Reward Processing in Anorexia Nervosa and Avoidant/Restrictive Food Intake: Behavior, DisorderHormonal Concentrations, and Brain Activation in Low-Weight Eating Disorders.

项目摘要/摘要 在这个博士后F32 Kirschstein NRSA中，Kendra Becker提出了一个全面的跨学科 研究和培训计划集中在两种不同的进食和进食背后的异常奖赏加工 以限制进食为特征的疾病：神经性厌食症(AN)和回避性/限制性食物摄入 精神障碍(ARFID)。低体重饮食障碍与大量的医学发病率、精神病学 合并症、死亡率增加和高昂的治疗费用。肯德拉的长期研究计划目标是 在多个分析单元中检查进食紊乱的情感维持机制 目的了解奖励和强化对进食行为的影响，以便为小说提供信息 有针对性的干预。一项研究的初步发现表明，奖励处理的中断可能涉及 喜欢低卡路里的食物。对于ARFID，没有这样的调查。肯德拉提议将报酬与 在AN、ARFID和对照之间处理三个单位的低卡路里和高卡路里食物图像 分析：神经成像、激素水平和行为/自我报告测量。这项创新的建议 通过利用来自当前资助的R01(MH103402)的数据来检查新的假设，具有测量 饮食病理，大脑对视觉食物刺激的激活，以及食欲调节激素的水平。在……里面 与她的共同赞助人Eddy，Thomas和Lawson博士以及专家顾问合作，申请者拥有 制定了一项全面的培训计划，为她的研究生涯准备必要的技能 在阐明进食障碍的神经生物学机制方面。申请人的F32培训和职业生涯 发展目标是培养解释神经内分泌和神经成像数据的技能，以增强 了解进食障碍的病理生理学，并为提交K23奠定坚实的基础 申请。申请人可获得的数据为开展跨学科研究提供了独特的机会。 比较两种主要饮食失调之间的奖励处理的方法。拟议的研究可能 经验性地区分低体重饮食障碍，并揭示自我 饿死了。此外，相应的培训计划将为申请者提供统计、概念、 以及推进她的研究计划和事业所需的方法学基础。

PROJECT SUMMARY/ABSTRACT In this postdoctoral F32 Kirschstein NRSA, Kendra Becker proposes a comprehensive interdisciplinary research and training plan focused on aberrant reward processing underlying two distinct feeding and eating disorders characterized by restrictive eating: anorexia nervosa (AN) and avoidant/restrictive food intake disorder (ARFID). Low-weight eating disorders are associated with substantial medical morbidity, psychiatric comorbidity, increased mortality, and high treatment costs. Kendra’s long-term research program goal is to examine affective maintaining mechanisms of disordered eating across multiple units of analysis for the purpose of understanding reward and reinforcement influences on eating behaviors in order to inform novel targeted interventions. Preliminary findings in AN suggest that disruptions in reward processing may involve preferences for low-calorie foods. No such investigations exist for ARFID. Kendra proposes to compare reward processing of low- and high- calorie food images between AN, ARFID, and controls across three units of analysis: neuroimaging, hormone levels, and behavioral/self-report measures. This innovative proposal examines novel hypotheses by leveraging data from a currently funded R01 (MH103402), featuring measures of eating pathology, brain activation to visual food stimuli, and levels of appetite regulating hormones. In collaboration with her co-sponsors, Drs. Eddy, Thomas, and Lawson, and expert consultants, the applicant has developed a comprehensive training plan that will prepare her with the requisite skill set for a research career in clarifying neurobiological mechanisms of eating disorders. The applicant’s F32 training and career development goals are to cultivate skills in interpretation of neuroendocrine and neuroimaging data to enhance knowledge of eating disorder pathophysiology and provide a strong foundation for submission of a K23 application. The data available to the applicant provide a unique opportunity to undertake a cross-disciplinary approach to compare reward processing between two major eating disorders. The proposed research may empirically differentiate low-weight eating disorders and reveal distinct neurobiological substrates for self- starvation. Further, the corresponding training plan will provide the applicant with the statistical, conceptual, and methodological foundation necessary to advance her research program and career.