Optimizing interventions to mitigate schistosomiasis-related morbidity among pregnant women and children

项目摘要 K24的延期申请旨在继续为候选人詹妮弗·弗里德曼提供时间， 医学博士，博士，为初级教师提供指导，以患者为导向的研究（POR），重点是优化 对孕妇和儿童的寄生虫病采取干预措施。第二个目标是提供时间 弗里德曼博士通过a）追求结构方面的高等教育来促进自己的职业发展 人类微生物组的方程建模和表征，以及B）导致政策变化，包括 孕妇和幼儿参加血吸虫病治疗方案。 弗里德曼博士建议继续指导初级教师和研究员进行POR在该中心， 国际卫生研究所。该中心是跨学科团队科学的杰出典范， 在那里，大多数教师都是医学科学家，其他科学家将转化研究作为一个整体来进行。 这些团队的一部分。在K24的第一阶段，弗里德曼博士密切指导了CIHR的五名初级教师。的 其中，四人获得了职业发展奖，弗里德曼博士是主要或共同导师， 另一个是一个目标的年轻研究人员在一个大的培训补助金（中心生物医学研究卓越 （COBRE））在传染病中的作用。此外，一名学员（Levine）获得了第一笔独立赠款（R03 和R01）在2017年与弗里德曼博士提供的赠款写作指导。 该提案的总体科学目标是通过以下方式推进阐明机制的研究 血吸虫病导致环境性肠病，最终导致微生物移位， 全身免疫激活和不良妊娠和营养结果。弗里德曼博士目前有两个 R 01为初级教师提供了在全球卫生领域进行POR的绝佳机会。第一个是 纵向出生队列（PI Friedman，Gundogan），已经招募了N=400名孕妇， 现在跟踪新生儿直到两岁。第二个是多中心随机对照试验（PI Friedman，Bustinduy）， 吡喹酮对4岁以下儿童的最佳剂量和给药频率。这两项赠款都提供 有机会在长期合作的地点进行实地工作，并将提供丰富的 特征化数据和样本，以实现本K24中提出的目标以及 被mentees。他们还将能够在CIHR与弗里德曼博士共同指导下参与其他NIH赠款 和其他教师（见支持信）。 布朗大学附属医院提供了来自一系列部门的潜在学员的丰富来源 有兴趣在传染病方面进行POR的初级教师的住房。此外，虽然有 在布朗附属公司的许多其他培训赠款，有两个T32奖，两个COBRE奖，和一个 R25可以专门为年轻的研究人员提供渠道，并在以下研究领域共同资助： 弗里德曼博士的兴趣。

Project Summary This renewal application for a K24 seeks to continue to provide time for the candidate, Jennifer Friedman, MD, PhD, to provide mentorship to junior faculty in patient oriented research (POR) with a focus on optimizing interventions for parasitic diseases among pregnant women and children. The second goal is to provide time for Dr. Friedman to further her own career development through a) pursuit of advanced education in Structural Equation Modeling and characterization of the human microbiome and b) leading policy changes to include pregnant women and young children in treatment programs for schistosomiasis. Dr. Friedman proposes to continue to mentor junior faculty and fellows conducting POR at the Center for International Health Research (CIHR). The Center is an outstanding model for interdisciplinary team science, where most faculty are physician-scientists and other scientists carry out translational research as an integral part of these teams. In the first phase of this K24, Dr. Friedman closely mentored five junior faculty at CIHR. Of these, four were recipients of Career Development Awards with Dr. Friedman as primary or co-mentor and the other was a target young investigator on a large training grant (Centers for Biomedical Research Excellence (COBRE)) in infectious diseases. In addition, one mentee (Levine) received his first independent grants (R03 and R01) in 2017 with grant writing mentorship provided by Dr. Friedman. The overarching scientific goal of this proposal is to advance studies elucidating mechanisms through which schistosomiasis contributes to environmental enteropathy, culminating in microbial translocation, systemic immune activation, and adverse pregnancy and nutritional outcomes. Dr. Friedman has two current R01s that provide outstanding opportunities for junior faculty to conduct POR in global health. The first is a longitudinal birth cohort (PIs Friedman, Gundogan) that has already enrolled N=400 pregnant women and is now following the newborns until age two. The second is a multi-site RCT (PIs Friedman, Bustinduy) examining optimal dose and dosing frequency of praziquantel for children under the age of four. Both grants provide both opportunities to conduct field work at sites with longstanding collaborations and will offer a wealth of well characterized data and samples to address the aims proposed in this K24 as well as other aims conceived of by mentees. They will also be able to engage in other NIH grants at CIHR with co-mentoring by Dr. Friedman and other faculty (see letters of support). Brown University affiliated hospitals provide a rich source of potential mentees from a range of Divisions housing junior faculty interested in conducting POR in infectious diseases. In addition, although there are numerous other training grants at Brown affiliates, there are two T32 awards, two COBRE awards, and one R25, which could specifically provide a pipeline for young investigators and co-funding in research areas of interest to Dr. Friedman.