iGLAMOUR Study: Innovations in Glaucoma Adherence and monitoring Of Under-Represented minorities
iGLAMOUR 研究:青光眼依从性和监测代表性不足的少数群体的创新
基本信息
- 批准号:10549804
- 负责人:
- 金额:$ 52.96万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2021
- 资助国家:美国
- 起止时间:2021-01-15 至 2024-12-31
- 项目状态:已结题
- 来源:
- 关键词:AdherenceAffectAfrican AmericanAfrican American populationAlgorithmsArtificial IntelligenceBlindnessBluetoothCaucasiansChronic DiseaseClinicalClinical TrialsComplexCounselingDataDevelopmentDiagnosisDisease ProgressionEarly InterventionEarly identificationEffectivenessElectronic Health RecordElectronicsEvaluationEyeEye diseasesEyedropsGlaucomaHealthHealth Care CostsHealth TechnologyIndividualInterventionIntervention StudiesInterviewKnowledgeLabelLatinoLatino PopulationLifeMachine LearningMeasuresMedication ManagementMethodsMinorityMinority GroupsModelingMonitorOptical Coherence TomographyOutcomePatient Self-ReportPatientsPatternPerformancePersonsPharmaceutical PreparationsPhysiciansPhysiologic Intraocular PressurePopulationPrevalenceProcessProliferatingProviderQualitative EvaluationsQuality of lifeRecommendationReportingResearchRisk ReductionScreening procedureSignal TransductionStructureTechnologyTestingThickTopical applicationUnderrepresented MinorityVariantVisionVisual Fieldsadherence rateblindcentralized portalclinical decision-makingclinical riskdashboarddata visualizationdesigndigitaldosageeffective interventionelectronic sensorexperiencefield studyflexibilityflexible electronicsglaucoma testhealth care deliveryhealth information technologyhigh riskhuman centered designimprovedinnovationinterestinteroperabilitymHealthmachine learning modelmachine learning predictionmedication compliancemedication nonadherencemobile applicationmobile computingparticipant interviewpatient engagementpersonalized carepredictive modelingprimary outcomeprototyperacial disparityracial health disparityretinal nerve fiber layerrisk predictionrisk stratificationsecondary outcomesensorsensor technologysocial culturesocial health determinantssuccesssupport toolstherapeutic targettransmission processusabilitywireless
项目摘要
PROJECT SUMMARY/ABSTRACT
Glaucoma affects more than 70 million people worldwide and is the world's leading cause of irreversible
blindness. The only current method to delay its development and progression is by lowering intraocular
pressure (IOP), achieved with topical administration of eyedrops. Adherence rates for glaucoma eyedrop
administration are poor, in many cases below 50%, resulting in disease progression, eventual blindness, and a
more than 2-fold increase in healthcare costs.
African Americans and Latinos carry a significantly higher glaucoma burden compared with Caucasians.
Minorities have additionally been found to have disproportionately lower rates of medication adherence.
Previously studied interventions aimed at improving glaucoma adherence had key limitations that particularly
affect minorities, including unreliable self-reported measures of adherence, lack of consideration of individual
circumstances influencing glaucoma medication management, and developing/testing interventions in
predominantly Caucasian populations.
Health information technology has experienced rapid advancement in the last decade with the electronic health
record (EHR), the proliferation of accessory mobile health technologies, and the advancement of artificial
intelligence. Although their integration holds great promise to enable screening tools for diagnosis and risk
prediction, successful integration to aid minority populations in real-world settings depends on: understanding
how the collected information relates to the patient's other (e.g. clinical) data and the patient's socio-cultural
context; seamless information exchange and interoperability with the EHR, the central portal of healthcare
delivery; and integration of algorithmic findings into workflows involving both providers and patients to deliver
information and/or recommendations in a simple, actionable manner.
Glaucoma is a complex chronic disease, spanning decades of patients' lives and requiring ongoing monitoring
and evaluation, thus making it an ideal application for the use of health IT to reduce racial disparities. In this
proposal, we aim to accomplish this by: demonstrating the effectiveness of a flexible electronic eyedrop sensor
to generate granular digital signatures of an individual's adherence and contextualizing this data in a socio-
cultural context with patient interviews (Aim 1), combining adherence data with EHR variables to construct
machine learning models to predict IOP control and enhance clinical risk stratification (Aim 2), and prototyping
a dynamic dashboard for intervention coordination (Aim 3). Altogether, success of this innovative,
comprehensive, culturally-tailored, and scalable health IT framework will improve medication adherence and
slow disease progression among minorities, therefore narrowing this important racial health disparity.
