Training in Advanced Heart Disease Research

高级心脏病研究培训

• 批准号: 10250485
• 负责人: Joshua I Goldhaber
• 金额: $ 37.06万
• 依托单位: CEDARS-SINAI MEDICAL CENTER
• 依托单位国家: 美国
• 财政年份: 2013
• 资助国家: 美国
• 起止时间: 2013-08-01 至 2023-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10250485
• 关键词: Heart Diseases; Research; Training

The Cedars-Sinai Heart Institute (CSHI) is applying for the first competitive renewal of its Advanced Heart Disease Research Training Program. The objective of this Institutional Training Program is to build on our initial success (66% success rate for K awards in our first graduating class) to provide outstanding team-mentored training in basic biomedical and translational research to six postdoctoral fellows (3 per year x 2 years). The goal is to provide postdoctoral fellows with the necessary skills to develop independent and productive academic careers in cardiovascular science. We seek to ensure that all our trainees, be they PhDs, MDs, MD/PhDs or equivalent, develop an in-depth knowledge of the basic science underpinning clinically relevant problems in cardiovascular medicine, as well as a comprehensive understanding of rigorous study design, appropriate methodology and expert technical execution of basic and clinical studies. This not only provides clinical investigators with the skills they need to properly test hypotheses generated at the basic science level, but also informs basic scientists about the clinical aspects of disease in order to stimulate clinically relevant state-of-the- art investigations in the laboratory. Our training program's areas of research focus include Cardiac Biology, Arrhythmias, Vascular Biology and Atherosclerosis, Regenerative Medicine, Transplant Immunology, Cardiovascular Imaging, Women's Health, Community Health, Implementation Science, Precision Medicine and Genetics. The Training Program takes full advantage of the unique strengths of Cedars-Sinai Medical Center (CSMC), the largest private teaching hospital west of the Mississippi, which has a longstanding commitment to translational research and to serving the local community. The CSHI houses the largest adult heart transplant program in the world, performed an NIH-funded first-in-human trial of cardiac-derived stem cell therapy, and has attracted many NIH-funded basic and translational investigators. Some of these share joint appointments in other CSMC units, which include the Regenerative Medicine Institute, Biomedical Imaging Research Institute, and the Departments of Biomedical Sciences, Medicine, and Pathology. Trainees receive an intensive research experience in a focused area of investigation, augmented by a formal curriculum that includes both basic and clinical seminars, instruction in grant and manuscript writing, public speaking, biostatistics and ethics. Several courses are provided by the Department of Biomedical Sciences, the CSMC Clinical Scholars Program, and a multi-campus NIH CTSA-supported Center for Translational Science Institute (CTSI, includes CSMC, UCLA, Harbor-UCLA, and Charles Drew University). The CTSI provides our trainees with privileged access to project seed funds, additional courses in clinical research design, and tools for conducting the entire range of studies from bench to bedside to community. In summary, we have designed a program that provides in-depth training in critical areas of cardiovascular science within an environment that champions translational research and clinical excellence.

Cedars-Sinai Heart Institute（CSHI）正在申请其先进心脏的第一个竞争性更新 疾病研究培训计划。该机构培训计划的目的是建立我们的最初 成功（在我们的第一届毕业班级中，K奖的成功率为66％）提供出色的团队服务 基本生物医学和转化研究的培训对六个博士后研究员（每年3年2年）进行培训。目标 是为博士后研究员提供开发独立和生产力的必要技能 心血管科学的职业。我们试图确保所有学员，无论是博士学位，MD，MD/PHD还是 等效，发展对基础科学的深入了解，这是基础上的临床相关问题 心血管医学以及对严格研究设计的全面理解，适当 基础和临床研究的方法和专家技术执行。这不仅提供临床 调查人员的技能需要正确测试在基础科学层面产生的假设，也需要 告知基础科学家疾病的临床方面，以刺激临床相关的最新 实验室的艺术调查。我们的培训计划的研究重点包括心脏生物学， 心律不齐，血管生物学和动脉粥样硬化，再生医学，移植免疫学， 心血管成像，妇女健康，社区健康，实施科学，精密医学和 遗传学。培训计划充分利用了Cedars-Sinai医疗中心的独特优势 （CSMC）是密西西比州以西最大的私立教学医院，该医院长期致力于 翻译研究并为当地社区服务。 CSHI是最大的成人心脏移植 世界上的计划，对心脏衍生的干细胞疗法进行了NIH资助的首次人类试验，并具有 吸引了许多由NIH资助的基本和翻译调查员。其中一些在其他共同任命中共同任命 CSMC单元，包括再生医学研究所，生物医学成像研究所和 生物医学，医学和病理学系。学员接受了深入的研究 在重点调查领域的经验，由包括基本和包括基本和 临床研讨会，赠款和手稿写作的指导，公开演讲，生物统计学和道德规范。一些 课程由生物医学科学系，CSMC临床学者计划和A提供 多校区NIH CTSA支持转化科学研究所中心（CTSI，包括CSMC，UCLA，UCLA， 港口 - 乌奇拉和查尔斯·德鲁大学）。 CTSI为我们的受训者提供了特权访问项目 种子资金，临床研究设计的其他课程以及用于进行整个研究范围的工具 从长凳到床边再到社区。总而言之，我们设计了一个提供深入培训的程序 在倡导转化研究和的环境中，心血管科学的关键领域 临床卓越。