Advancing Microstructural and Vascular Neuroimaging in Perinatal Stroke
推进围产期卒中的微观结构和血管神经影像学
基本信息
- 批准号:10552663
- 负责人:
- 金额:$ 34.85万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2019
- 资助国家:美国
- 起止时间:2019-02-15 至 2025-01-31
- 项目状态:未结题
- 来源:
- 关键词:AcuteAddressAdultAnticoagulant therapyBlood VesselsBrainBrain InjuriesBrain Vascular MalformationCephalicCerebral PalsyCerebrovascular CirculationChildClassificationClinicClinicalClinical TrialsCoagulation ProcessComplexDataDevelopmentDevelopmental Therapeutics ProgramDiagnosisDiffusionDiffusion Magnetic Resonance ImagingEarly DiagnosisEdemaEducationEnvironmentEpilepsyEvaluationEventExposure toFascicleFetusFiberGrowthHead MovementsHemorrhageHigh PrevalenceHumanImageImaging TechniquesImaging technologyImmobilizationImpairmentInfantInflammationInjuryIonizing radiationKnowledgeLifeLinkMRI ScansMagnetic Resonance AngiographyMagnetic Resonance ImagingMapsMedical ImagingMethodsMissionModelingMorphologic artifactsMotionNerve DegenerationNeurological outcomeNewborn InfantNoiseOutcomePatientsPhlebographyPredispositionPrognosisPropertyProtocols documentationPublic HealthResearchResolutionSamplingSedation procedureSignal TransductionSiteSourceStrokeStructureTechniquesTechnologyTherapeuticTherapeutic InterventionThrombusUltrasonographyUnited States National Institutes of HealthVeinsX-Ray Computed Tomographyaccurate diagnosisblood productbrain abnormalitiesbrain tissuecerebrovascularclinical imagingclinical prognosisdensitydisabilityfetalhigh resolution imagingimage processingimage reconstructionimprovedin vivoin vivo evaluationinnovationischemic lesionmyelinationnatural hypothermianeonatenervous system disorderneuralneuroimagingneuroprotectionneurovascularperinatal brainperinatal strokepost strokepostnatalpreventive interventionprospectiveresearch clinical testingresearch studyresponsespatiotemporalstem cell therapytherapeutic targettoolvasogenic edema
项目摘要
Advancing microstructural and vascular neuroimaging in perinatal stroke
The overall objective of this research is to dramatically improve early diagnosis and prognosis of perinatal
stroke to identify the best management options and therapeutic targets for patients with a poor prognosis.
Magnetic resonance imaging (MRI) is considered a safe and sensitive tool for the diagnosis and evaluation of
perinatal stroke and the response of the rapidly growing young brain to this injury. Advanced MRI techniques,
in particular, diffusion-compartment imaging (DCI), susceptibility-weighted MRI (SWI), and magnetic resonance
angiography (MRA) are considered crucial components of a clinical imaging protocol to evaluate stroke and
brain injury. The application of these techniques in the fetal period, however, is extremely challenging because
of the small signal available from the small fetal neural and vascular structures and the intermittent fetal and
maternal motion that disrupts the spatial encoding necessary for these typically lengthy MRI scans. Postnatal
MRI poses similar challenges, particularly with respect to small head movements, which produce significant
artifacts in longer acquisitions. Sedation, which is used to immobilize infants and very young children, is
invasive and potentially harmful; and thus, cannot be used in research studies. There is a critical need,
therefore, for motion-robust, high-resolution, advanced MRI technologies to evaluate neural and neurovascular
structures in the fetus and neonate. The lack of such imaging technology significantly limits clinical evaluation
and prognosis, as well as research on perinatal stroke. This project aims to fill these gaps in technology
through the development of innovative, motion-robust, high-resolution MRI sequences, specifically, DCI, SWI,
and MRA to evaluate neurovascular microstructure, cerebral vascular malformations, and brain network injury
after perinatal stroke. The three specific aims of this project are to 1) develop motion robust DCI to evaluate
altered brain microstructure and connectivity in perinatal stroke; 2) develop motion-robust technology for SWI
for the fetus and newborn; and 3) develop motion-robust MRA for the fetus and newborn. These contributions
are important because they will 1) enable in-vivo high-resolution imaging of the neurovascular structure, brain
network, and injury in the fetal and newborn brain; and 2) significantly improve the use of advanced MRI
technologies to assess perinatal stroke and brain development following perinatal stroke, both in the clinic and
in research settings. The technology developed and knowledge obtained from this study will lead to improved
diagnosis and prognosis of perinatal stroke, and will significantly improve studies and trials that aim to reduce
the burden of related neurological disorders such as cerebral palsy and epilepsy through timely therapeutic
interventions, i.e., anticoagulant therapy, stem cell therapies, brain hypothermia, brain stimulation, and
developmental and educational therapies.
围产期卒中显微结构和血管神经影像学研究进展
项目成果
期刊论文数量(1)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
Brain Injury in Fetuses with Vein of Galen Malformation and Nongalenic Arteriovenous Fistulas: Static Snapshot or a Portent of More?
盖伦静脉畸形和非盖伦动静脉瘘胎儿脑损伤:静态快照还是更多预兆?
- DOI:10.3174/ajnr.a7533
- 发表时间:2022
- 期刊:
- 影响因子:0
- 作者:Jaimes,C;Machado-Rivas,F;Chen,K;Bedoya,MA;Yang,E;Orbach,DB
- 通讯作者:Orbach,DB
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ALI GHOLIPOUR-BABOLI其他文献
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{{ truncateString('ALI GHOLIPOUR-BABOLI', 18)}}的其他基金
Imaging early development of human neural circuits
人类神经回路早期发育的成像
- 批准号:
10503458 - 财政年份:2022
- 资助金额:
$ 34.85万 - 项目类别:
Imaging early development of human neural circuits
人类神经回路早期发育的成像
- 批准号:
10684840 - 财政年份:2022
- 资助金额:
$ 34.85万 - 项目类别:
Enhanced Imaging of the Fetal Brain Microstructure
胎儿脑微结构的增强成像
- 批准号:
10580011 - 财政年份:2022
- 资助金额:
$ 34.85万 - 项目类别:
Enhanced Imaging of the Fetal Brain Microstructure
胎儿脑微结构的增强成像
- 批准号:
10345136 - 财政年份:2022
- 资助金额:
$ 34.85万 - 项目类别:
Advancing microstructural and vascular neuroimaging in perinatal stroke
推进围产期卒中的微观结构和血管神经影像学
- 批准号:
10332741 - 财政年份:2019
- 资助金额:
$ 34.85万 - 项目类别:
Motion-robust super-resolution diffusion weighted MRI of early brain development
早期大脑发育的运动稳健超分辨率扩散加权 MRI
- 批准号:
9284277 - 财政年份:2014
- 资助金额:
$ 34.85万 - 项目类别:
Motion-robust super-resolution diffusion weighted MRI of early brain development
早期大脑发育的运动稳健超分辨率扩散加权 MRI
- 批准号:
8764291 - 财政年份:2014
- 资助金额:
$ 34.85万 - 项目类别:
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