Training in Advanced Heart Disease Research

高级心脏病研究培训

• 批准号: 8550586
• 负责人: Joshua I Goldhaber
• 金额: $ 19.58万
• 依托单位: CEDARS-SINAI MEDICAL CENTER
• 依托单位国家: 美国
• 财政年份: 2013
• 资助国家: 美国
• 起止时间: 2013-08-01 至 2018-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8550586
• 关键词: Heart Diseases; Research; Training

DESCRIPTION (provided by applicant): The Cedars-Sinai Heart Institute (CSHI) is applying for a new Institutional Training Grant for its Advanced Heart Disease Research Training Program. The objective of the proposed Training Program is to provide outstanding team-mentored training in basic biomedical and translational research to six postdoctoral fellows (3 per year x 2 years) in order to provide them with the necessary skills to develop independent and productive academic careers in cardiovascular science. We seek to ensure that all of our trainees, be they PhDs, MDs or MD/PhDs, develop an in-depth knowledge of the basic science underpinning clinically relevant problems in cardiovascular medicine, as well as a comprehensive understanding of rigorous study design, appropriate methodology and expert technical execution of basic and clinical studies. This not only provides clinical investigators wih the skills they need to properly test hypotheses generated at the basic science level, but also informs basic scientists about the clinical aspects of disease in order to stimulate clinically relevant state-of- the-art investigations in the laboratory. Areas of research focus at the CSHI include Cardiac Biology, Arrhythmias, Vascular Biology and Atherosclerosis, Regenerative Medicine, Transplant Immunology, Cardiovascular Imaging, Women's Health, and Genetics. The Training Program takes advantage of the unique strengths of Cedars-Sinai Medical Center (CSMC), the largest private teaching hospital west of the Mississippi, which has a longstanding commitment to translational research and to serving the local community. The CSHI was established at CSMC in 2007 and has grown rapidly. It is now houses the largest adult heart transplant program in the world, performed an NIH-funded first-in-human trial of cardiac-derived stem cell therapy, and has attracted many NIH-funded basic and translational investigators. Some of these share joint appointments in other CSMC units, which include the Regenerative Medicine Institute, Biomedical Imaging Research Institute, Medical Genetics Institute, as well as the UCLA Department of Physiology. Trainees receive an intensive research experience in a focused area of investigation, augmented by a formal curriculum that includes both basic and clinical seminars, instruction in grant and manuscript writing, public speaking, biostatistics and ethics. Several courses are provided by the CSMC Department of Biomedical Sciences, the CSMC Clinical Scholars Program, and a multi-campus NIH CTSA-supported Center for Translational Science Institute (CTSI, includes CSMC, UCLA, Harbor-UCLA, and Charles Drew University). The CTSI provides our trainees with privileged access to project seed funds, additional courses in clinical research design, and tools for conducting the entire range of studies from bench to bedside to community. In summary, we have designed a program that provides in-depth training in critical areas of cardiovascular science within an environment that champions translational research and clinical excellence. We will actively recruit outstanding candidates with diverse and underrepresented backgrounds to fill the six positions (three the first year) in this training program.

描述（由申请人提供）：雪松-西奈心脏研究所（CSHI）正在为其高级心脏病研究培训计划申请新的机构培训补助金。该培训计划的目标是为六名博士后（每年3名× 2年）提供基础生物医学和转化研究方面的优秀团队指导培训，以使他们具备在心血管科学领域发展独立和富有成效的学术生涯所需的技能。我们力求确保我们所有的学员，无论是博士、医学博士还是医学博士/博士，都能深入了解心血管医学临床相关问题的基础科学，并全面了解严格的研究设计、适当的方法和基础和临床研究的专业技术执行。这不仅为临床研究人员提供了他们需要的技能，以正确地检验在基础科学水平上产生的假设，而且还告知基础科学家有关疾病的临床方面，以便在实验室中刺激临床相关的最新研究。CSHI的研究重点包括心脏生物学、心律失常、血管生物学和动脉粥样硬化、再生医学、移植免疫学、心血管成像、妇女健康和遗传学。该培训计划利用了西达斯-西奈医疗中心（CSMC）的独特优势，该中心是密西西比河以西最大的私立教学医院，长期致力于转化研究和服务当地社区。CSHI于2007年在CSMC成立，并迅速发展。它现在是世界上最大的成人心脏移植项目的所在地，进行了美国国立卫生研究院资助的心脏干细胞治疗的首次人体试验，并吸引了许多美国国立卫生研究院资助的基础和转化研究者。其中一些人在CSMC的其他部门共同任职，包括再生医学研究所、生物医学成像研究所、医学遗传学研究所以及加州大学洛杉矶分校生理学系。受训者在一个重点调查领域获得密集的研究经验，并通过正式课程得到加强，包括基础和临床研讨会、资助和手稿写作指导、公开演讲、生物统计学和伦理学。一些课程由CSMC生物医学科学系，CSMC临床学者计划和NIH ctsa支持的多校区转化科学研究所中心（CTSI，包括CSMC，加州大学洛杉矶分校，加州大学洛杉矶分校海港分校和查尔斯德鲁大学）提供。CTSI为我们的学员提供了获得项目种子基金的特权，额外的临床研究设计课程，以及进行从实验室到床边到社区的整个研究范围的工具。总之，我们设计了一个项目，在支持转化研究和临床卓越的环境中，提供心血管科学关键领域的深入培训。我们将积极招募具有多元化和代表性不足背景的优秀候选人来填补该培训计划中的六个职位（第一年三个）。