Biological Embedding of Childhood Obesity: Stress Responsive Systems and Sleep

儿童肥胖的生物嵌入：压力反应系统和睡眠

• 批准号: 10389563
• 负责人: Tiffany Phu
• 金额: $ 3.53万
• 依托单位: UNIVERSITY OF DENVER (COLORADO SEMINARY)
• 依托单位国家: 美国
• 财政年份: 2022
• 资助国家: 美国
• 起止时间: 2022-01-01 至 2023-12-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10389563
• 关键词: Address; Adolescent; Adrenal Glands; Adult; Animals; Attention; Behavior Therapy; Behavioral; Biological; Biological Assay; Biological Markers; Biological Process; Biology; Body mass index; Child; Child Health; Childhood; Clinical; Communities; Data; Development; Dissociation; Elements; Faculty; Family; Fellowship; Foundations; Functional Magnetic Resonance Imaging; Goals; Grant; Health; Hormonal; Human; Hydrocortisone; Hypothalamic structure; Infant; Intervention; Lead; Learning Skill; Literature; Measures; Methodology; Modeling; Nursery Schools; Obesity; Output; Overweight; Pathway interactions; Perception; Physical activity; Physiological; Physiology; Pituitary Gland; Positioning Attribute; Prevention; Prevention program; Psychology; Reaction; Research; Risk; Risk Assessment; Role; Running; Salivary; School-Age Population; Scientist; Sleep; Sleep Apnea Syndromes; Standardization; Statistical Models; Stress; System; Testing; Toddler; Training; Training Activity; United States; Universities; Writing; abuse neglect; alpha-amylase; biological systems; career; community partnership; contextual factors; design; developmental psychobiology; early childhood; effective intervention; experience; high body mass index; hypothalamic-pituitary-adrenal axis; indexing; infancy; inflammatory marker; interest; longitudinal design; middle childhood; multidimensional data; negative affect; nutrition; obesity in children; obesity prevention; obesity risk; obesogenic; overweight child; poor sleep; predictive modeling; programs; response; saliva sample; skills; sleep behavior; sleep health; sleep quality; stress reactivity; stressor

PROJECT SUMMARY/ABSTRACT About a fifth of U.S. children are obese. Pediatric obesity has significant long-term ramifications for adult health. Despite federal initiatives targeting physical activity and nutrition, rates of pediatric obesity have not significantly decreased in the last two decades. This warrants increased attention to factors instantiating risk for later obesity. Few studies examining stress biology and child obesity utilize longitudinal designs, objective measures of stress, or integrate across multiple biological systems despite increasing acknowledgement of their complicated interplay. The current proposal seeks to address gaps in the literature by integrating several biological and developmental systems during early childhood into a predictive model for later overweight/ obesity. Biological systems of interest include the Sympathetic Adrenal-Medullary (SAM) System, which quickly triggers physiologic and behavioral reactions to stressors, and Hypothalamic-Pituitary-Adrenal (HPA) Axis, a hormonal response system reacting to longer-term stressors. This study utilizes collected data (RC1DK086376 PI: Lumeng/Miller) to examine: (1) pathways between SAM system and HPA Axis functioning during a standardized stress task in toddlers and body-mass index (BMI) in middle childhood, (2) bi-directional longitudinal associations between behavioral sleep quality and BMI across preschool to middle childhood, and (3) the moderating role of behavioral sleep quality in longitudinal relationships between SAM system and HPA axis stress reactivity in preschool and BMI in middle childhood. Children provided saliva samples throughout a standardized stress task, from which cortisol (primary output of the HPA axis) and alpha amylase (indicating SAM system activity) were assayed. Results will elucidate early biological embedding of risk for overweight/ obesity and can inform concurrent type and timing of effective interventions. An extensive training plan has been designed alongside the current study to equip the applicant with skills needed for an independent research career as a clinical scientist. Fellowship training goals are to: (1) Refine distinct research interests and position for a clinical scientist career leading to an impactful research program, (2) Learn skills needed to independently run a lab, (3) Hone skills in statistical modeling suited for longitudinal, multi-dimensional data representing several biological systems, (4) Build productive, bi-directional community partnerships and skills in disseminating research, and (5) Develop grant-writing skills. The applicant has assembled a dedicated, inter- disciplinary team of scientists with relevant expertise in sleep, stress biology, obesogenic pathways, family contextual factors, and community-academic partnerships. Training activities will primarily occur in the Depart- ment of Psychology, University of Denver, where faculty conduct interdisciplinary, developmental psycho- biology research using a variety of methodologies (e.g., fMRI, inflammatory markers). This training grant will catalyze an independent research program investigating critical intersections of sleep, stress, and child health.

项目摘要/摘要 大约五分之一的美国儿童肥胖。小儿肥胖对成人具有显着的长期影响 健康。尽管联邦针对体育锻炼和营养的举措，但小儿肥胖率却没有 在过去的二十年中，大幅下降。这需要增加对实例化风险因素的关注 以后的肥胖。很少有研究压力生物学和儿童肥胖的研究，利用纵向设计，客观 尽管认可 他们复杂的相互作用。当前的提议旨在通过整合几个来解决文献中的差距 幼儿期间的生物学和发育系统，成为一个预测模型，以供以后超重/ 肥胖。感兴趣的生物学系统包括交感神经 - 肾上腺 - 甲壳虫（SAM）系统，该系统迅速 触发对压力源的生理和行为反应，以及下丘脑 - 垂体 - 肾上腺（HPA）轴，A 激素反应系统与长期应激源反应。这项研究利用收集的数据（RC1DK086376 PI：Lumeng/Miller）检查：（1）SAM系统和HPA轴之间运行期间运行的途径 幼儿中的幼儿和身体质量指数（BMI）的标准化压力任务（2）双向 行为睡眠质量与BMI之间的纵向关联，幼儿园到中学，以及 （3）行为睡眠质量在SAM系统与HPA之间的纵向关系中的调节作用 童年时期的轴心应力反应性。孩子们在整个过程中提供了唾液样本 标准化的压力任务，皮质醇（HPA轴的主要输出）和α淀粉酶（指示 分析SAM系统活动）。结果将阐明早期生物学嵌入超重/ 肥胖，可以告知有效干预措施的同时类型和时间。广泛的培训计划 是与当前研究一起设计的，以使申请人拥有独立的技能 作为临床科学家的研究职业。奖学金培训目标是：（1）完善独特的研究兴趣 和临床科学家职业的职位，导致有影响力的研究计划，（2）学习所需的技能 独立运行实验室，（3）适合纵向多维数据的统计建模技能 代表几种生物系统，（4）建立生产力，双向社区伙伴关系和技能 在传播研究和（5）发展授予写作技巧时。申请人组装了专用的，间 纪律在睡眠，压力生物学，肥胖途径，家庭方面具有相关专业知识的科学家团队 上下文因素和社区学术伙伴关系。培训活动主要发生在部门 丹佛大学心理学的精神学，教师在跨学科，发展心理学进行跨学科 生物学研究使用了多种方法（例如FMRI，炎症标记）。这项培训赠款将 催化一个独立的研究计划，研究了睡眠，压力和儿童健康的关键交叉点。