ENDS use trajectories from adolescence through young adulthood: A longitudinal study of risk factors and profiles

ENDS 从青春期到成年早期的使用轨迹：风险因素和概况的纵向研究

• 批准号: 10551312
• 负责人: Melissa Blythe Harrell
• 金额: $ 59.47万
• 依托单位: UNIVERSITY OF TEXAS HLTH SCI CTR HOUSTON
• 依托单位国家: 美国
• 财政年份: 2019
• 资助国家: 美国
• 起止时间: 2019-02-15 至 2025-01-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10551312
• 关键词: 15 year old; 17 year old; Acceleration; Adolescence; Adolescent; Adolescent and Young Adult; Age; Age Years; Area; Behavior; Behavioral; Cigarette; Data; Data Collection; Demographic Factors; Development; Electronic Nicotine Delivery Systems; Environmental Risk Factor; Escalator; Esthesia; Ethnic Origin; Exhibits; Female; Friends; Growth; Health; Heterogeneity; High Prevalence; High School Student; Hispanic Populations; Life; Life Cycle Stages; Link; Longitudinal Studies; Marketing; Measures; Methodology; Methods; Modeling; Natural History; Nicotine Dependence; Not Hispanic or Latino; Online Systems; Outcome; Pattern; Perception; Persons; Play; Post Graduate Year; Predisposition; Race; Reporting; Research; Risk; Risk Factors; Role; Sales; Sampling; Students; Subgroup; Surveys; Testing; Texas; Time; Tobacco; Tobacco use; age group; austin; cigarette smoking; cohort; combustible tobacco; design; early adolescence; effective intervention; eighth grade; follow-up; high risk; high school; implementation intervention; innovation; junior high school; male; marijuana use; metropolitan; peer; population based; preventive intervention; sex; sixth grade; tenth grade; tobacco products; underage drinking; uptake; young adult

ABSTRACT The primary objective of this study is to identify, describe, and differentiate stable and persistent patterns in trajectories of ENDS use, from 11 to 22 years of age. Seventy percent of adolescent never users will be susceptible to ENDS and other tobacco use by the age of 17 – and, by age 22, in young adulthood, the same proportion will have ever used ENDS or tobacco. Understanding what accelerates this rapid progression in tobacco use behaviors and related outcomes from them (e.g., nicotine dependence) will help inform the development of effective interventions. Considerable controversy exists regarding the role that electronic nicotine delivery systems (ENDS) play in the uptake, progression, and/or cessation of combustible tobacco product use, and appropriate ways to measure and model this. To date, almost all studies of ENDS use behaviors are either cross-sectional or limited to short-term (e.g., 1 year) follow-up, which is inadequate for identifying sustained patterns in ENDS use trajectories across the life course, given that transitions in tobacco use behaviors (i.e., initiation to sustained use or quitting) and between tobacco products (e.g., ENDS and cigarettes) are frequent and erratic. Longer-term studies of patterns in ENDS use trajectories are critical, but they will require additional data collection efforts; especially, regionally. Using a cohort-sequential design, we propose to follow and connect 3 existing, population-based cohorts of adolescents (11-15 years old at Wave 1, 2014-15) through young adulthood (18-22 years old at Wave 14, 2021), to represent developmental changes in ENDS use behaviors across these critical stages in the life course. At Wave 1, during the 2014-15 academic year, the sample included 3,907 (N=461,069) students in the 6th, 8th, and 10th grades in 79 middle schools and high schools (N=1969) in the 4 largest metropolitan areas of Texas: Houston, Dallas/Ft. Worth, San Antonio, and Austin. At Wave 8 (June, 2018), retention remained high, at 85%; the oldest cohort is now 1 year post high school. We propose to follow these cohorts for an additional 6 waves of data collection, every 6 months, to track them all through high school (1, 3, and 5 years post-graduation), into young adulthood. Our web-based surveys include robust measures of ENDS use and other tobacco use behaviors; nicotine dependence; and a broad spectrum of potential risk factors, including intrapersonal, interpersonal, and environmental influences. Growth mixture models shall be applied to these data to empirically identify stable developmental patterns in ENDS use behaviors, from 11 to 22 years of age; we anticipate there will be substantial heterogeneity in them. We will be able to identify young adult outcomes of persistent patterns in ENDS use that begin in adolescence; and risk factors in adolescence that predict ENDS use trajectories that persist into young adulthood. The use of combustible tobacco products in adolescence and young adulthood will be considered, accordingly. Almost all (>95% of) existing cohorts and studies of ENDS use focus on either adolescents or young adults. Very few, like ours, are able to track adolescents into young adulthood to investigate developmental trajectories of risk.

