Core 1: Integrated Pathology and Radiology Core (iPRC)

核心 1：综合病理学和放射学核心 (iPRC)

• 批准号: 10555403
• 负责人: Wei Huang
• 金额: $ 31.94万
• 依托单位: UNIVERSITY OF WISCONSIN-MADISON
• 依托单位国家: 美国
• 财政年份: 2023
• 资助国家: 美国
• 起止时间: 2023-07-01 至 2028-06-30
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10555403
• 关键词: 3-Dimensional; Address; Bioinformatics; Biological Markers; Body Fluids; Cancer Center; Cancer Patient; Cancer Research Project; Clinical; Clinical Trials; Collaborations; Communities; Consultations; Correlation Studies; Data; Databases; Dedications; FOLH1 gene; Formalin; Freezing; Future; Goals; Hematoxylin and Eosin Staining Method; Histologic; Histology; Histopathology; Image; Immunofluorescence Immunologic; Immunohistochemistry; Infrastructure; Lesion; Link; Localized Lesion; Magnetic Resonance Imaging; Malignant neoplasm of prostate; Mission; Molds; Neoplasm Circulating Cells; Neoplasm Metastasis; Organoids; Paraffin Embedding; Pathology; Peripheral Blood Mononuclear Cell; Plasma; Positron-Emission Tomography; Process; Prostate; Prostatectomy; Radiation therapy; Radiology Specialty; Reproducibility; Research Personnel; Resistance; Resources; Services; Stains; Technology; Tissue Embedding; Tissue Microarray; Tissues; Treatment outcome; Tumor Pathology; Universities; Wisconsin; anticancer research; cancer imaging; castration resistant prostate cancer; clinically significant; design; digital; image archival system; image translation; pathology imaging; patient derived xenograft model; preservation; prostate cancer cell; quantitative imaging; radiological imaging; repository; treatment response; tumor; whole slide imaging

PROJECT SUMMARY The Integrated Pathology Radiology Core (iPRC) of the UW Prostate Cancer SPORE is dedicated to providing expert and reliable pathology and imaging services to enhance translational prostate cancer (PC) research. The theme of this core is to provide our UW Prostate Cancer SPORE investigators with a wide range of integrated and coordinated pathology and radiology services including high quality and extensively annotated biospecimens, state-of-the-art pathology, and advanced radiology imaging. The iPRC will provide services and infrastructure to allow for reliable, reproducible, and high-quality pathology data to be linked with radiologic imaging tumor identification and lesion-to-lesion correlation. This will integrate pathology-radiology data and be linked to comprehensive clinical information as well as tumor-specific bioinformatics. The mission of the iPRC is to provide the type and quality of services that will enable Prostate Cancer SPORE investigators to address pathology, radiology, and quantitative imaging translational aims as well as generate reliable and clinically significant findings that will impact treatment outcomes. Successful accomplishment of many of the translational aims of the Prostate Cancer SPORE projects is dependent on the iPRC services. The specific aims of the iPRC are strategically designed to produce a core service unique from existing cancer center cores that will directly meet the needs of the Prostate Cancer SPORE projects and build a sustainable central organizing force for future translational PC research. The unique infrastructure and resources created to support the UW Prostate Cancer SPORE projects will provide an integrated pathology and radiology database repository to benefit collaborative translational PC research projects at UW and the wider PC research community.

项目总结 UW前列腺癌孢子的综合病理放射核心(IPRC)致力于提供 专业可靠的病理和影像服务，以加强转化性前列腺癌(PC)研究。这个 这一核心的主题是为我们的UW前列腺癌孢子研究人员提供广泛的综合 以及协调的病理学和放射学服务，包括高质量和广泛注释 生物显微镜、最先进的病理学和先进的放射成像。综合资源中心将提供服务和 允许可靠、可重复且高质量的病理数据与放射学相关联的基础设施 影像肿瘤识别和病变与病变的相关性。这将整合病理学-放射学数据，并 链接到全面的临床信息以及特定于肿瘤的生物信息学。创新研究中心的使命是 提供使前列腺癌孢子研究人员能够解决的服务类型和质量 病理学、放射学和定量成像的翻译目标以及产生可靠和临床 将影响治疗结果的重大发现。成功地完成了许多翻译工作 前列腺癌孢子项目的目标依赖于国际癌症研究中心的服务。独立审查委员会的具体目标 是战略性设计的，旨在产生一种不同于现有癌症中心核心的核心服务，将直接 满足前列腺癌孢子项目需求，构建可持续发展的中央组织力量 未来的翻译PC研究。为支持威斯康星州前列腺癌而创建的独特基础设施和资源 癌症孢子项目将提供一个综合的病理学和放射学数据库存储库，以受益 威斯康星大学和更广泛的个人电脑研究社区的合作翻译个人电脑研究项目。