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Causal role of higher-order thalamo-cortical oscillations in sustained attention

高阶丘脑皮质振荡在持续注意力中的因果作用

基本信息

批准号：
10199754
负责人：
Wei Huang
金额：
$ 3.68万
依托单位：
UNIV OF NORTH CAROLINA CHAPEL HILL
依托单位国家：
美国
项目类别：
财政年份：
2019
资助国家：
美国
起止时间：
2019-07-01 至 2022-05-15
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/10199754
关键词：
Anatomy Animal Model Animals Attention Attention deficit hyperactivity disorder Attentional deficit Behavior Behavioral Bipolar Disorder Cognition Cognitive Cognitive deficits Communication Communities Computers Conflict (Psychology)Couples Data Dorsal Electrophysiology (science)Exhibits Ferrets Foundations Frequencies Functional disorder Impairment Implant Impulsivity Investigation Lasers Lateral Lateral posterior nucleus of thalamus Length Link Machine Learning Maps Mediating Mental disorders Methods Microelectrodes Modeling Neurons Parietal Parietal Lobe Performance Periodicity Phase Physiologic pulse Prefrontal Cortex Process Psyche structure Reaction Time Research Resources Rewards Role Schizophrenia Signal Transduction Statistical Models Stimulus Structure Techniques Testing Thalamic structure Therapeutic Time Touch sensation Training Visual Visual Cortex Work area striata base behavioral outcome calmodulin-dependent protein kinase II cognitive control cognitive function functional disability innovation neurotransmission novel optogenetics recruit relating to nervous system sensor sensory cortex signal processing sustained attention theories tool visual stimulus

项目摘要

PROPOSAL SUMMARY/ABSTRACT Sustained attention – the continuous allocation of cognitive resources to respond to infrequent but behaviorally relevant stimuli – is impaired in many psychiatric disorders and represents an important aspect of cognitive control. Sustained attention requires top-down control and engagement with the external world, which is linked to both frontoparietal and thalamic controlling signals on primary sensor cortices. Despite the extensive behavioral characterization of sustained attention in animal models using the five-choice serial reaction time task (5-CSRTT), very little is known about the oscillatory interaction between the dorsal attention network and thalamo-cortical dynamics and its potential as a stimulation target for enhancing sustained attention. The objective of this project is to dissect the causal role of higher-order thalamo-cortical oscillations in sustained attention via temporally-precise rhythmic stimulation. I will focus on three regions in the visual thalamo-cortical network: higher-order visual thalamus (lateral aspect of lateral posterior nucleus, LPl), posterior parietal cortex (PPC), and primary visual cortex (V1). I will test the central hypothesis that LPl-cortical theta (4-7 Hz) functional connectivity causally coordinates PPC-V1 functional connectivity to facilitate sustained attention. The rationale of this work is that the proposed temporally-precise rhythmic optogenetic perturbations will directly test the causal role of thalamo-cortical functional connectivity in sustained attention. Accordingly, the two specific aims are: (1) Delineate the functional role of higher-order thalamo-cortical oscillations in sustained attention, (2) Determine the causal role of thalamo-cortical functional connectivity in sustained attention via temporally-precise rhythmic optogenetics. This work is significant because it will causally test a convergent model in which higher-order visual thalamus coordinates the parietal top-down control signals onto visual cortex that is crucial for developing circuit- based therapies to enhance sustained attention. The work is innovative due to its integration of closed-loop optogenetics circuit interrogation, multisite electrophysiology, freely-moving sustained attention task, and machine-learning tools for the investigation of the causal role of oscillatory synchronization. The overall positive impact of the proposed study is to provide a more comprehensive map of how the higher-order visual thalamus interacts with the frontoparietal control signal to modulate V1, and thus mediates sustained attention, a transdiagnostic cognitive function that shows impairment in many psychiatric disorders including attention deficit hyperactivity disorder, bipolar disorder, and schizophrenia. The implication of this study is that it may reveal a general mechanism underlying the interaction between two higher-order processing structures signaling to lower sensory cortices during cognitive processing.

建议总结/文摘