摘要 这项研究的主要目标是识别、描述和区分稳定和持续的模式 使用末端的轨迹，从11岁到22岁。70%的青少年从不使用 17岁时易受烟头和其他烟草的影响--22岁时也是如此 有比例的人将曾经使用过烟头或烟草。了解是什么加速了这一快速发展 烟草使用行为及其相关结果(例如尼古丁依赖)将有助于了解 制定有效的干预措施。关于电子产品的作用存在相当大的争议 尼古丁递送系统(END)在可燃烟草的吸收、进展和/或停止中发挥作用 产品使用，以及测量和建模的适当方法。到目前为止，几乎所有关于END的研究都使用 行为要么是跨部门的，要么限于短期(例如1年)随访，这不足以 考虑到烟草的转变，识别末端的持续模式使用整个生命过程的轨迹 使用行为(即开始持续使用或戒烟)以及烟草产品之间的使用行为(例如，结束和戒烟 香烟)频繁且反复无常。对终端使用轨迹的长期研究是至关重要的，但 它们将需要更多的数据收集工作；特别是在区域范围内。使用队列序贯设计，我们 建议跟踪和连接3个现有的以人口为基础的青少年队列(11-15岁的第一波， 2014-15年)到成年(2021年第14波，18-22岁)，代表着 Ends使用生命过程中这些关键阶段的行为。在2014-15年度的第一波学术 年，样本包括79所中学6年级、8年级和10年级的3907名学生(N=461,069)。 德克萨斯州四个最大的大都会地区的高中(N=1969)：休斯顿、达拉斯/堡垒。沃斯，圣安东尼奥， 还有奥斯汀。在第8波(2018年6月)，保留率仍然很高，为85%；最年长的队列现在是一年后的高点 学校。我们建议跟随这些队列，每6个月额外收集6波数据，以 从高中(毕业后1年、3年和5年)一直跟踪他们，直到他们成年。我们基于网络的 调查包括对终端使用和其他烟草使用行为的强有力的衡量；尼古丁依赖；以及 广泛的潜在风险因素，包括个人内部、人际关系和环境影响。 应将增长混合模型应用于这些数据，以经验地确定稳定的发展模式 终端使用行为，从11岁到22岁；我们预计他们将会有很大的异质性。 我们将能够确定从青春期开始的终端持续使用模式对年轻人的影响； 而预测青春期结束的风险因素使用的轨迹一直持续到年轻成年。对.的使用 因此，青春期和青春期的可燃烟草产品将被考虑在内。几乎所有的 (95%)现有的队列和对END使用的研究集中在青少年或年轻人身上。很少， 像我们一样，能够跟踪青少年到青壮年，以调查风险的发育轨迹。

项目成果

Comparing Risk Factors for Past 30-day E-cigarette and Combustible Tobacco Use: A Longitudinal Analysis of the Texas Adolescent Tobacco and Marketing Surveillance Study (2014-2017).

比较过去 30 天电子烟和可燃烟草使用的风险因素：德克萨斯州青少年烟草和营销监测研究的纵向分析（2014-2017 年）。

• 发表时间: 2021
• 期刊: Texas public health journal
• 作者: Obinwa,Udoka;Clendennen,StephanieL;Rangwalam,Shazia;Sumbe,Aslesha;Case,KathleenR;Harrell,MelissaB
• 通讯作者: Harrell,MelissaB

Risk of respiratory, gastrointestinal, and constitutional health symptoms: A cross-sectional study of Texas adolescent and young adult nicotine and marijuana vapers.

• DOI: 10.1016/j.ypmed.2022.107057
• 发表时间: 2022-06
• 期刊: PREVENTIVE MEDICINE
• 影响因子: 5.1
• 作者: Case, Kathleen R.;Clendennen, Stephanie L.;Tsevat, Joel;Harrell, Melissa B.
• 通讯作者: Harrell, Melissa B.

Changes in marijuana and nicotine vaping perceptions and use behaviors among young adults since the COVID-19 pandemic: A qualitative study.

• DOI: 10.1016/j.abrep.2022.100408
• 发表时间: 2022-06
• 期刊: Addictive behaviors reports
• 作者: Case KR;Clendennen SL;Shah J;Tsevat J;Harrell MB
• 通讯作者: Harrell MB

Stress, Dependence, and COVID-19-related Changes in Past 30-day Marijuana, Electronic Cigarette, and Cigarette Use among Youth and Young Adults.

• DOI: 10.1177/1179173x211067439
• 发表时间: 2021
• 期刊: Tobacco use insights
• 影响因子: 2.2
• 作者: Clendennen SL;Case KR;Sumbe A;Mantey DS;Mason EJ;Harrell MB
• 通讯作者: Harrell MB

Association of tobacco and marijuana use with symptoms of depression and anxiety among adolescents and young adults in Texas.

• DOI: 10.18332/tpc/144500
• 发表时间: 2022
• 期刊: Tobacco prevention & cessation
• 影响因子: 1.8
• 作者: Sumbe A;Wilkinson AV;Clendennen SL;Bataineh BS;Sterling KL;Chen B;Harrell MB
• 通讯作者: Harrell MB