Training in Advanced Heart Disease Research

高级心脏病研究培训

• 批准号: 10000201
• 负责人: Joshua I Goldhaber
• 金额: $ 49.8万
• 依托单位: CEDARS-SINAI MEDICAL CENTER
• 依托单位国家: 美国
• 财政年份: 2013
• 资助国家: 美国
• 起止时间: 2013-08-01 至 2023-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10000201
• 关键词: Heart Diseases; Research; Training

The Cedars-Sinai Heart Institute (CSHI) is applying for the first competitive renewal of its Advanced Heart Disease Research Training Program. The objective of this Institutional Training Program is to build on our initial success (66% success rate for K awards in our first graduating class) to provide outstanding team-mentored training in basic biomedical and translational research to six postdoctoral fellows (3 per year x 2 years). The goal is to provide postdoctoral fellows with the necessary skills to develop independent and productive academic careers in cardiovascular science. We seek to ensure that all our trainees, be they PhDs, MDs, MD/PhDs or equivalent, develop an in-depth knowledge of the basic science underpinning clinically relevant problems in cardiovascular medicine, as well as a comprehensive understanding of rigorous study design, appropriate methodology and expert technical execution of basic and clinical studies. This not only provides clinical investigators with the skills they need to properly test hypotheses generated at the basic science level, but also informs basic scientists about the clinical aspects of disease in order to stimulate clinically relevant state-of-the- art investigations in the laboratory. Our training program's areas of research focus include Cardiac Biology, Arrhythmias, Vascular Biology and Atherosclerosis, Regenerative Medicine, Transplant Immunology, Cardiovascular Imaging, Women's Health, Community Health, Implementation Science, Precision Medicine and Genetics. The Training Program takes full advantage of the unique strengths of Cedars-Sinai Medical Center (CSMC), the largest private teaching hospital west of the Mississippi, which has a longstanding commitment to translational research and to serving the local community. The CSHI houses the largest adult heart transplant program in the world, performed an NIH-funded first-in-human trial of cardiac-derived stem cell therapy, and has attracted many NIH-funded basic and translational investigators. Some of these share joint appointments in other CSMC units, which include the Regenerative Medicine Institute, Biomedical Imaging Research Institute, and the Departments of Biomedical Sciences, Medicine, and Pathology. Trainees receive an intensive research experience in a focused area of investigation, augmented by a formal curriculum that includes both basic and clinical seminars, instruction in grant and manuscript writing, public speaking, biostatistics and ethics. Several courses are provided by the Department of Biomedical Sciences, the CSMC Clinical Scholars Program, and a multi-campus NIH CTSA-supported Center for Translational Science Institute (CTSI, includes CSMC, UCLA, Harbor-UCLA, and Charles Drew University). The CTSI provides our trainees with privileged access to project seed funds, additional courses in clinical research design, and tools for conducting the entire range of studies from bench to bedside to community. In summary, we have designed a program that provides in-depth training in critical areas of cardiovascular science within an environment that champions translational research and clinical excellence.

锡达斯-西奈心脏研究所(CSHI)正在申请第一次竞争更新其高级心脏 疾病研究培训计划。该机构培训计划的目标是在我们最初的基础上 成功(我们第一届毕业班获得K奖的成功率为66%)提供优秀的团队指导 对6名博士后研究员进行基础生物医学和翻译研究培训(每年3名×2年)。目标是 是为博士后研究员提供必要的技能，以发展独立和多产的学术 心血管科学方面的职业。我们努力确保我们所有的实习生，无论是博士、医学博士、医学博士或博士 相当于，发展对支持临床相关问题的基础科学的深入知识 心血管医学，以及全面了解严谨的研究设计，适当 基础和临床研究的方法论和专家技术执行。这不仅为临床提供了 研究人员拥有他们需要的技能来正确测试在基础科学水平上产生的假说，但也 向基础科学家通报疾病的临床方面，以刺激临床相关的最新状况 实验室里的艺术调查。我们培训计划的研究重点领域包括心脏生物学， 心律失常，血管生物学和动脉粥样硬化，再生医学，移植免疫学， 心血管成像、妇女健康、社区健康、实施科学、精准医学和 遗传学。培训计划充分利用锡达斯-西奈医疗中心的独特优势 密西西比河以西最大的私立教学医院(CSMC)，该医院长期致力于 翻译研究和为当地社区服务。CSHI拥有最大的成人心脏移植 计划，进行了由美国国立卫生研究院资助的心脏干细胞治疗的首个人体试验，并已经 吸引了许多由NIH资助的基础和翻译研究人员。其中一些人在另一些人中共享联合任命 CSMC单位，包括再生医学研究所、生物医学成像研究所和 生物医学科学系、医学系和病理学系。学员们接受了深入的研究 在重点调查领域的经验，加上正规课程，包括基础和 临床研讨会、补助金和手稿写作指导、公共演讲、生物统计学和伦理学。几个 课程由生物医学科学系、CSMC临床学者计划和一个 多校区NIH CTSA支持的翻译科学研究所中心(CTSI，包括CSMC、UCLA、 港湾-加州大学洛杉矶分校和查尔斯·德鲁大学)。CTSI为我们的实习生提供访问项目的特权 种子基金，临床研究设计的附加课程，以及进行整个研究范围的工具 从长凳到床边再到社区。总而言之，我们设计了一个提供深入培训的计划 在心血管科学的关键领域，在支持转化性研究和 临床表现卓越。