项目概要/摘要
青光眼影响着全球超过 7000 万人,是世界上不可逆转的首要原因
失明。目前唯一延缓其发生和进展的方法是降低眼内压
眼压(IOP),通过局部滴眼药水来实现。青光眼滴眼液的依从率
管理不善,在许多情况下低于 50%,导致疾病进展,最终失明,并导致
医疗费用增加超过2倍。
与白种人相比,非裔美国人和拉丁裔的青光眼负担明显更高。
此外还发现少数族裔的药物依从率特别低。
先前研究的旨在改善青光眼依从性的干预措施存在关键局限性,特别是
影响少数群体,包括自我报告的遵守措施不可靠、缺乏对个人的考虑
影响青光眼药物管理的情况,以及开发/测试干预措施
主要是白种人群体。
随着电子医疗的发展,医疗信息技术在过去十年中经历了快速发展
记录(EHR)、辅助移动医疗技术的普及以及人工技术的进步
智力。尽管它们的集成有望实现诊断和风险筛查工具
预测,在现实世界环境中成功融入援助少数民族人口取决于: 理解
收集到的信息如何与患者的其他(例如临床)数据和患者的社会文化相关
语境;与医疗保健中央门户 EHR 的无缝信息交换和互操作性
送货;并将算法结果整合到涉及提供者和患者的工作流程中以交付
以简单、可操作的方式提供信息和/或建议。
青光眼是一种复杂的慢性疾病,影响患者数十年的生命,需要持续监测
和评估,从而使其成为利用卫生信息技术减少种族差异的理想应用。在这个
建议,我们的目标是通过以下方式实现这一目标: 展示柔性电子滴眼剂传感器的有效性
生成个人依从性的精细数字签名,并将这些数据置于社会背景中
文化背景与患者访谈(目标 1),将依从性数据与 EHR 变量相结合来构建
用于预测 IOP 控制并增强临床风险分层(目标 2)的机器学习模型和原型设计
用于协调干预的动态仪表板(目标 3)。总而言之,这一创新的成功,
全面、根据文化定制且可扩展的健康 IT 框架将提高用药依从性和
减缓少数族裔疾病的进展,从而缩小这一重要的种族健康差距。
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
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Todd P Coleman其他文献
Assessing time-varying causality network of ensemble neural spiking activity
- DOI:
10.1186/1471-2202-12-s1-p43 - 发表时间:
2011-07-18 - 期刊:
- 影响因子:2.300
- 作者:
Sanggyun Kim;Marcelo Aguilar;Todd P Coleman - 通讯作者:
Todd P Coleman
A Markov chain model of the evolution of complex neuronal network structures in the presence of plasticity
- DOI:
10.1186/1471-2202-11-s1-p61 - 发表时间:
2010-07-20 - 期刊:
- 影响因子:2.300
- 作者:
Nana Arizumi;Todd P Coleman;R Lee DeVille - 通讯作者:
R Lee DeVille
Todd P Coleman的其他文献
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{{ truncateString('Todd P Coleman', 18)}}的其他基金
Traveling waves in neocortical circuits: Mechanisms, computational roles in sensory processing, and impact on sensory perception
新皮质回路中的行波:感觉处理中的机制、计算作用以及对感觉知觉的影响
- 批准号:
10655101 - 财政年份:2023
- 资助金额:
$ 52.96万 - 项目类别:
Inverse Methods for Spatiotemporal Characterization of Gastric Electrical Activity and its Association with Upper GI Symptoms from Cutaneous Multi-electrode Recordings
皮肤多电极记录胃电活动时空特征及其与上消化道症状关联的逆向方法
- 批准号:
10196836 - 财政年份:2021
- 资助金额:
$ 52.96万 - 项目类别:
iGLAMOUR Study: Innovations in Glaucoma Adherence and monitoring Of Under-Represented minorities
iGLAMOUR 研究:青光眼依从性和监测代表性不足的少数群体的创新
- 批准号:
10330002 - 财政年份:2021
- 资助金额:
$ 52.96万 - 项目类别:
Inverse Methods for Spatiotemporal Characterization of Gastric Electrical Activity and its Association with Upper GI Symptoms from Cutaneous Multi-electrode Recordings
皮肤多电极记录胃电活动时空特征及其与上消化道症状关联的逆向方法
- 批准号:
10394942 - 财政年份:2021
- 资助金额:
$ 52.96万 - 项目类别:
A Novel Model System for Restoring Hearing in vivo
一种恢复体内听力的新型模型系统
- 批准号:
10224166 - 财政年份:2020
- 资助金额:
$ 52.96万 - 项目类别:
A Novel Model System for Restoring Hearing in vivo
一种恢复体内听力的新型模型系统
- 批准号:
10058225 - 财政年份:2020
- 资助金额:
$ 52.96万 - 项目类别:
SCH: Interface Monitoring System to Promote Residual Limb Health
SCH:促进残肢健康的接口监控系统
- 批准号:
8930987 - 财政年份:2014
- 资助金额:
$ 52.96万 - 项目类别:
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