Biological Embedding of Childhood Obesity: Stress Responsive Systems and Sleep

儿童肥胖的生物嵌入：压力反应系统和睡眠

• 批准号: 10554095
• 负责人: Tiffany Phu
• 金额: $ 2.52万
• 依托单位: UNIVERSITY OF DENVER (COLORADO SEMINARY)
• 依托单位国家: 美国
• 财政年份: 2022
• 资助国家: 美国
• 起止时间: 2022-01-01 至 2023-08-05
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10554095
• 关键词: Address; Adolescent; Adrenal Glands; Adult; Animals; Attention; Behavior Therapy; Behavioral; Biological; Biological Assay; Biological Markers; Biological Process; Biology; Body mass index; Child; Child Health; Childhood; Clinical; Communities; Data; Dedications; Development; Dissociation; Elements; Faculty; Family; Fellowship; Functional Magnetic Resonance Imaging; Goals; Grant; Health; Hormonal; Human; Hydrocortisone; Hypothalamic structure; Infant; Intervention; Learning Skill; Literature; Measures; Methodology; Modeling; Nursery Schools; Obesity; Output; Overweight; Pathway interactions; Perception; Physical activity; Physiological; Physiology; Pituitary Gland; Positioning Attribute; Prevention; Prevention program; Productivity; Psychology; Reaction; Research; Risk; Risk Assessment; Role; Running; Salivary; School-Age Population; Scientist; Sleep; Sleep Apnea Syndromes; Standardization; Statistical Models; Stress; System; Testing; Toddler; Training; Training Activity; United States; Universities; Writing; alpha-amylase; biological systems; career; community partnership; contextual factors; design; developmental psychobiology; early childhood; effective intervention; experience; high body mass index; hypothalamic-pituitary-adrenal axis; indexing; infancy; inflammatory marker; interest; longitudinal design; middle childhood; multidimensional data; negative affect; neglect; nutrition; obesity in children; obesity prevention; obesity risk; obesogenic; overweight child; poor sleep; predictive modeling; programs; response; saliva sample; skills; sleep behavior; sleep health; sleep quality; stress reactivity; stressor

PROJECT SUMMARY/ABSTRACT About a fifth of U.S. children are obese. Pediatric obesity has significant long-term ramifications for adult health. Despite federal initiatives targeting physical activity and nutrition, rates of pediatric obesity have not significantly decreased in the last two decades. This warrants increased attention to factors instantiating risk for later obesity. Few studies examining stress biology and child obesity utilize longitudinal designs, objective measures of stress, or integrate across multiple biological systems despite increasing acknowledgement of their complicated interplay. The current proposal seeks to address gaps in the literature by integrating several biological and developmental systems during early childhood into a predictive model for later overweight/ obesity. Biological systems of interest include the Sympathetic Adrenal-Medullary (SAM) System, which quickly triggers physiologic and behavioral reactions to stressors, and Hypothalamic-Pituitary-Adrenal (HPA) Axis, a hormonal response system reacting to longer-term stressors. This study utilizes collected data (RC1DK086376 PI: Lumeng/Miller) to examine: (1) pathways between SAM system and HPA Axis functioning during a standardized stress task in toddlers and body-mass index (BMI) in middle childhood, (2) bi-directional longitudinal associations between behavioral sleep quality and BMI across preschool to middle childhood, and (3) the moderating role of behavioral sleep quality in longitudinal relationships between SAM system and HPA axis stress reactivity in preschool and BMI in middle childhood. Children provided saliva samples throughout a standardized stress task, from which cortisol (primary output of the HPA axis) and alpha amylase (indicating SAM system activity) were assayed. Results will elucidate early biological embedding of risk for overweight/ obesity and can inform concurrent type and timing of effective interventions. An extensive training plan has been designed alongside the current study to equip the applicant with skills needed for an independent research career as a clinical scientist. Fellowship training goals are to: (1) Refine distinct research interests and position for a clinical scientist career leading to an impactful research program, (2) Learn skills needed to independently run a lab, (3) Hone skills in statistical modeling suited for longitudinal, multi-dimensional data representing several biological systems, (4) Build productive, bi-directional community partnerships and skills in disseminating research, and (5) Develop grant-writing skills. The applicant has assembled a dedicated, inter- disciplinary team of scientists with relevant expertise in sleep, stress biology, obesogenic pathways, family contextual factors, and community-academic partnerships. Training activities will primarily occur in the Depart- ment of Psychology, University of Denver, where faculty conduct interdisciplinary, developmental psycho- biology research using a variety of methodologies (e.g., fMRI, inflammatory markers). This training grant will catalyze an independent research program investigating critical intersections of sleep, stress, and child health.

项目概要/摘要 大约五分之一的美国儿童肥胖。儿童肥胖对成人有显着的长期影响 健康。尽管联邦采取了针对身体活动和营养的举措，但儿童肥胖率并未下降 近二十年来显着下降。这需要更多地关注引发风险的因素 为了以后的肥胖。很少有研究利用纵向设计来研究压力生物学和儿童肥胖，客观 尽管人们越来越认识到压力的测量，或跨多个生物系统进行整合 他们复杂的相互作用。当前的提案旨在通过整合几个方面来解决文献中的空白 幼儿期的生物和发育系统转化为以后超重的预测模型/ 肥胖。感兴趣的生物系统包括交感肾上腺髓质 (SAM) 系统，它可以快速 触发对压力源和下丘脑-垂体-肾上腺 (HPA) 轴的生理和行为反应， 荷尔蒙反应系统对长期压力源做出反应。本研究利用收集的数据 (RC1DK086376 PI：Lumeng/Miller）检查：(1) SAM 系统和 HPA 轴功能之间的通路 幼儿标准化压力任务和童年中期体重指数 (BMI)，(2) 双向 学龄前至中期的行为睡眠质量与体重指数之间的纵向关联，以及 (3)行为睡眠质量在SAM系统与HPA纵向关系中的调节作用 学龄前的轴应激反应和童年中期的体重指数。孩子们在整个过程中提供了唾液样本 标准化压力任务，其中皮质醇（HPA 轴的主要输出）和 α 淀粉酶（表明 SAM 系统活性）进行了测定。结果将阐明超重/超重风险的早期生物嵌入 肥胖，并可以告知有效干预措施的并发类型和时机。广泛的培训计划 与当前的研究一起设计，以使申请人具备独立所需的技能 作为临床科学家的研究生涯。研究员培训目标是：（1）提炼独特的研究兴趣 以及临床科学家职业生涯的职位，从而开展有影响力的研究计划，(2) 学习以下技能： 独立运行实验室，（3）磨练适合纵向、多维数据的统计建模技能 代表多个生物系统，(4) 建立高效、双向的社区伙伴关系和技能 传播研究成果，以及 (5) 培养拨款写作技能。申请人已经组建了一个专门的、内部的 由在睡眠、压力生物学、肥胖途径、家庭等领域具有相关专业知识的科学家组成的学科团队 背景因素以及社区与学术伙伴关系。培训活动将主要在部门进行 丹佛大学心理学系，教师们开展跨学科的发展心理学研究 使用各种方法（例如功能磁共振成像、炎症标记物）的生物学研究。这笔培训补助金将 推动一项独立研究计划，调查睡眠、压力和儿童健康之间的关键交叉点。