Biological Embedding of Childhood Obesity: Stress Responsive Systems and Sleep

儿童肥胖的生物嵌入：压力反应系统和睡眠

• 批准号: 10554095
• 负责人: Tiffany Phu
• 金额: $ 2.52万
• 依托单位: UNIVERSITY OF DENVER (COLORADO SEMINARY)
• 依托单位国家: 美国
• 财政年份: 2022
• 资助国家: 美国
• 起止时间: 2022-01-01 至 2023-08-05
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10554095
• 关键词: Address; Adolescent; Adrenal Glands; Adult; Animals; Attention; Behavior Therapy; Behavioral; Biological; Biological Assay; Biological Markers; Biological Process; Biology; Body mass index; Child; Child Health; Childhood; Clinical; Communities; Data; Dedications; Development; Dissociation; Elements; Faculty; Family; Fellowship; Functional Magnetic Resonance Imaging; Goals; Grant; Health; Hormonal; Human; Hydrocortisone; Hypothalamic structure; Infant; Intervention; Learning Skill; Literature; Measures; Methodology; Modeling; Nursery Schools; Obesity; Output; Overweight; Pathway interactions; Perception; Physical activity; Physiological; Physiology; Pituitary Gland; Positioning Attribute; Prevention; Prevention program; Productivity; Psychology; Reaction; Research; Risk; Risk Assessment; Role; Running; Salivary; School-Age Population; Scientist; Sleep; Sleep Apnea Syndromes; Standardization; Statistical Models; Stress; System; Testing; Toddler; Training; Training Activity; United States; Universities; Writing; alpha-amylase; biological systems; career; community partnership; contextual factors; design; developmental psychobiology; early childhood; effective intervention; experience; high body mass index; hypothalamic-pituitary-adrenal axis; indexing; infancy; inflammatory marker; interest; longitudinal design; middle childhood; multidimensional data; negative affect; neglect; nutrition; obesity in children; obesity prevention; obesity risk; obesogenic; overweight child; poor sleep; predictive modeling; programs; response; saliva sample; skills; sleep behavior; sleep health; sleep quality; stress reactivity; stressor

PROJECT SUMMARY/ABSTRACT About a fifth of U.S. children are obese. Pediatric obesity has significant long-term ramifications for adult health. Despite federal initiatives targeting physical activity and nutrition, rates of pediatric obesity have not significantly decreased in the last two decades. This warrants increased attention to factors instantiating risk for later obesity. Few studies examining stress biology and child obesity utilize longitudinal designs, objective measures of stress, or integrate across multiple biological systems despite increasing acknowledgement of their complicated interplay. The current proposal seeks to address gaps in the literature by integrating several biological and developmental systems during early childhood into a predictive model for later overweight/ obesity. Biological systems of interest include the Sympathetic Adrenal-Medullary (SAM) System, which quickly triggers physiologic and behavioral reactions to stressors, and Hypothalamic-Pituitary-Adrenal (HPA) Axis, a hormonal response system reacting to longer-term stressors. This study utilizes collected data (RC1DK086376 PI: Lumeng/Miller) to examine: (1) pathways between SAM system and HPA Axis functioning during a standardized stress task in toddlers and body-mass index (BMI) in middle childhood, (2) bi-directional longitudinal associations between behavioral sleep quality and BMI across preschool to middle childhood, and (3) the moderating role of behavioral sleep quality in longitudinal relationships between SAM system and HPA axis stress reactivity in preschool and BMI in middle childhood. Children provided saliva samples throughout a standardized stress task, from which cortisol (primary output of the HPA axis) and alpha amylase (indicating SAM system activity) were assayed. Results will elucidate early biological embedding of risk for overweight/ obesity and can inform concurrent type and timing of effective interventions. An extensive training plan has been designed alongside the current study to equip the applicant with skills needed for an independent research career as a clinical scientist. Fellowship training goals are to: (1) Refine distinct research interests and position for a clinical scientist career leading to an impactful research program, (2) Learn skills needed to independently run a lab, (3) Hone skills in statistical modeling suited for longitudinal, multi-dimensional data representing several biological systems, (4) Build productive, bi-directional community partnerships and skills in disseminating research, and (5) Develop grant-writing skills. The applicant has assembled a dedicated, inter- disciplinary team of scientists with relevant expertise in sleep, stress biology, obesogenic pathways, family contextual factors, and community-academic partnerships. Training activities will primarily occur in the Depart- ment of Psychology, University of Denver, where faculty conduct interdisciplinary, developmental psycho- biology research using a variety of methodologies (e.g., fMRI, inflammatory markers). This training grant will catalyze an independent research program investigating critical intersections of sleep, stress, and child health.

项目总结/文摘