Training in Advanced Heart Disease Research

高级心脏病研究培训

• 批准号: 10556039
• 负责人: Joshua I Goldhaber
• 金额: $ 54.02万
• 依托单位: CEDARS-SINAI MEDICAL CENTER
• 依托单位国家: 美国
• 财政年份: 2013
• 资助国家: 美国
• 起止时间: 2013-08-01 至 2028-07-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10556039
• 关键词: Heart Diseases; Research; Training

The Smidt Heart Institute (SHI) at Cedars-Sinai Medical Center (CSMC) is applying for the second competitive renewal of its postdoctoral Advanced Heart Disease Research Training Program. The objective of this program is to provide outstanding team-mentored training in either basic biomedical, translational or health services research to six postdoctoral fellows (3 per year x 2 years). The goal is to provide trainees with the necessary skills to develop independent and productive academic careers in cardiovascular science. We seek to ensure that all our trainees, be they PhDs, MDs, MD/PhDs or equivalent, develop an in-depth knowledge of the basic science underpinning clinically relevant problems in cardiovascular medicine, as well as a comprehensive understanding of rigorous study design, appropriate methodology, and expert technical execution of basic and clinical studies. This not only provides clinical investigators with the skills they need to properly test hypotheses generated at the basic science level, but also informs basic scientists about the clinical aspects of disease in order to stimulate clinically relevant state-of-the-art investigations in the laboratory. Our training program’s areas of research focus include Cardiac Biology, Arrhythmias, Vascular Biology and Atherosclerosis, Regenerative Medicine, Transplant Immunology, Cardiovascular Imaging, Women’s Health, Community Health, Implementation Science, Precision Medicine, Artificial Intelligence, Proteomics, and Genetics. The Training Program takes full advantage of the unique strengths of CSMC, the largest private teaching hospital west of the Mississippi, which has a longstanding commitment to translational research and to serving the local community. The SHI houses the largest adult heart transplant program in the world, performed an NIH-funded first-in-human trial of cardiac-derived stem cell therapy, and has attracted many NIH-funded basic and translational investigators. Some of these share joint appointments in other CSMC units, which include the Regenerative Medicine Institute, Biomedical Imaging Research Institute, Advanced Clinical Biosystems Institute and the Departments of Biomedical Sciences, Medicine, and Pathology. Trainees receive an intensive research experience in a focused area of investigation, augmented by a formal curriculum that includes both basic and clinical seminars, instruction in grant and manuscript writing, biostatistics, methodology, and ethics. Courses are provided by the Department of Biomedical Sciences, the CSMC Clinical Scholars Program, and a multi-campus NIH CTSA-supported Center for Translational Science Institute (CTSI, includes CSMC, UCLA, Harbor-UCLA, and Charles R. Drew University). The CTSI provides our trainees with privileged access to project seed funds, additional courses in clinical research design, methodology and biostatistics, UCLA degree programs in public health and clinical research, and tools for conducting the entire range of studies from bench to bedside to community. In summary, we have designed a program that provides in-depth training in critical areas of cardiovascular science within an environment that champions translational research and clinical excellence.

Cedars-Sinai医学中心（CSMC）的心脏研究所（SHI）正在申请第二次竞争性 更新其博士后高级心脏病研究培训计划。该计划的目标 在基础生物医学、翻译或健康服务方面提供出色的团队指导培训 为6名博士后研究员提供研究（每年3名x2年）。目标是为学员提供必要的 培养心血管科学独立和富有成效的学术生涯的技能。我们寻求确保 我们所有的学员，无论是博士，医学博士，医学博士/博士或同等学历，都要深入了解基本的 心血管医学临床相关问题的科学基础，以及一个全面的 了解严格的研究设计，适当的方法学，以及基本和 临床研究。这不仅为临床研究者提供了正确检验假设所需的技能 在基础科学水平上产生，但也告知基础科学家关于疾病的临床方面， 以刺激实验室中临床相关的最新研究。我们的培训项目 研究方向包括心脏生物学、心律失常、血管生物学和动脉粥样硬化、再生 医学，移植免疫学，心血管成像，妇女健康，社区健康， 实施科学、精准医学、人工智能、蛋白质组学和遗传学。培训 该计划充分利用了CSMC的独特优势，CSMC是美国西部最大的私立教学医院。 密西西比，它有一个长期致力于转化研究和服务当地社区。 SHI拥有世界上最大的成人心脏移植计划，进行了NIH资助的首次人体心脏移植。 心脏源性干细胞治疗的试验，并吸引了许多NIH资助的基础和转化 investigators.其中一些人在其他CSMC单位共享联合任命，其中包括再生 医学研究所、生物医学成像研究所、高级临床生物系统研究所和 生物医学科学、医学和病理学系。学员接受密集的研究 在调查的重点领域的经验，通过正式的课程，包括基础和补充， 临床研讨会，指导赠款和手稿写作，生物统计学，方法学和伦理学。课程 由生物医学科学系，CSMC临床学者计划和多校区提供 NIH CTSA支持的转化科学研究中心（CTSI，包括CSMC，UCLA，Harbor-UCLA， 查尔斯·R。德鲁大学）。CTSI为我们的学员提供获得项目种子基金的特权， 在临床研究设计，方法学和生物统计学，加州大学洛杉矶分校学位课程在公共附加课程 健康和临床研究，以及用于进行从实验台到床边的整个研究范围的工具， 社区总之，我们设计了一个计划，在关键领域提供深入的培训， 心血管科学在一个环境中，冠军转化研究和临床卓越。

