Q-TB: Rapid, cheap POC diagnostic and drug susceptibility testing for human tuberculosis

Q-TB：快速、廉价的人类结核病 POC 诊断和药物敏感性测试

• 批准号: 101554
• 金额: $ 117.64万
• 依托单位: QUANTUMDX GROUP LIMITED
• 依托单位国家: 英国
• 项目类别: Collaborative R&D
• 财政年份: 2013
• 资助国家: 英国
• 起止时间: 2013 至 无数据
• 项目状态: 已结题
• 来源: https://gtr.ukri.org/projects?ref=101554
• 关键词: TB; Rapid; cheap; POC; diagnostic

The Q-TB project addresses some fundermental issues in the fight against tuberculosis. Firstly (SPEED & QUALITY) the project will deliver a technology that will enable patients to receive referral standard molecular diagnostic results within minutes, as they wait with their treating physician. Secondly (PORTABLE), if the patient is in a rural loctation, such as a township in South Africa, or in a mountain location in Peru, or in a remote part of Asia with no electricity, laboratory, clinic, or hospital nearnby, the size of the device (approximately the size of a 80's 'brick' mobile phone) and battery operation will enable even a technican or health worker (EASE OF USE) to perform a complex diagnosis. Thirdly (DRUG RESISTANCE), the device can test for many different things at once and this project will develop tests for both diagnosis of tuberculosis and test which drugs will work best to treat the disease. This complex testing system benefits from QuantuMDx's novel and hi-tech nanotechnologies that can perform complex tests in 10-15 minutes, when normally they hours to days, the expertise of Microsens in processing complex samples such as sputum, and the in depth tuberculosis knowlegde and testing experience of St Georges' Hospital, London, WHO TB group at Stellenbosch Univeristy, South Africa and several charities and NGOs throughout the world.

Q-TB 项目解决了抗击结核病的一些基本问题。首先（速度和质量）该项目将提供一种技术，使患者在等待治疗医生的过程中在几分钟内获得转诊标准分子诊断结果。其次（便携式），如果患者位于农村地区，例如南非的乡镇、秘鲁的山区或亚洲的偏远地区，附近没有电力、实验室、诊所或医院，设备的大小（大约是 80 年代“砖头”手机的大小）和电池操作甚至可以让技术人员或卫生工作者（易于使用）执行复杂的诊断。第三（耐药性），该设备可以同时测试许多不同的东西，该项目将开发用于诊断结核病的测试，并测试哪些药物最适合治疗该疾病。这种复杂的测试系统受益于 QuantuMDx 的新颖高科技纳米技术，可以在 10-15 分钟内完成复杂的测试（通常需要数小时到数天），Microsens 在处理痰等复杂样本方面的专业知识，以及伦敦圣乔治医院、南非斯泰伦博斯大学 WHO 结核病小组和多个慈善机构的深入结核病知识和测试经验。 世界各地的非政府组织。