The Emory Healthy Brain Study: Discovering Predictive Biomarkers for Alzheimer's Disease

埃默里健康大脑研究：发现阿尔茨海默病的预测生物标志物

• 批准号: 10555203
• 负责人: JAMES J LAH
• 金额: $ 701.17万
• 依托单位: EMORY UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2021
• 资助国家: 美国
• 起止时间: 2021-02-15 至 2026-01-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10555203
• 关键词: Acceleration; Address; African American; African American population; Age; Alzheimer disease detection; Alzheimer' s Disease; Alzheimer' s disease pathology; Alzheimer' s disease related dementia; Alzheimer’s disease biomarker; Amyloid beta-42; Amyloid beta-Protein; Area; Biological Markers; Blood; Blood Vessels; Brain; Cardiovascular Diseases; Cardiovascular Physiology; Carotid Atherosclerotic Disease; Caucasians; Central Nervous System; Cerebrospinal Fluid; Cerebrospinal Fluid Proteins; Characteristics; Chronic Disease; Classification; Clinical; Cognitive; Collection; Data; Detection; Diagnosis; Disease; Enrollment; Etiology; Evolution; Exposure to; Frequencies; Functional disorder; Future; Genotype; Goals; Hormone replacement therapy; Immunity; Impaired cognition; Individual; Inflammation; Intervention; Longitudinal Studies; MRI Scans; Magnetic Resonance Imaging; Magnetic Resonance Spectroscopy; Measurement; Measures; Metabolic; Myelin; Neurons; Participant; Pathology; Patients; Phenotype; Positron-Emission Tomography; Prevention trial; Preventive treatment; Proteins; Proteomics; Race; Research; Research Personnel; Resources; Risk; Role; Science; Sex Differences; Statistical Methods; Subgroup; Symptoms; Synapses; Techniques; Testing; Time; Tracer; Work; aged; arterial stiffness; asymptomatic Alzheimer' s disease; biomarker discovery; biomarker identification; brain magnetic resonance imaging; candidate identification; candidate marker; cardiovascular disorder risk; cerebrovascular; clinical phenotype; clinical practice; cognitive testing; cohort; data sharing; effective therapy; follow-up; high risk; imaging modality; immune function; longitudinal analysis; magnetic resonance imaging biomarker; middle age; myelination; neuroinflammation; novel marker; pre-clinical; predictive marker; predictive test; prevent; progression risk; protein biomarkers; racial diversity; recruit; risk prediction; sex; support tools; symptom treatment; tau Proteins; tool

Abstract/Summary Progress in understanding Alzheimer’s disease and related disorders (ADRD) is close to producing more effective treatments, creating an urgent need for disease-predictive biomarkers to guide their use. Using cerebrospinal fluid (CSF) measurements of beta-amyloid and Tau and positron-emission tomography tracers, we can detect AD pathology in cognitively normal individuals. However, current tools do not allow us to predict when or even if an individual with asymptomatic pathology will develop symptoms. To address this need, we propose to longitudinally study ≥3000 cognitively normal individuals (50-75 years at enrollment) in the Emory Healthy Brain Study to define the frequency of asymptomatic AD and rates of cognitive decline in a racially diverse cohort of healthy individuals (Specific Aim 1). An important goal of Aim 1 is to achieve ≥33% African- American participants to provide sufficient power to address questions regarding race- and sex-dependent differences in biomarkers and risk of cognitive decline. Participants will be phenotyped biennially with cognitive testing, cardiovascular physiology, brain MRI, and blood and CSF collection. Cross-sectional (Specific Aim 2) and longitudinal analyses (Specific Aim 3) will test the hypothesis that biomarkers of synaptic, vascular, myelination, glial immunity, and metabolic functions will identify subgroups who are at greatest risk of progressing to symptomatic AD. Candidate biomarkers will be identified through state-of-the-art proteomics, MR imaging, and statistical methods. A highly collaborative data and biospecimen sharing plan will allow other investigators to leverage these resources to advance a broad spectrum of ADRD research.

抽象/总结