Training in Advanced Heart Disease Research

高级心脏病研究培训

• 批准号: 10000201
• 负责人: Joshua I Goldhaber
• 金额: $ 49.8万
• 依托单位: CEDARS-SINAI MEDICAL CENTER
• 依托单位国家: 美国
• 财政年份: 2013
• 资助国家: 美国
• 起止时间: 2013-08-01 至 2023-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10000201
• 关键词: Heart Diseases; Research; Training

The Cedars-Sinai Heart Institute (CSHI) is applying for the first competitive renewal of its Advanced Heart Disease Research Training Program. The objective of this Institutional Training Program is to build on our initial success (66% success rate for K awards in our first graduating class) to provide outstanding team-mentored training in basic biomedical and translational research to six postdoctoral fellows (3 per year x 2 years). The goal is to provide postdoctoral fellows with the necessary skills to develop independent and productive academic careers in cardiovascular science. We seek to ensure that all our trainees, be they PhDs, MDs, MD/PhDs or equivalent, develop an in-depth knowledge of the basic science underpinning clinically relevant problems in cardiovascular medicine, as well as a comprehensive understanding of rigorous study design, appropriate methodology and expert technical execution of basic and clinical studies. This not only provides clinical investigators with the skills they need to properly test hypotheses generated at the basic science level, but also informs basic scientists about the clinical aspects of disease in order to stimulate clinically relevant state-of-the- art investigations in the laboratory. Our training program's areas of research focus include Cardiac Biology, Arrhythmias, Vascular Biology and Atherosclerosis, Regenerative Medicine, Transplant Immunology, Cardiovascular Imaging, Women's Health, Community Health, Implementation Science, Precision Medicine and Genetics. The Training Program takes full advantage of the unique strengths of Cedars-Sinai Medical Center (CSMC), the largest private teaching hospital west of the Mississippi, which has a longstanding commitment to translational research and to serving the local community. The CSHI houses the largest adult heart transplant program in the world, performed an NIH-funded first-in-human trial of cardiac-derived stem cell therapy, and has attracted many NIH-funded basic and translational investigators. Some of these share joint appointments in other CSMC units, which include the Regenerative Medicine Institute, Biomedical Imaging Research Institute, and the Departments of Biomedical Sciences, Medicine, and Pathology. Trainees receive an intensive research experience in a focused area of investigation, augmented by a formal curriculum that includes both basic and clinical seminars, instruction in grant and manuscript writing, public speaking, biostatistics and ethics. Several courses are provided by the Department of Biomedical Sciences, the CSMC Clinical Scholars Program, and a multi-campus NIH CTSA-supported Center for Translational Science Institute (CTSI, includes CSMC, UCLA, Harbor-UCLA, and Charles Drew University). The CTSI provides our trainees with privileged access to project seed funds, additional courses in clinical research design, and tools for conducting the entire range of studies from bench to bedside to community. In summary, we have designed a program that provides in-depth training in critical areas of cardiovascular science within an environment that champions translational research and clinical excellence.

Cedars-Sinai心脏研究所（CSHI）正在申请其高级心脏的首次竞争性更新 疾病研究培训计划。该机构培训计划的目标是建立在我们最初的 成功（66%的成功率K奖在我们的第一届毕业班），以提供优秀的团队指导 为6名博士后研究员提供基础生物医学和转化研究培训（每年3名x2年）。目标 为博士后研究员提供必要的技能，以发展独立和富有成效的学术 心血管科学的职业。我们力求确保我们所有的学员，无论是博士，医学博士，医学博士/博士或 等同，发展基础科学的深入知识，支持临床相关问题， 心血管医学，以及严格的研究设计的全面理解，适当的 基础和临床研究的方法学和专家技术执行。这不仅提供了临床 调查人员具有适当测试基础科学水平产生的假设所需的技能，但也 告知基础科学家关于疾病的临床方面，以刺激临床相关的状态， 实验室里的艺术研究我们的培训计划的研究重点领域包括心脏生物学， 心律失常，血管生物学和动脉粥样硬化，再生医学，移植免疫学， 心血管成像，妇女健康，社区健康，实施科学，精准医学和 遗传学培训计划充分利用雪松西奈医疗中心的独特优势 （CSMC），密西西比以西最大的私立教学医院，长期致力于 翻译研究和服务当地社区。CSHI容纳了最大的成人心脏移植手术 该计划在世界上，进行了美国国立卫生研究院资助的心脏衍生干细胞治疗的首次人体试验，并已 吸引了许多NIH资助的基础和翻译研究人员。其中一些人在其他地方共同任命 CSMC单位，其中包括再生医学研究所，生物医学成像研究所， 生物医学科学、医学和病理学系。学员接受密集的研究 在调查的重点领域的经验，通过正式的课程，包括基础和补充， 临床研讨会，指导赠款和手稿写作，公开演讲，生物统计学和伦理学。几 课程由生物医学科学系，CSMC临床学者计划和 多校区NIH CTSA支持的转化科学研究所中心（CTSI，包括CSMC，UCLA， Harbor-UCLA和Charles Drew University）。CTSI为我们的学员提供进入项目的特权 种子基金，临床研究设计的额外课程，以及进行整个研究范围的工具 从长凳到床边再到社区总之，我们设计了一个项目， 在支持转化研究的环境中， 临床卓越