Lupus Omics Cutaneous Kidney Investigative Team (LOCKIT)
狼疮组学皮肤肾研究小组 (LOCKIT)
基本信息
- 批准号:10596281
- 负责人:
- 金额:$ 160万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2022
- 资助国家:美国
- 起止时间:2022-03-21 至 2026-12-31
- 项目状态:未结题
- 来源:
- 关键词:AccelerationAcuteAdaptive Immune SystemAddressAutoimmuneAutoimmune DiseasesB-Cell ActivationB-LymphocytesBedsBiologicalBiologyBiopsyBloodCaliforniaCause of DeathCellsChronicClinicalCollaborationsCollectionCommunitiesConsentCountryCutaneousDataData SetDatabasesDermatologistDiseaseDissociationEarly identificationElementsEndothelial CellsEnrollmentEthnic OriginExanthemaFibroblastsGeneticGoalsHeterogeneityHigh PrevalenceHospitalsImmuneImmunologicsInformed ConsentInnate Immune SystemInstitutional Review BoardsInterferon Type IInterventionInvestigationKidneyKidney DiseasesLeadLiquid substanceLupusLupus NephritisMediatingMedicineMichiganMolecularMonitorOhioOrganPathologyPathway interactionsPatient-Focused OutcomesPatientsPennsylvaniaPeriodicalsPeripheralPhasePhenotypePilot ProjectsPopulationPrevalenceProteinuriaProteomicsProtocols documentationPublishingRaceRecurrent diseaseRegistriesRegulationResearch PersonnelResearch PriorityRheumatologyRiskSalivary GlandsSamplingSan FranciscoSeveritiesSiteSkinSocioeconomic StatusSpecimenSpeedSynovial MembraneSystemic Lupus ErythematosusSystems BiologyTechnical ExpertiseTechnologyTexasTherapeuticTissue PreservationTissue ProcurementsTissuesTubular formationUnderrepresented MinorityUniversitiesUrineWomanWritingbiological specimen archivesblack womencell preparationclinical infrastructureclinical phenotypeclinically actionablecohortcollegedata pipelinedesigndigital imagingdisease classificationdisease phenotypeflexibilityimage archival systemlupus cutaneousmedical schoolsmenmonocytemulti-ethnicmultidisciplinarynext generationnovelphenotypic dataprogramsprototyperacial populationrecruitresponsescale upskin disordersuccesstranscriptomicstranslational applicationstreatment responseworking groupyoung woman
项目摘要
As the pace of discovery in the biology, genetics, and environmental regulation of SLE accelerates, the speed
and efficiency of translational application assumes even greater importance. There is now unprecedented
opportunity to harness technological advances to de-and reconstruct the enormity of phenotypic and
immunologic heterogeneity in this prototypic autoimmune disease. Building on our clinical infrastructure and
technical protocols that yielded high-quality tissue, urine and peripheral cells for transcriptomic and proteomic
analyses in AMP1, an expanded team of multi-disciplinary investigators together form the Lupus Omics
Cutaneous Kidney Investigation Team (LOCKIT) in response to the FOA: Accelerating Medicine Partnership
Autoimmune and Immune-Mediated Diseases (AMP AIM) Program. Collective team discussions aligned the
most significant scientific opportunities with clinical needs to focus on the kidney and skin, each with its own
challenging heterogeneity. Understanding the molecular underpins of both very early kidney disease (with
comparisons to data on established/relapsed disease generated in AMP1) and treatment inadequacies overall
were considered high priority goals in the field, as were differentiating acute from chronic cutaneous disease and
monitoring differences in treatment responses in these skin disease subsets. Availability of tissues to other teams
will be complementary as biology is compared across diseases. Replicating successes of AMP1, LOCKIT will
be led by the co-chairs of AMP1 SLE Clinical Working Group, Jill Buyon, NYU School of Medicine and Michelle
Petri, Johns Hopkins University. They are joined by nephrologist Brad Rovin, Ohio State University, and
dermatologist Victoria Werth, University of Pennsylvania, each recognized for translational contributions to SLE.
To accomplish our directives and assure sufficient representation of underrepresented minorities among
patients, included are three high-recruiting AMP1 sites led by Anna Broder, Albert Einstein College of Medicine;
Maria Dall’Era, University of California San Francisco; and Jennifer Anolik, University of Rochester (co-chair of
AMP1 and PI of RA site, adding B cell expertise). Two new sites, led by Karen Costenbader, Brigham and
Women’s Hospital, and Ben Chong, University of Texas, Southwestern, bring expertise in patient outcomes and
cutaneous lupus, respectively. All collaborate and publish together with cohorts collectively totaling 5,541
patients consenting to registries, and archived specimens including 98,980 longitudinal blood derivatives, and
3,311 kidney and 715 skin biopsies. To uniformly anchor discoveries, as in AMP1, Jeff Hodgin, University of
Michigan will lead a digital imaging repository. LOCKIT is poised to apply state-of-the-art technologies and next
generation analytics provided by scientific partnership with AMP AIM Cores to interrogate tissues and biologic
fluids from informative populations. Although focusing on the kidney and skin, our cohorts include all SLE
manifestations, providing agility to address other organs as AMP AIM evolves. LOCKIT commits to harmonize
and optimize all aspects of the data pipeline, from collection to analysis, interpretation and dissemination.
