Training in Advanced Heart Disease Research

高级心脏病研究培训

• 批准号: 10556039
• 负责人: Joshua I Goldhaber
• 金额: $ 54.02万
• 依托单位: CEDARS-SINAI MEDICAL CENTER
• 依托单位国家: 美国
• 财政年份: 2013
• 资助国家: 美国
• 起止时间: 2013-08-01 至 2028-07-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10556039
• 关键词: Heart Diseases; Research; Training

The Smidt Heart Institute (SHI) at Cedars-Sinai Medical Center (CSMC) is applying for the second competitive renewal of its postdoctoral Advanced Heart Disease Research Training Program. The objective of this program is to provide outstanding team-mentored training in either basic biomedical, translational or health services research to six postdoctoral fellows (3 per year x 2 years). The goal is to provide trainees with the necessary skills to develop independent and productive academic careers in cardiovascular science. We seek to ensure that all our trainees, be they PhDs, MDs, MD/PhDs or equivalent, develop an in-depth knowledge of the basic science underpinning clinically relevant problems in cardiovascular medicine, as well as a comprehensive understanding of rigorous study design, appropriate methodology, and expert technical execution of basic and clinical studies. This not only provides clinical investigators with the skills they need to properly test hypotheses generated at the basic science level, but also informs basic scientists about the clinical aspects of disease in order to stimulate clinically relevant state-of-the-art investigations in the laboratory. Our training program’s areas of research focus include Cardiac Biology, Arrhythmias, Vascular Biology and Atherosclerosis, Regenerative Medicine, Transplant Immunology, Cardiovascular Imaging, Women’s Health, Community Health, Implementation Science, Precision Medicine, Artificial Intelligence, Proteomics, and Genetics. The Training Program takes full advantage of the unique strengths of CSMC, the largest private teaching hospital west of the Mississippi, which has a longstanding commitment to translational research and to serving the local community. The SHI houses the largest adult heart transplant program in the world, performed an NIH-funded first-in-human trial of cardiac-derived stem cell therapy, and has attracted many NIH-funded basic and translational investigators. Some of these share joint appointments in other CSMC units, which include the Regenerative Medicine Institute, Biomedical Imaging Research Institute, Advanced Clinical Biosystems Institute and the Departments of Biomedical Sciences, Medicine, and Pathology. Trainees receive an intensive research experience in a focused area of investigation, augmented by a formal curriculum that includes both basic and clinical seminars, instruction in grant and manuscript writing, biostatistics, methodology, and ethics. Courses are provided by the Department of Biomedical Sciences, the CSMC Clinical Scholars Program, and a multi-campus NIH CTSA-supported Center for Translational Science Institute (CTSI, includes CSMC, UCLA, Harbor-UCLA, and Charles R. Drew University). The CTSI provides our trainees with privileged access to project seed funds, additional courses in clinical research design, methodology and biostatistics, UCLA degree programs in public health and clinical research, and tools for conducting the entire range of studies from bench to bedside to community. In summary, we have designed a program that provides in-depth training in critical areas of cardiovascular science within an environment that champions translational research and clinical excellence.

西达斯-西奈医疗中心（CSMC）的史密特心脏研究所（SHI）正在申请第二届竞争

项目成果

Refining Safe Contrast Limits for Preventing Acute Kidney Injury After Percutaneous Coronary Intervention.

• DOI: 10.1161/jaha.120.018890
• 发表时间: 2021-01-05
• 期刊: Journal of the American Heart Association
• 影响因子: 5.4
• 作者: Yuan N;Latif K;Botting PG;Elad Y;Bradley SM;Nuckols TK;Cheng S;Ebinger JE
• 通讯作者: Ebinger JE

Evaluating age-based eligibility thresholds for heart re-transplantation - an analysis of the united network for organ sharing database.

评估基于年龄的心脏再移植资格阈值——对器官共享数据库联合网络的分析。

• DOI: 10.1016/j.healun.2022.11.012
• 发表时间: 2023
• 期刊: The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation
• 作者: Chen,Qiudong;Malas,Jad;Chan,Joshua;Esmailian,Gabriel;Emerson,Dominic;Megna,Dominick;Catarino,Pedro;Bowdish,MichaelE;Kittleson,Michelle;Patel,Jignesh;Chikwe,Joanna;Kobashigawa,Jon;Esmailian,Fardad
• 通讯作者: Esmailian,Fardad

Allogeneic cardiospheres delivered via percutaneous transendocardial injection increase viable myocardium, decrease scar size, and attenuate cardiac dilatation in porcine ischemic cardiomyopathy.

• DOI: 10.1371/journal.pone.0113805
• 发表时间: 2014
• 期刊: PloS one
• 影响因子: 3.7
• 作者: Yee K;Malliaras K;Kanazawa H;Tseliou E;Cheng K;Luthringer DJ;Ho CS;Takayama K;Minamino N;Dawkins JF;Chowdhury S;Duong DT;Seinfeld J;Middleton RC;Dharmakumar R;Li D;Marbán L;Makkar RR;Marbán E
• 通讯作者: Marbán E

Impact of minimally invasive lung transplantation on early outcomes and analgesia use: A matched cohort study.

微创肺移植对早期结果和镇痛使用的影响：一项匹配队列研究。

• DOI: 10.1016/j.healun.2024.01.014
• 发表时间: 2024
• 期刊: The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation
• 作者: Thomas,Jason;Chen,Qiudong;Malas,Jad;Barnes,Darina;Roach,Amy;Peiris,Achille;Premananthan,Sharmini;Krishnan,Aasha;Rowe,Georgina;Gill,George;Zaffiri,Lorenzo;Chikwe,Joanna;Emerson,Dominic;Catarino,Pedro;Rampolla,Reinaldo;Megna,D
• 通讯作者: Megna,D

Heart transplantation using donation after circulatory death in the United States.

在美国，循环死亡后使用捐赠进行心脏移植。

• DOI: 10.1016/j.jtcvs.2022.05.005
• 发表时间: 2023
• 期刊: The Journal of thoracic and cardiovascular surgery
• 作者: Chen,Qiudong;Emerson,Dominic;Megna,Dominick;Osho,Asishana;Roach,Amy;Chan,Joshua;Rowe,Georgina;Gill,George;Esmailian,Fardad;Chikwe,Joanna;Egorova,Natalia;Kirklin,JamesK;Kobashigawa,Jon;Catarino,Pedro
• 通讯作者: Catarino,Pedro