饥饿此外，相应的培训计划将为申请人提供统计，概念， 和必要的方法论基础，以推进她的研究计划和职业生涯。