Core 1: Integrated Pathology and Radiology Core (iPRC)

核心 1：综合病理学和放射学核心 (iPRC)

• 批准号: 10555403
• 负责人: Wei Huang
• 金额: $ 31.94万
• 依托单位: UNIVERSITY OF WISCONSIN-MADISON
• 依托单位国家: 美国
• 财政年份: 2023
• 资助国家: 美国
• 起止时间: 2023-07-01 至 2028-06-30
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10555403
• 关键词: 3-Dimensional; Address; Bioinformatics; Biological Markers; Body Fluids; Cancer Center; Cancer Patient; Cancer Research Project; Clinical; Clinical Trials; Collaborations; Communities; Consultations; Correlation Studies; Data; Databases; Dedications; FOLH1 gene; Formalin; Freezing; Future; Goals; Hematoxylin and Eosin Staining Method; Histologic; Histology; Histopathology; Image; Immunofluorescence Immunologic; Immunohistochemistry; Infrastructure; Lesion; Link; Localized Lesion; Magnetic Resonance Imaging; Malignant neoplasm of prostate; Mission; Molds; Neoplasm Circulating Cells; Neoplasm Metastasis; Organoids; Paraffin Embedding; Pathology; Peripheral Blood Mononuclear Cell; Plasma; Positron-Emission Tomography; Process; Prostate; Prostatectomy; Radiation therapy; Radiology Specialty; Reproducibility; Research Personnel; Resistance; Resources; Services; Stains; Technology; Tissue Embedding; Tissue Microarray; Tissues; Treatment outcome; Tumor Pathology; Universities; Wisconsin; anticancer research; cancer imaging; castration resistant prostate cancer; clinically significant; design; digital; image archival system; image translation; pathology imaging; patient derived xenograft model; preservation; prostate cancer cell; quantitative imaging; radiological imaging; repository; treatment response; tumor; whole slide imaging

PROJECT SUMMARY The Integrated Pathology Radiology Core (iPRC) of the UW Prostate Cancer SPORE is dedicated to providing expert and reliable pathology and imaging services to enhance translational prostate cancer (PC) research. The theme of this core is to provide our UW Prostate Cancer SPORE investigators with a wide range of integrated and coordinated pathology and radiology services including high quality and extensively annotated biospecimens, state-of-the-art pathology, and advanced radiology imaging. The iPRC will provide services and infrastructure to allow for reliable, reproducible, and high-quality pathology data to be linked with radiologic imaging tumor identification and lesion-to-lesion correlation. This will integrate pathology-radiology data and be linked to comprehensive clinical information as well as tumor-specific bioinformatics. The mission of the iPRC is to provide the type and quality of services that will enable Prostate Cancer SPORE investigators to address pathology, radiology, and quantitative imaging translational aims as well as generate reliable and clinically significant findings that will impact treatment outcomes. Successful accomplishment of many of the translational aims of the Prostate Cancer SPORE projects is dependent on the iPRC services. The specific aims of the iPRC are strategically designed to produce a core service unique from existing cancer center cores that will directly meet the needs of the Prostate Cancer SPORE projects and build a sustainable central organizing force for future translational PC research. The unique infrastructure and resources created to support the UW Prostate Cancer SPORE projects will provide an integrated pathology and radiology database repository to benefit collaborative translational PC research projects at UW and the wider PC research community.

项目摘要 UW前列腺癌孢子的综合病理放射学核心（IPRC）致力于提供 专家和可靠的病理和成像服务，以增强前列腺癌（PC）研究。这 该核心的主题是为我们的UW前列腺癌孢子研究人员提供广泛的综合 以及协调的病理学和放射学服务，包括高质量和广泛注释 生物测量，最先进的病理学和先进的放射学成像。 IPRC将提供服务和 基础架构允许可靠，可重复和高质量的病理数据与放射线联系起来 成像肿瘤鉴定和病变与衰老的相关性。这将整合病理 - 放射学数据并成为 与综合临床信息以及肿瘤特异性生物信息学有关。 IPRC的任务是 提供服务的类型和质量，以使前列腺癌孢子调查人员能够解决 病理学，放射学和定量成像翻译目的以及可靠和临床上产生 会影响治疗结果的重要发现。成功完成许多翻译 前列腺癌孢子项目的目的取决于IPRC服务。 IPRC的具体目的 战略性设计旨在从现有的癌症中心核心提供独特的核心服务，该服务将直接直接 满足前列腺癌孢子项目的需求，并为 未来的翻译PC研究。为支持UW前列腺而创建的独特基础架构和资源 癌症孢子项目将提供综合病理学和放射学数据库存储库 UW和更广泛的PC研究社区的合作转化PC研究项目。