A biomarker panel based smart mini-array system for the homecare of autoimmune kidney diseases

基于生物标记物面板的智能微型阵列系统，用于自身免疫性肾病的家庭护理

• 批准号: 10337193
• 负责人: Tianfu Wu
• 金额: $ 43.52万
• 依托单位: UNIVERSITY OF HOUSTON
• 依托单位国家: 美国
• 财政年份: 2019
• 资助国家: 美国
• 起止时间: 2019-04-01 至 2024-01-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10337193
• 关键词: ALCAM gene; Affect; Anti-Inflammatory Agents; Antibodies; Autoimmune; Autoimmune Diseases; Biological Assay; Biological Markers; Cellular Phone; Chronic Disease; Clinical; Clinical Research; Code; Complex; Creatinine; Data; Data Reporting; Detection; Development; Diagnosis; Diagnostic; Disabled Persons; Disease; Economic Burden; Enzyme-Linked Immunosorbent Assay; Equipment; Female of child bearing age; Flare; Gold; Health Services Accessibility; Healthcare; Hemopexin; Home; Image; Immunosuppressive Agents; Improve Access; Inpatients; Kidney; Kidney Diseases; Longitudinal cohort; Lupus; Lupus Nephritis; Measurement; Measures; Monitor; Nephritis; Organ; Outcome; Patients; Personal Satisfaction; Pharmaceutical Preparations; Process; Properdin; Protein Array; Proteins; Reading; Reagent; Reporting; Reproducibility; Resources; Sampling; Self Management; Sensitivity and Specificity; System; Systemic Lupus Erythematosus; TFPI; Technology; Testing; Time; Touch sensation; Transportation; Urine; Validation; Woman; Work; aged; aptamer; base; biomarker panel; biomarker performance; calpastatin; clinically actionable; cohort; home test; improved; innovation; kidney biopsy; mortality; novel; novel marker; point of care; prototype; screening; self testing; smartphone Application; socioeconomics; specific biomarkers; treatment research; urinary

Project summary Systemic lupus erythematosus (SLE) is a complex autoimmune disease predominantly affecting women. Lupus nephritis (LN), is a leading cause of high mortality. Timely treatment of LN flares with anti-inflammatory and immunosuppressant drugs is critical, but flares are not currently diagnosed in a point-of-care or home setting; the gold standard for LN flare diagnosis is renal biopsy. At-home or Point-of-care (POC) detection of LN flares would improve treatment responsiveness access and facilitate SLE clinical research. We propose 3 specific aims: AIM 1: To develop multiplex quantitative Biomarker Mini-array (BMA) for urinary SLE flare markers. AIM 2: To develop a reliable, convenient Biomarker Mini-array for LN flare identification by smartphone based analysis and reporting system (SBARS). AIM 3: To evaluate the clinical performance of the BMA-SBARS tests in disease settings, using urine samples from cross- sectional and longitudinal cohorts of LN patients. The primary innovation of the proposed work lies in its development of a prototype practical POC/self-testing urine test for LN flares. The technology itself will have broad impact in self-management of chronic diseases at home, especially for aged patients.

项目总结