Mechanism of Meissner corpuscle function

迈斯纳小体功能机制

基本信息

  • 批准号:
    10597159
  • 负责人:
  • 金额:
    $ 48.95万
  • 依托单位:
  • 依托单位国家:
    美国
  • 项目类别:
  • 财政年份:
    2022
  • 资助国家:
    美国
  • 起止时间:
    2022-04-01 至 2027-03-31
  • 项目状态:
    未结题

项目摘要

Somatosensation is essential for everyday life. Many vertebrates, including humans, use the sense of touch to navigate in the environment, manipulate tools and objects, find food and perform various mechanical tasks. Key to this ability are somatosensory corpuscles located in the skin. In this proposal, we focus on Meissner corpuscles, which are essential for performing fine tactile tasks due to their ability to detect transient mechanical stimuli. Despite their importance for somatosensation, the mechanism of Meissner corpuscle function is unknown. Meissner corpuscles are located in the skin of many vertebrates, and consist of lamellar cells in contact with a neuronal mechanoreceptor. The mechanoreceptor is thought to be the key sensory element within the corpuscle, whereas the function of lamellar cells is unknown. In this proposal, we will functionally test the hypothesis that Meissner lamellar cells are active detectors of touch. To do this, we will use bill skin of tactile specialist ducks, which contains a high density of Meissner corpuscles accessible for experimental manipulations. We will investigate the molecular mechanism of touch sensitivity in Meissner lamellar cells, study their interaction with neuronal mechanoreceptor, and investigate their role in somatosensory physiology. We will employ an integrative approach, including neurophysiology, biophysics and imaging. Results from this basic scientific proposal will provide mechanistic insights into the process of somatosensation in vertebrate skin.
体感在日常生活中是必不可少的。许多脊椎动物,包括人类,使用触觉来 在环境中导航,操纵工具和物体,寻找食物,执行各种机械任务。钥匙 对这种能力有作用的是位于皮肤中的体感小体。在这份提案中,我们重点关注迈斯纳 小体,这对于执行精细的触觉任务是必不可少的,因为它们能够检测到瞬时机械 刺激物。尽管它们对躯体感觉很重要,但迈斯纳小体功能的机制是 未知。触觉小体存在于许多脊椎动物的皮肤中,由接触的板层细胞组成。 有一个神经性机械感受器。机械感受器被认为是 而板层细胞的功能尚不清楚。在本提案中,我们将从功能上测试 假设迈斯纳板层细胞是触摸的活跃探测器。为此,我们将使用触觉的比尔皮肤 专业鸭子,其中包含高密度的迈斯纳小体,可供实验使用 操纵。我们将研究迈斯纳板层细胞触觉敏感的分子机制 它们与神经元力感受器的相互作用,并研究它们在体感生理学中的作用。我们会 采用综合方法,包括神经生理学、生物物理学和成像。从这个基础上得到的结果 科学提案将为脊椎动物皮肤的体感过程提供机械学上的见解。

项目成果

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Sviatoslav Bagriantsev其他文献

Sviatoslav Bagriantsev的其他文献

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{{ truncateString('Sviatoslav Bagriantsev', 18)}}的其他基金

Mechanism of Meissner corpuscle function
迈斯纳小体功能机制
  • 批准号:
    10416135
  • 财政年份:
    2022
  • 资助金额:
    $ 48.95万
  • 项目类别:
Mechanism of touch sensitivity in rapidly-adapting mechanosensory corpuscles
快速适应机械感觉小体的触觉敏感性机制
  • 批准号:
    10557111
  • 财政年份:
    2016
  • 资助金额:
    $ 48.95万
  • 项目类别:
Mechanism of touch sensitivity in rapidly-adapting mechanosensory corpuscles
快速适应机械感觉小体的触觉敏感性机制
  • 批准号:
    10362938
  • 财政年份:
    2016
  • 资助金额:
    $ 48.95万
  • 项目类别:
Role of Piezo2 and Nav channels in rapidly-adapting neuronal mechanoreceptors
Piezo2 和 Nav 通道在快速适应神经元机械感受器中的作用
  • 批准号:
    10063569
  • 财政年份:
    2016
  • 资助金额:
    $ 48.95万
  • 项目类别:

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