Core B: Clinical Core
核心 B:临床核心
基本信息
- 批准号:8849139
- 负责人:
- 金额:$ 37.43万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2005
- 资助国家:美国
- 起止时间:2005-06-01 至
- 项目状态:未结题
- 来源:
- 关键词:AddressAffectAfricanAfrican AmericanAlzheimer disease preventionAlzheimer&aposs DiseaseAmyloid beta-ProteinAreaAutopsyBasic ScienceBiologicalBiological MarkersBloodBlood specimenBrainCerebrospinal FluidClinicalClinical DataClinical PathologyClinical ResearchClinical TrialsCognitionCognitive agingCollectionCommunitiesCross-Sectional StudiesDataData QualityDementiaDiagnosisDiseaseEducationElderlyElementsEnrollmentEvolutionFailureFundingGeneticGenotypeGoalsHispanicsImpaired cognitionIndividualInternationalMagnetic Resonance ImagingMemory LossMulticenter StudiesNerve DegenerationNeurodegenerative DisordersOnset of illnessParticipantPathological StagingPatientsPharmaceutical PreparationsPlayPopulationPositioning AttributeProcessProductionPublic HealthRecruitment ActivityResearchResearch PersonnelResearch SupportResourcesRiskRoleSamplingSpecimenStagingSymptomsTherapeuticUnited States National Institutes of HealthWorkabstractingbasecohortcombatdata managementdrug testingeffective therapyenhancing factorimprovedinnovationmild cognitive impairmentneuroimagingneuropathologyoutreachpeptide Apre-clinicalsuccessvolunteer
项目摘要
SUMMARY/ABSTRACT: CLINICAL CORE (CORE B)
The primary goals of the Emory ADRC Clinical Core are to support and enhance research efforts to
understand the causes of Alzheimer's disease and related neurodegenerative disorders in order to develop
effective treatments. To accomplish these goals, the Clinical Core maintains a cohort of volunteers who allow
investigators to examine the process of normal and pathological cognitive aging, provide essential biological
specimens and neuroimaging data, and serve as participants in promising clinical trials. The Clinical Core
contributes to local, national, and international studies and reflects NIA-defined network-wide priorities. In the
current funding period, the Core has provided top-quality clinical data and biological samples to national
coordinating centers, and has maximized community engagement and participation of African-American older
adults in ADRC-sponsored research and related projects.
Specific Aims for this renewal are to 1) continue to maintain a cohort of well-characterized participants to
support efforts to understand normal cognitive aging and decline due to AD and related disorders; 2) develop
innovative approaches to increase the participation of African Americans in AD research; and 3) establish a
Longitudinal Biomarker Collection to support research and improve understanding of the early stages of
pathological cognitive aging. We will focus our efforts on preclinical disease and mild cognitive impairment
since treatments are more likely to be successful if implemented at an early stage. We also plan to double the
current cohort to include 50% African Americans to address stark racial imbalances in understanding clinical,
pathological, and genetic features of AD and to make data available for multicenter studies. As part of this
effort, we will collect data to define elements that improve success in recruiting and engaging African-American
research volunteers. Longitudinal biomarker sampling of blood, CSF, and neuroimaging will provide a powerful
resource since cross-sectional studies limit our ability to identify predictors of AD onset and progression. The
themes and goals that are proposed for the Clinical Core are consistent with the overall focus of the Emory
ADRC, and it will serve as a powerful proponent for basic and clinical research efforts to advance our abilities
to diagnose and treat patients suffering from AD and other neurodegenerative dementing diseases.
总结/摘要:临床核心(核心B)
埃默里ADRC临床核心的主要目标是支持和加强研究工作,
了解阿尔茨海默病和相关神经退行性疾病的原因,以便开发
有效的治疗。为了实现这些目标,临床核心维持了一批志愿者,他们允许
研究人员研究正常和病理性认知老化的过程,提供必要的生物学
标本和神经影像学数据,并作为有前途的临床试验的参与者。临床核心
有助于地方,国家和国际研究,并反映NIA定义的网络范围内的优先事项。在
在目前的资助期间,核心为国家提供了高质量的临床数据和生物样本,
协调中心,并最大限度地提高了社区参与和非洲裔美国老年人的参与
成人在ADRC赞助的研究和相关项目。
本次更新的具体目标是:1)继续保持一个特征良好的参与者队列,
