Reading Network Functional Pathways and How They Account for Alexic Variation

阅读网络功能通路及其如何解释亚历克斯变异

• 批准号: 10556417
• 负责人: Joseph Leigh Posner
• 金额: $ 5.27万
• 依托单位: GEORGETOWN UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2020
• 资助国家: 美国
• 起止时间: 2020-02-01 至 2024-01-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10556417
• 关键词: Alexia; Area; Behavior; Behavioral; Brain; Case Series; Classification; Cognitive; Communities; Complex; Consensus; Data; Development; Diagnosis; Experimental Designs; Frequencies; Frontal gyrus; Functional Magnetic Resonance Imaging; Functional disorder; Fusiform gyrus; Goals; Human; Impairment; Individual; Knowledge; Language; Learning; Left; Lesion; Life; Link; Literature; Location; Maps; Medical; Methods; Modeling; Neural Pathways; Neurobiology; Neurons; Neurophysiology - biologic function; Older Population; Orthography; Participant; Pathway interactions; Pattern; Persons; Play; Process; Psychophysiology; Pure Alexia; Quality of life; Reader; Reading; Research; Residual state; Role; Route; Running; Semantics; Societies; Specific qualifier value; Stimulus; Stroke; Surface; Survivors; System; Testing; Training; Trauma; Variant; Work; Writing; functional MRI scan; improved; individual variation; insight; interest; lexical; neural; neural network; novel; phonology; post stroke; reading ability; reading difficulties; semantic processing; skills; spelling; stroke survivor; therapy development; visual process

PROJECT SUMMARY/ABSTRACT Reading is an important development in human brain function, and it is an integral part of how we interact with other people. The impairment or loss of reading (alexia) due to a stroke can be devastating, yet an adequate understanding of how the brain processes reading functions is still lacking. From what is currently known, cognitive models of reading describe how pathways between orthographic, phonologic and semantic processing contribute to successful reading. And features of words, such as concreteness, regularity, and frequency, play an important role in identifying these pathways. Reading behaviors have also been related to specific brain areas. However, there is little literature that relates the proposed cognitive routes to neural networks. This proposal aims to connect these two fields by examining how the cognitive components of reading relate to the neurobiological processes that perform them (Aim 1). Furthermore, when the reading system breaks down, the precise mechanisms that contribute to residual reading abilities are not well specified. Deficits are usually defined by the words that cannot be read, or by the location of the damage done by a stroke or other trauma. This proposal aims to determine the role that the remaining function of the neural reading network plays in defining deficient reading behavior (Aim 2). In the proposed study, participants will undergo reading-task related fMRI scans, analyzed by functional connectivity (FC) and psychophysiological interaction (PPI) analyses, so that their reading-related connectivity can be assessed. Functional localizer tasks will be used to identify areas in the brain that govern cognitive reading components. A general reading task, with feature-controlled words, will be used for a reading-related FC analysis between those brain areas to identify reading pathways. To identify reading-related neural pathways, FC analyses will first evaluate the correlation between the activity of the identified areas; then PPI analyses will evaluate the correlation between FC changes and reading words with features that utilize specific cognitive pathways. These methods will be used to test the hypotheses that: a typically reading, older population will show reading-related FC between the areas canonically associated with reading processing (Aim 1a), and reading words that have high vs. low values of specific word features will produce differing effects in connections that reflect phonologic and semantic pathways (Aim 1b). The FC maps of pairs of participants whose lesions have significant overlap but who have different reading profiles will be compared. This will test the hypothesis that functional networks will explain variance in behavioral deficits (Aim 2). The results of this study should provide new insights into the fundamental questions of how cognitive reading routes relate to the reading network pathways in the brain, and how the surviving neural network contributes to residual reading post-stroke, which can be applied to the development of novel treatments for alexia.

项目总结/摘要 阅读是人类大脑功能的重要发展，也是我们如何互动的一个组成部分 和其他人在一起由于中风导致的阅读的损伤或丧失（失读症）可能是毁灭性的，然而， 对大脑如何处理阅读功能的理解仍然缺乏。从目前已知的情况来看， 阅读的认知模型描述了如何在拼写，语音和语义处理之间的途径 有助于成功的阅读。词语的特征，如具体性、规律性和频率， 在识别这些途径中发挥重要作用。阅读行为也与特定的大脑区域有关。 然而，很少有文献将所提出的认知路线与神经网络联系起来。这项建议 旨在通过研究阅读的认知成分如何与 执行它们的神经生物学过程（目的1）。此外，当阅读系统发生故障时， 对残余阅读能力有贡献的精确机制还没有很好地说明。赤字通常被定义为 无法阅读的文字，或者中风或其他创伤造成的损伤的位置。这 一项提案旨在确定神经阅读网络的其余功能在定义 缺乏阅读行为（目标2）。 在这项拟议中的研究中，参与者将接受与阅读任务相关的功能磁共振成像扫描， 连接（FC）和心理生理互动（PPI）的分析，使他们的阅读相关的连接 可以评估。功能定位任务将用于识别大脑中控制认知的区域 阅读组件。一个一般的阅读任务，与功能控制的话，将用于阅读相关的FC 分析这些大脑区域来识别阅读路径。为了识别阅读相关的神经通路， FC分析将首先评估已确定领域活动之间的相关性;然后PPI分析将 评估FC变化与阅读具有特定认知功能的单词之间的相关性 途径。这些方法将用于检验以下假设：一个典型的阅读，老年人群将显示 在与阅读处理（目标1a）规范关联的区域之间的阅读相关FC，以及阅读 具有高与低特定词特征值的词将在连接中产生不同的效果， 反映语音和语义路径（目标1b）。其病变具有以下特征的成对参与者的FC图： 将比较显著重叠但具有不同阅读简档的人。这将检验假设， 功能网络将解释行为缺陷的差异（目标2）。 这项研究的结果应该为认知阅读如何影响阅读的基本问题提供新的见解 路径与大脑中的阅读网络路径有关，以及幸存的神经网络如何有助于 中风后的残余阅读，这可以应用于失读症的新治疗的发展。