California National Primate Research Center

总体：加州州灵长类动物研究中心 摘要 位于加州大学戴维斯分校的加州国家灵长类动物研究中心（CNPRC）， 要求资金在下一个五年期（2023年5月1日）延长基本运营补助金#P51-OD 011107 2028年4月30日）。目前，在第60年的运作，CNPRC提供了一系列NIH支持的 全国范围内的调查人员和行业合作伙伴。从成立到本年度，CNPRC一直 通过提供高质量的动物、设施、工具和服务，高度响应研究界的要求 由核心科学家的知识基础设施驱动，为我们的使命服务：“改善人类健康， 健康和生活质量，通过特殊的非人类灵长类动物研究计划的支持”。的 申请的补充资金符合以下具体目标：（1）进行最先进的研究， 科学上有助于理解和治疗人类疾病的非人类灵长类动物模型 （2）为研究人员提供卓越的非人灵长类专业知识和服务， 地方，地区和国家层面，以推进NIH支持的卓越研究，（3）指导和培训下一个 产生具有非人灵长类专业知识的翻译研究人员，并向公众通报 非人灵长类动物模型的重要性和翻译能力，以及（4）确保最高标准的 负责任地进行研究和动物护理。我们将继续强调团队科学， 整个生命周期的人类健康问题，目标是超越传统的跨学科努力， 真正解决研究问题。请求为行政事务提供支助 （行政和业务处、主任办公室、信息技术处）、改建和 翻修（设施改善），菌落管理股（解剖和临床病理学服务， 动物护理和研究服务，生物行为评估，遗传学管理服务 老龄群体研究所、人口与行为健康服务和灵长类医学服务），服务 核心（流式细胞术、吸入暴露、多模式成像、灵长类动物试验实验室），科学 研究单位（呼吸系统疾病，传染病，神经科学和行为， 生殖科学和再生医学）、外联/公共信息办公室和试点研究 程序.我们致力于开发和提供广泛的研究机会， 使用非人类灵长类动物模型来改善人类健康。加州大学戴维斯分校的机构承诺， CNPRC是杰出的，并将继续促进我们在将非人灵长类动物研究纳入 转化生物医学研究的下一个时代。

OVERALL: CALIFORNIA NATIONAL PRIMATE RESEARCH CENTER ABSTRACT The California National Primate Research Center (CNPRC), located at the University of California, Davis, requests funds to renew the base operating grant #P51-OD011107 for the next five-year period (May 1, 2023 through April 30, 2028). Currently in the 60th year of operation, the CNPRC serves a range of NIH-supported investigators and industry partners nationwide. From inception through the current year, the CNPRC has been highly responsive to the research community by providing high quality animals, facilities, tools, and services driven by the intellectual infrastructure of the Core Scientists in the service of our Mission: “To improve human health and quality of life through support of exceptional nonhuman primate research programs”. The supplemental funds requested fits within the following Specific Aims: (1) Conduct state-of-the-art research and scientifically contribute to the understanding and treatment of human disease with nonhuman primate models across the life span, (2) Provide exceptional nonhuman primate expertise and services to investigators at the local, regional, and national levels to advance NIH-supported research excellence, (3) Mentor and train the next generation of translational investigators with nonhuman primate expertise and inform the public regarding the importance and translational power of the nonhuman primate model, and (4) Ensure the highest standards of responsible conduct of research and animal care. We will continue to emphasize team science aimed at major human health problems across the lifespan, with the goal of moving beyond traditional interdisciplinary efforts to true convergence on the research problems being addressed. Support is requested for Administrative Services (Administration and Operations Services, Director’s Office, Information Technology Services), Alterations and Renovations (Facilities Improvement), Colony Management Unit (Anatomic and Clinical Pathology Services, Animal Care and Research Services, BioBehavioral Assessment, Genetics Management Services National Institute on Aging Colony, Population and Behavioral Health Services, and Primate Medicine Services), Service Cores (Flow Cytometry, Inhalation Exposure, Multimodal Imaging, Primate Assay Laboratory), Scientific Research Units (Cardiorespiratory Diseases, Infectious Diseases, Neuroscience and Behavior, and Reproductive Sciences and Regenerative Medicine), Outreach/Public Information Office, and the Pilot Research Program. We are committed to developing and providing a wide range of research opportunities that maximize use of the nonhuman primate model to improve human health. The institutional commitment from UC Davis to the CNPRC is outstanding and will continue to facilitate our role in moving nonhuman primate research into the next era of translational biomedical research.