项目成果

Refining Safe Contrast Limits for Preventing Acute Kidney Injury After Percutaneous Coronary Intervention.

• DOI: 10.1161/jaha.120.018890
• 发表时间: 2021-01-05
• 期刊: Journal of the American Heart Association
• 影响因子: 5.4
• 作者: Yuan N;Latif K;Botting PG;Elad Y;Bradley SM;Nuckols TK;Cheng S;Ebinger JE
• 通讯作者: Ebinger JE

Evaluating age-based eligibility thresholds for heart re-transplantation - an analysis of the united network for organ sharing database.

评估基于年龄的心脏再移植资格阈值——对器官共享数据库联合网络的分析。

• DOI: 10.1016/j.healun.2022.11.012
• 发表时间: 2023
• 期刊: The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation
• 作者: Chen,Qiudong;Malas,Jad;Chan,Joshua;Esmailian,Gabriel;Emerson,Dominic;Megna,Dominick;Catarino,Pedro;Bowdish,MichaelE;Kittleson,Michelle;Patel,Jignesh;Chikwe,Joanna;Kobashigawa,Jon;Esmailian,Fardad
• 通讯作者: Esmailian,Fardad

Allogeneic cardiospheres delivered via percutaneous transendocardial injection increase viable myocardium, decrease scar size, and attenuate cardiac dilatation in porcine ischemic cardiomyopathy.

• DOI: 10.1371/journal.pone.0113805
• 发表时间: 2014
• 期刊: PloS one
• 影响因子: 3.7
• 作者: Yee K;Malliaras K;Kanazawa H;Tseliou E;Cheng K;Luthringer DJ;Ho CS;Takayama K;Minamino N;Dawkins JF;Chowdhury S;Duong DT;Seinfeld J;Middleton RC;Dharmakumar R;Li D;Marbán L;Makkar RR;Marbán E
• 通讯作者: Marbán E

Impact of minimally invasive lung transplantation on early outcomes and analgesia use: A matched cohort study.

微创肺移植对早期结果和镇痛使用的影响：一项匹配队列研究。

• DOI: 10.1016/j.healun.2024.01.014
• 发表时间: 2024
• 期刊: The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation
• 作者: Thomas,Jason;Chen,Qiudong;Malas,Jad;Barnes,Darina;Roach,Amy;Peiris,Achille;Premananthan,Sharmini;Krishnan,Aasha;Rowe,Georgina;Gill,George;Zaffiri,Lorenzo;Chikwe,Joanna;Emerson,Dominic;Catarino,Pedro;Rampolla,Reinaldo;Megna,D
• 通讯作者: Megna,D

Heart transplantation using donation after circulatory death in the United States.

在美国，循环死亡后使用捐赠进行心脏移植。

• DOI: 10.1016/j.jtcvs.2022.05.005
• 发表时间: 2023
• 期刊: The Journal of thoracic and cardiovascular surgery
• 作者: Chen,Qiudong;Emerson,Dominic;Megna,Dominick;Osho,Asishana;Roach,Amy;Chan,Joshua;Rowe,Georgina;Gill,George;Esmailian,Fardad;Chikwe,Joanna;Egorova,Natalia;Kirklin,JamesK;Kobashigawa,Jon;Catarino,Pedro
• 通讯作者: Catarino,Pedro