Reducing Drug-Related Mortality Using Predictive Analytics: A Randomized, Statewide, Community Intervention Trial

使用预测分析降低药物相关死亡率：一项随机、全州范围的社区干预试验

• 批准号: 10554963
• 负责人: Magdalena Cerda
• 金额: $ 17.84万
• 依托单位: BROWN UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2019
• 资助国家: 美国
• 起止时间: 2019-09-30 至 2024-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10554963
• 关键词: Address; Admission activity; American; Area; Censuses; Cities; Classification; Client; Communities; Consumption; Country; Data; Decision Making; Disease; Disease Outbreaks; Dose; Drug usage; Emergency medical service; Environment; Epidemic; Evaluation; Event; Foundations; Future; Goals; Health; Health Policy; Health Priorities; Hospitals; Human Resources; Individual; Intervention; Intervention Community Trial; Intervention Trial; Machine Learning; Measures; Modeling; Naloxone; National Institute of Drug Abuse; Neighborhoods; New York City; Outcome; Overdose; Overdose reduction; Pharmaceutical Preparations; Policies; Population; Predictive Analytics; Prevention; Prevention program; Probability; Prospective cohort; Public Health; Publishing; Randomized; Recording of previous events; Records; Recovery; Research; Resource Allocation; Resources; Rhode Island; Risk; Services; Source; Sterility; Strategic Planning; Supervision; System; Testing; Time; Training; United States; Visit; addiction; base; behavioral health; care outcomes; education access; evidence base; experience; experimental study; high risk; improved; indexing; machine learning method; machine learning prediction algorithm; mortality; novel; opioid agonist therapy; opioid misuse; opioid mortality; opioid overdose; opioid policy; opioid use disorder; overdose death; overdose prevention; overdose risk; peer; population based; predictive modeling; prescription opioid; prevent; primary outcome; programs; recruit; referral services; response; spatiotemporal; surveillance data; tool; treatment arm; trend

PROJECT SUMMARY The drug overdose crisis has claimed more than one million lives in the United States over the past two decades. In response to this crisis, New York City has implemented the nation’s first publicly recognized overdose prevention centers (OPCs), which are facilities that permit clients to consume pre-obtained controlled substances under the supervision of personnel who are trained to intervene in the event of an overdose. Staff at OPCs also provide safer drug consumption education, access to sterile drug use supplies, offer other health and ancillary services, and provide referrals to other treatment, health, and recovery services. In July 2021, Rhode Island became the first state to authorize overdose prevention centers (OPCs), with plans to open in March 2022. While studies from other countries have demonstrated that OPCs have individual and community benefits, there exist no evaluations of sanctioned OPCs in the United States. The proposed research is of high public health and policy significance, since this project will, for the first time, determine the potential benefits and unintended consequences of sanctioned OPCs in the US. As a first step, we will evaluate immediate, post[1]OPC implementation changes in measures of drug-related public disorder (e.g., drug use in public, drug-related litter) and compare these changes to trends in control neighborhoods that do not contain OPCs (Aim 1). We will also establish the feasibility of recruiting and retaining a prospective cohort of clients who use an OPC in New York City and Rhode Island to examine a range of behavioral, health, and linkage to care outcomes (Aim 2). If successful, this preliminary research will lay the foundation for a robust, multi-component, longer-term study to evaluate the breadth of individual and community-level outcomes associated with OPC implementation in these two jurisdictions.

项目摘要 过去二十年来，药物过量危机已夺去了美国超过一百万人的生命。为了应对这场危机，纽约市建立了全国首个获得公众认可的药物过量预防中心 (OPC)，这些设施允许客户在接受过药物过量干预培训的人员的监督下服用预先获得的受控药物。 OPC 的工作人员还提供更安全的药物消费教育、获得无菌药物使用用品、提供其他健康和辅助服务，并提供其他治疗、健康和康复服务的转介。 2021 年 7 月，罗德岛州成为第一个授权过量预防中心 (OPC) 的州，并计划于 2022 年 3 月开业。虽然其他国家的研究表明 OPC 具有个人和社区效益，但美国尚未对批准的 OPC 进行评估。拟议的研究具有很高的公共卫生和政策意义，因为该项目将首次确定美国受制裁 OPC 的潜在益处和意外后果。第一步，我们将评估 OPC 实施后与毒品相关的公共秩序混乱（例如公共场所吸毒、与毒品相关的垃圾）措施的即时变化，并将这些变化与不含 OPC 的对照社区的趋势进行比较（目标 1）。我们还将建立招募和留住纽约市和罗德岛州使用 OPC 的潜在客户群体的可行性，以检查一系列行为、健康状况以及与护理结果的联系（目标 2）。如果成功，这项初步研究将为一项强有力的、多组成部分的长期研究奠定基础，以评估这两个司法管辖区与 OPC 实施相关的个人和社区层面成果的广度。