随着SLE在生物学、遗传学和环境调控方面的发现步伐加快
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
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Jill P Buyon其他文献
Substantiation of trophoblast transport of maternal anti-SSA/Ro autoantibodies in fetuses with rapidly progressive cardiac injury: implications for neonatal Fc receptor blockade
母体抗 SSA/Ro 自身抗体经滋养层转运至有快速进展性心脏损伤胎儿中的证据:对新生儿 Fc 受体阻断的意义
- DOI:
10.1016/s2665-9913(24)00331-x - 发表时间:
2025-01-01 - 期刊:
- 影响因子:16.400
- 作者:
Jill P Buyon;Philip M Carlucci;Bettina F Cuneo;Mala Masson;Peter Izmirly;Nalani Sachan;Justin S Brandt;Shilpi Mehta-Lee;Marc Halushka;Kristen Thomas;Melanie Fox;Colin KL Phoon;Achiau Ludomirsky;Ranjini Srinivasan;Garrett Lam;Benjamin J Wainwright;Nicola Fraser;Robert Clancy - 通讯作者:
Robert Clancy
Cardiac manifestations of neonatal lupus erythematosus: guidelines to management, integrating clues from the bench and bedside
新生儿红斑狼疮的心脏表现:管理指南,整合实验台和病床旁的线索
- DOI:
10.1038/ncprheum1018 - 发表时间:
2009-03-01 - 期刊:
- 影响因子:32.700
- 作者:
Jill P Buyon;Robert M Clancy;Deborah M Friedman - 通讯作者:
Deborah M Friedman
A Heart Disease Study of Semaglutide in Patients With Type 2 Diabetes
索马鲁肽治疗 2 型糖尿病患者的心脏病研究
- DOI:
- 发表时间:
2019 - 期刊:
- 影响因子:0
- 作者:
Devyn Zaminski;Amit Saxena;P. Izmirly;Jill P Buyon;H. M. Belmont - 通讯作者:
H. M. Belmont
Jill P Buyon的其他文献
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{{ truncateString('Jill P Buyon', 18)}}的其他基金
Stopping Hydroxychloroquine In Elderly Lupus Disease (SHIELD)
停止使用羟氯喹治疗老年狼疮病 (SHIELD)
- 批准号:
10594743 - 财政年份:2023
- 资助金额:
$ 160万 - 项目类别:
HEALTH: Harnessing Epidemiology to Advance Lupus Treatment and Health
健康:利用流行病学促进狼疮治疗和健康
- 批准号:
10668437 - 财政年份:2022
- 资助金额:
$ 160万 - 项目类别:
Lupus Omics Cutaneous Kidney Investigative Team (LOCKIT) - Pain Supplement
狼疮组学皮肤肾脏调查小组 (LOCKIT) - 疼痛补充剂
- 批准号:
10861419 - 财政年份:2022
- 资助金额:
$ 160万 - 项目类别:
Lupus Omics Cutaneous Kidney Investigative Team (LOCKIT)
狼疮组学皮肤肾研究小组 (LOCKIT)
- 批准号:
10452169 - 财政年份:2022
- 资助金额:
$ 160万 - 项目类别:
HEALTH: Harnessing Epidemiology to Advance Lupus Treatment and Health
健康:利用流行病学促进狼疮治疗和健康
- 批准号:
10552857 - 财政年份:2022
- 资助金额:
$ 160万 - 项目类别:
Surveillance and Treatment to Prevent Fetal Atrioventricular Block Likely to Occur Quickly (STOP BLOQ)
监测和治疗以预防胎儿房室传导阻滞可能很快发生(STOP BLOQ)
- 批准号:
10250529 - 财政年份:2020
- 资助金额:
$ 160万 - 项目类别:
Surveillance and Treatment to Prevent Fetal Atrioventricular Block Likely to Occur Quickly (STOP BLOQ)
监测和治疗以预防胎儿房室传导阻滞可能很快发生(STOP BLOQ)
- 批准号:
10440476 - 财政年份:2020
- 资助金额:
$ 160万 - 项目类别:
Surveillance and Treatment to Prevent Fetal Atrioventricular Block Likely to Occur Quickly (STOP BLOQ)
监测和治疗以预防胎儿房室传导阻滞可能很快发生(STOP BLOQ)
- 批准号:
10644022 - 财政年份:2020
- 资助金额:
$ 160万 - 项目类别:
Mechanisms of DNA-Specific Autoimmunity in Systemic Lupus Erythematosus
系统性红斑狼疮 DNA 特异性自身免疫机制
- 批准号:
10374852 - 财政年份:2018
- 资助金额:
$ 160万 - 项目类别:
Translational Center of Molecular Profiling in Preclinical and Established Lupus (COMPEL)
临床前和已确诊狼疮分子分析转化中心 (COMPEL)
- 批准号:
9766075 - 财政年份:2017
- 资助金额:
$ 160万 - 项目类别:
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