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Mechanism of Meissner corpuscle function

迈斯纳小体功能机制

基本信息

批准号：
10597159
负责人：
Sviatoslav Bagriantsev
金额：
$ 48.95万
依托单位：
YALE UNIVERSITY
依托单位国家：
美国
项目类别：
财政年份：
2022
资助国家：
美国
起止时间：
2022-04-01 至 2027-03-31
项目状态：
未结题

来源：
https://reporter.nih.gov/project-details/10597159
关键词：
3-Dimensional Action Potentials Affect Afferent Neurons Biophysics Cells Communication Data Dense Core Vesicle Detection Development Ducks Electrophysiology (science)Elements Embryo Environment Exocytosis Food Generations Goals Histologic Histology Human Hypersensitivity Image Individual Ion Channel Ion Channel Gating Knowledge Life Light Mammals Mechanics Mechanoreceptors Mediating Meissners Corpuscle Modeling Molecular Morphology Mus Neurons Organ Pain Pharmacology Physiological Physiology Piezo 2 ion channel Play Population Process Role SNAP receptor Sensory Shapes Skin Social Behavior Social Development Somatosensory Disorders Specialist Stimulus Structure Tactile Testing Touch sensation Vertebrates density detector electron tomography experience experimental study insight knock-down mechanical signal mechanical stimulus neurophysiology optogenetics pharmacologic pleasure presynaptic reconstruction response somatosensory tool transcriptome

项目摘要

Somatosensation is essential for everyday life. Many vertebrates, including humans, use the sense of touch to navigate in the environment, manipulate tools and objects, find food and perform various mechanical tasks. Key to this ability are somatosensory corpuscles located in the skin. In this proposal, we focus on Meissner corpuscles, which are essential for performing fine tactile tasks due to their ability to detect transient mechanical stimuli. Despite their importance for somatosensation, the mechanism of Meissner corpuscle function is unknown. Meissner corpuscles are located in the skin of many vertebrates, and consist of lamellar cells in contact with a neuronal mechanoreceptor. The mechanoreceptor is thought to be the key sensory element within the corpuscle, whereas the function of lamellar cells is unknown. In this proposal, we will functionally test the hypothesis that Meissner lamellar cells are active detectors of touch. To do this, we will use bill skin of tactile specialist ducks, which contains a high density of Meissner corpuscles accessible for experimental manipulations. We will investigate the molecular mechanism of touch sensitivity in Meissner lamellar cells, study their interaction with neuronal mechanoreceptor, and investigate their role in somatosensory physiology. We will employ an integrative approach, including neurophysiology, biophysics and imaging. Results from this basic scientific proposal will provide mechanistic insights into the process of somatosensation in vertebrate skin.

体感在日常生活中是必不可少的。许多脊椎动物，包括人类，使用触觉来在环境中导航，操纵工具和物体，寻找食物，执行各种机械任务。钥匙对这种能力有作用的是位于皮肤中的体感小体。在这份提案中，我们重点关注迈斯纳小体，这对于执行精细的触觉任务是必不可少的，因为它们能够检测到瞬时机械刺激物。尽管它们对躯体感觉很重要，但迈斯纳小体功能的机制是未知。触觉小体存在于许多脊椎动物的皮肤中，由接触的板层细胞组成。有一个神经性机械感受器。机械感受器被认为是而板层细胞的功能尚不清楚。在本提案中，我们将从功能上测试假设迈斯纳板层细胞是触摸的活跃探测器。为此，我们将使用触觉的比尔皮肤专业鸭子，其中包含高密度的迈斯纳小体，可供实验使用操纵。我们将研究迈斯纳板层细胞触觉敏感的分子机制它们与神经元力感受器的相互作用，并研究它们在体感生理学中的作用。我们会采用综合方法，包括神经生理学、生物物理学和成像。从这个基础上得到的结果科学提案将为脊椎动物皮肤的体感过程提供机械学上的见解。