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A biomarker panel based smart mini-array system for the homecare of autoimmune kidney diseases

基于生物标记物面板的智能微型阵列系统，用于自身免疫性肾病的家庭护理

基本信息

批准号：
10555290
负责人：
Tianfu Wu
金额：
$ 43.58万
依托单位：
UNIVERSITY OF HOUSTON
依托单位国家：
美国
项目类别：
财政年份：
2019
资助国家：
美国
起止时间：
2019-04-01 至 2025-01-31
项目状态：
未结题

来源：
https://reporter.nih.gov/project-details/10555290
关键词：
ALCAM gene Affect Anti-Inflammatory Agents Antibodies Autoimmune Autoimmune Diseases Biological Assay Biological Markers Cellular Phone Chronic Disease Clinical Clinical Research Code Complex Creatinine Data Data Reporting Development Diagnosis Diagnostic Disabled Persons Disease Economic Burden Enzyme-Linked Immunosorbent Assay Equipment Female of child bearing age Flare Health Services Accessibility Healthcare Hemopexin Home Image Immunosuppressive Agents Improve Access Inpatients Kidney Kidney Diseases Longitudinal cohort Lupus Lupus Nephritis Measurement Measures Monitor Nephritis Organ Outcome Patients Personal Satisfaction Pharmaceutical Preparations Process Properdin Protein Array Proteins Reading Reagent Reporting Reproducibility Resources Sampling Self Management Sensitivity and Specificity System Systemic Lupus Erythematosus TFPI Technology Testing Time Touch sensation Transportation Urine Validation Woman Work aged aptamer biomarker panel biomarker performance calpastatin clinically actionable cohort home test improved innovation kidney biopsy mortality novel novel marker patient home care point of care point-of-care detection prototype screening self testing smartphone application socioeconomics specific biomarkers treatment research urinary

项目摘要

Project summary Systemic lupus erythematosus (SLE) is a complex autoimmune disease predominantly affecting women. Lupus nephritis (LN), is a leading cause of high mortality. Timely treatment of LN flares with anti-inflammatory and immunosuppressant drugs is critical, but flares are not currently diagnosed in a point-of-care or home setting; the gold standard for LN flare diagnosis is renal biopsy. At-home or Point-of-care (POC) detection of LN flares would improve treatment responsiveness access and facilitate SLE clinical research. We propose 3 specific aims: AIM 1: To develop multiplex quantitative Biomarker Mini-array (BMA) for urinary SLE flare markers. AIM 2: To develop a reliable, convenient Biomarker Mini-array for LN flare identification by smartphone based analysis and reporting system (SBARS). AIM 3: To evaluate the clinical performance of the BMA-SBARS tests in disease settings, using urine samples from cross- sectional and longitudinal cohorts of LN patients. The primary innovation of the proposed work lies in its development of a prototype practical POC/self-testing urine test for LN flares. The technology itself will have broad impact in self-management of chronic diseases at home, especially for aged patients.

项目总结系统性红斑狼疮(SLE)是一种复杂的自身免疫性疾病。女人。狼疮性肾炎(LN)是导致高死亡率的主要原因。LN耀斑的及时处理使用抗炎和免疫抑制药物是至关重要的，但目前还不是在护理地点或家庭环境中诊断；诊断LN耀斑的黄金标准是肾脏活组织检查。在家或护理点(POC)检测LN耀斑将改善治疗响应性获取和促进SLE临床研究。我们提出了三个具体目标：目标1：建立尿路系统性红斑狼疮斑块标志物多重定量生物标志物微阵列(BMA)。目的2：建立一种可靠、方便的LN耀斑生物标志物微阵列基于智能手机的分析报告系统(SBARS)。目的3：评估临床应用 BMA-SBARS检测在疾病环境中的性能，使用来自交叉口的尿样 LN患者的横断面和纵向队列。拟议工作的主要创新之处在于它开发了一种实用的LN耀斑POC/自检尿液测试原型。这个技术本身将对家庭慢性病的自我管理产生广泛影响，尤其是对老年患者。