Mechanism of touch sensitivity in rapidly-adapting mechanosensory corpuscles

快速适应机械感觉小体的触觉敏感性机制

• 批准号: 10557111
• 负责人: Sviatoslav Bagriantsev
• 金额: $ 46.19万
• 依托单位: YALE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2016
• 资助国家: 美国
• 起止时间: 2016-12-01 至 2027-01-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10557111
• 关键词: Action Potentials; Agreement; Bioinformatics; Cells; Data; Detection; Development; Ducks; Electrophysiology (science); Elements; Embryo; Environment; Generations; Glean; Histology; Human; Individual; Ion Channel; Ion Channel Gating; Mammals; Mechanical Stimulation; Mechanics; Mechanoreceptors; Mediating; Meissners Corpuscle; Methods; Modeling; Molecular; Morphology; Neurons; Organ; Organism; Pacinian Corpuscles; Pain; Pathologic; Perception; Pharmacology; Physiological; Physiological Processes; Physiology; Piezo 2 ion channel; Play; Population; Process; Role; Shapes; Skin; Specialist; Structure; Tactile; Temperature; Testing; Touch sensation; Vertebrates; biophysical analysis; density; experience; experimental study; insight; knock-down; mechanical force; mechanical properties; mechanical stimulus; mechanotransduction; nervous system disorder; object recognition; optogenetics; parent grant; pharmacologic; pleasure; pressure; response; sensor; tool; vibration; voltage

The ability to sense the world though physical contact is essential for all living organisms. In vertebrates, transient touch and vibration are detected by Pacinian corpuscles, but the mechanism of their function is poorly understood. Pacinian corpuscles are innervated by rapidly-adapting mechanoreceptor afferents, which detect touch due to expression of mechanically activated ion channels. The mechanoreceptor is surrounded by inner core cells, which are thought to provide auxiliary non-sensory support for the mechanoreceptor. Here, we will functionally test the hypothesis that inner core cells of Pacinian corpuscles are active touch sensors. We seek to reveal the molecular mechanism of touch sensitivity and touch-evoked excitability in inner core cells, and determine the effect of inner core cell activation on mechanoreceptor function. To do this, we will use bill skin of tactile specialist ducks, which contains a high density of Pacinian corpuscles accessible for electrophysiological manipulations. Because Pacinian corpuscles are present in the skin or internal organs of most vertebrates, including all mammals, our results will further our understanding of general molecular and cellular mechanisms of touch detection.

通过身体接触来感知世界的能力对所有生物来说都是必不可少的。在脊椎动物中是短暂的