Optimizing interventions to mitigate schistosomiasis-related morbidity among pregnant women and children

项目摘要 这份K24续签申请旨在继续为候选人詹妮弗·弗里德曼提供时间， 医学博士，为初级教员提供以患者为中心的研究(POR)的指导，重点是优化 孕妇和儿童寄生虫病干预措施。第二个目标是提供时间 对于弗里德曼博士来说，通过)追求结构方面的高级教育来促进她自己的职业发展 人类微生物群的方程建模和表征以及b)引导政策变化，包括 参加血吸虫病治疗方案的孕妇和幼儿。 弗里德曼博士建议继续指导初级教职员工和研究员在该中心进行POR 国际卫生研究(CIHR)。该中心是跨学科团队科学的杰出典范， 在大多数教员都是内科医生的地方，科学家和其他科学家将翻译研究作为一个整体进行 这些团队中的一员。在K24课程的第一阶段，弗里德曼博士密切指导了CIHR的五名初级教员。的 其中四人获得了职业发展奖，弗里德曼博士担任主要或联合导师， 另一位是一名目标年轻研究员，获得了一笔大笔培训补助金(生物医学研究卓越中心 (科布雷))在传染病方面。此外，有一名被辅导者(莱文)获得了他的第一笔独立赠款(R03 和R01)在弗里德曼博士提供的赠款撰写指导下于2017年。 这项提议的首要科学目标是通过以下途径推进阐明机制的研究 哪种血吸虫病会导致环境肠病，最终导致微生物易位， 系统免疫激活、不良妊娠和营养结局。弗里德曼博士有两个电流 R01为初级教师提供了在全球卫生领域开展POR的绝佳机会。第一个是一个 纵向出生队列(Pis Friedman，Gundogan)，已经招募了N=400名孕妇， 现在跟踪新生儿直到两岁。第二项是多点随机对照试验(Pis Friedman，Bustduy)检查 四岁以下儿童使用吡喹酮的最佳剂量和给药频率。这两项赠款都提供了 有机会与长期合作的地点进行现场工作，并将提供丰富的油井 特性化的数据和样本，以满足本K24中提出的目标以及设想的其他目标 被辅导者。他们还将能够在弗里德曼博士的共同指导下，参与CIHR的其他NIH赠款 和其他教职员工(见支持信)。 布朗大学附属医院为来自不同部门的潜在学员提供了丰富的来源 有兴趣在传染病方面进行POR的初级教员。此外，尽管有 布朗附属公司的许多其他培训赠款，有两个T32奖，两个科布尔奖，一个 R25，它可以专门为年轻研究人员提供渠道，并在以下研究领域提供共同资金 弗里德曼博士对此感兴趣。

Project Summary This renewal application for a K24 seeks to continue to provide time for the candidate, Jennifer Friedman, MD, PhD, to provide mentorship to junior faculty in patient oriented research (POR) with a focus on optimizing interventions for parasitic diseases among pregnant women and children. The second goal is to provide time for Dr. Friedman to further her own career development through a) pursuit of advanced education in Structural Equation Modeling and characterization of the human microbiome and b) leading policy changes to include pregnant women and young children in treatment programs for schistosomiasis. Dr. Friedman proposes to continue to mentor junior faculty and fellows conducting POR at the Center for International Health Research (CIHR). The Center is an outstanding model for interdisciplinary team science, where most faculty are physician-scientists and other scientists carry out translational research as an integral part of these teams. In the first phase of this K24, Dr. Friedman closely mentored five junior faculty at CIHR. Of these, four were recipients of Career Development Awards with Dr. Friedman as primary or co-mentor and the other was a target young investigator on a large training grant (Centers for Biomedical Research Excellence (COBRE)) in infectious diseases. In addition, one mentee (Levine) received his first independent grants (R03 and R01) in 2017 with grant writing mentorship provided by Dr. Friedman. The overarching scientific goal of this proposal is to advance studies elucidating mechanisms through which schistosomiasis contributes to environmental enteropathy, culminating in microbial translocation, systemic immune activation, and adverse pregnancy and nutritional outcomes. Dr. Friedman has two current R01s that provide outstanding opportunities for junior faculty to conduct POR in global health. The first is a longitudinal birth cohort (PIs Friedman, Gundogan) that has already enrolled N=400 pregnant women and is now following the newborns until age two. The second is a multi-site RCT (PIs Friedman, Bustinduy) examining optimal dose and dosing frequency of praziquantel for children under the age of four. Both grants provide both opportunities to conduct field work at sites with longstanding collaborations and will offer a wealth of well characterized data and samples to address the aims proposed in this K24 as well as other aims conceived of by mentees. They will also be able to engage in other NIH grants at CIHR with co-mentoring by Dr. Friedman and other faculty (see letters of support). Brown University affiliated hospitals provide a rich source of potential mentees from a range of Divisions housing junior faculty interested in conducting POR in infectious diseases. In addition, although there are numerous other training grants at Brown affiliates, there are two T32 awards, two COBRE awards, and one R25, which could specifically provide a pipeline for young investigators and co-funding in research areas of interest to Dr. Friedman.