支持理解正常认知老化和AD及相关疾病所致认知能力下降的努力; 2)开发
创新的方法,以增加非裔美国人在AD研究的参与;和3)建立一个
纵向生物标志物收集,以支持研究和提高对早期阶段的理解,
病理性认知老化我们将集中精力于临床前疾病和轻度认知障碍
因为如果在早期阶段实施治疗更有可能成功。我们还计划将
目前的队列包括50%的非洲裔美国人,以解决在理解临床,
AD的病理学和遗传学特征,并为多中心研究提供数据。作为其中的一部分
努力,我们将收集数据,以确定提高招聘和吸引非洲裔美国人的成功要素
研究志愿者血液、CSF和神经影像学的纵向生物标志物采样将提供强有力的
因为横断面研究限制了我们识别AD发病和进展预测因子的能力。的
为临床核心提出的主题和目标与埃默里大学的总体重点一致
ADRC,它将作为基础和临床研究工作的有力支持者,以提高我们的能力
诊断和治疗患有AD和其他神经退行性痴呆疾病的患者。
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
数据更新时间:{{ journalArticles.updateTime }}
{{
item.title }}
{{ item.translation_title }}
- DOI:
{{ item.doi }} - 发表时间:
{{ item.publish_year }} - 期刊:
- 影响因子:{{ item.factor }}
- 作者:
{{ item.authors }} - 通讯作者:
{{ item.author }}
数据更新时间:{{ journalArticles.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ monograph.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ sciAawards.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ conferencePapers.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ patent.updateTime }}
JAMES J LAH其他文献
JAMES J LAH的其他文献
{{
item.title }}
{{ item.translation_title }}
- DOI:
{{ item.doi }} - 发表时间:
{{ item.publish_year }} - 期刊:
- 影响因子:{{ item.factor }}
- 作者:
{{ item.authors }} - 通讯作者:
{{ item.author }}
{{ truncateString('JAMES J LAH', 18)}}的其他基金
Translation of GluN2B-selective PET radiopharmaceuticals in Alzheimers patients
GluN2B 选择性 PET 放射性药物在阿尔茨海默病患者中的应用
- 批准号:
10716786 - 财政年份:2023
- 资助金额:
$ 37.43万 - 项目类别:
The Emory Healthy Brain Study: Discovering Predictive Biomarkers for Alzheimer's Disease
埃默里健康大脑研究:发现阿尔茨海默病的预测生物标志物
- 批准号:
10348719 - 财政年份:2021
- 资助金额:
$ 37.43万 - 项目类别:
The Emory Healthy Brain Study: Discovering Predictive Biomarkers for Alzheimer's Disease
埃默里健康大脑研究:发现阿尔茨海默病的预测生物标志物
- 批准号:
10555203 - 财政年份:2021
- 资助金额:
$ 37.43万 - 项目类别:
ApoE Receptor LR11 in Alzheimer's Etiopathogenesis
ApoE 受体 LR11 在阿尔茨海默病发病机制中的作用
- 批准号:
6811586 - 财政年份:2004
- 资助金额:
$ 37.43万 - 项目类别:
ApoE Receptor LR11 in Alzheimer's Etiopathogenesis
ApoE 受体 LR11 在阿尔茨海默病发病机制中的作用
- 批准号:
7110266 - 财政年份:2004
- 资助金额:
$ 37.43万 - 项目类别:
相似海外基金
How Does Particle Material Properties Insoluble and Partially Soluble Affect Sensory Perception Of Fat based Products
不溶性和部分可溶的颗粒材料特性如何影响脂肪基产品的感官知觉
- 批准号:
BB/Z514391/1 - 财政年份:2024
- 资助金额:
$ 37.43万 - 项目类别:
Training Grant
BRC-BIO: Establishing Astrangia poculata as a study system to understand how multi-partner symbiotic interactions affect pathogen response in cnidarians
BRC-BIO:建立 Astrangia poculata 作为研究系统,以了解多伙伴共生相互作用如何影响刺胞动物的病原体反应
- 批准号:
2312555 - 财政年份:2024
- 资助金额:
$ 37.43万 - 项目类别:
Standard Grant
RII Track-4:NSF: From the Ground Up to the Air Above Coastal Dunes: How Groundwater and Evaporation Affect the Mechanism of Wind Erosion
RII Track-4:NSF:从地面到沿海沙丘上方的空气:地下水和蒸发如何影响风蚀机制
- 批准号:
2327346 - 财政年份:2024
- 资助金额:
$ 37.43万 - 项目类别:
Standard Grant
Graduating in Austerity: Do Welfare Cuts Affect the Career Path of University Students?
紧缩毕业:福利削减会影响大学生的职业道路吗?
- 批准号:
ES/Z502595/1 - 财政年份:2024
- 资助金额:
$ 37.43万 - 项目类别:
Fellowship
感性個人差指標 Affect-X の構築とビスポークAIサービスの基盤確立
建立个人敏感度指数 Affect-X 并为定制人工智能服务奠定基础
- 批准号:
23K24936 - 财政年份:2024
- 资助金额:
$ 37.43万 - 项目类别:
Grant-in-Aid for Scientific Research (B)
Insecure lives and the policy disconnect: How multiple insecurities affect Levelling Up and what joined-up policy can do to help
不安全的生活和政策脱节:多种不安全因素如何影响升级以及联合政策可以提供哪些帮助
- 批准号:
ES/Z000149/1 - 财政年份:2024
- 资助金额:
$ 37.43万 - 项目类别:
Research Grant
How does metal binding affect the function of proteins targeted by a devastating pathogen of cereal crops?
金属结合如何影响谷类作物毁灭性病原体靶向的蛋白质的功能?
- 批准号:
2901648 - 财政年份:2024
- 资助金额:
$ 37.43万 - 项目类别:
Studentship
Investigating how double-negative T cells affect anti-leukemic and GvHD-inducing activities of conventional T cells
研究双阴性 T 细胞如何影响传统 T 细胞的抗白血病和 GvHD 诱导活性
- 批准号:
488039 - 财政年份:2023
- 资助金额:
$ 37.43万 - 项目类别:
Operating Grants
New Tendencies of French Film Theory: Representation, Body, Affect
法国电影理论新动向:再现、身体、情感
- 批准号:
23K00129 - 财政年份:2023
- 资助金额:
$ 37.43万 - 项目类别:
Grant-in-Aid for Scientific Research (C)
The Protruding Void: Mystical Affect in Samuel Beckett's Prose
突出的虚空:塞缪尔·贝克特散文中的神秘影响
- 批准号:
2883985 - 财政年份:2023
- 资助金额:
$ 37.43万 - 项目类别:
Studentship