Lupus Omics Cutaneous Kidney Investigative Team (LOCKIT) - Pain Supplement
狼疮组学皮肤肾脏调查小组 (LOCKIT) - 疼痛补充剂
基本信息
- 批准号:10861419
- 负责人:
- 金额:$ 35.66万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2022
- 资助国家:美国
- 起止时间:2022-03-21 至 2025-12-31
- 项目状态:未结题
- 来源:
- 关键词:AccelerationAddressAdministrative SupplementAffectAnxietyAutoimmuneAutoimmune DiseasesBaseline SurveysBiological MarkersBiopsyBrain imagingCellsCharacteristicsClinicalCollaborationsCollectionConsultationsCutaneousDataDatabasesDiseaseDisease PathwayDissociationEnrollmentFatigueFibromyalgiaFunctional disorderFutureGoalsImmuneImmunohistochemistryIndividualInflammationInstitutionInvestmentsIon ChannelKidneyKnowledgeLaboratoriesLeadLeadershipLifeLupusLupus NephritisMeasuresMediatingMedicineMental DepressionMethodsMissionModalityMolecularMolecular DiseaseNational Institute of Arthritis, and Musculoskeletal, and Skin DiseasesNephritisNerveNerve FibersNeuronal PlasticityNeuropathyNeuropeptidesNociceptionOrganOutcomeOutcome AssessmentPainPain MeasurementPain ResearchPain interferencePathogenesisPatientsPhenotypePhysical FunctionPhysiciansPrevalencePruritusPsoriasisPsoriatic ArthritisQuality of lifeRaceResearchRheumatismRheumatoid ArthritisSeveritiesSiteSjogren&aposs SyndromeSkinSleep disturbancesSocial isolationStainsStromal CellsSubgroupSurveysSymptomsSyndromeSynovial MembraneSystemic Lupus ErythematosusTestingTherapeuticTimeTissuesVisualizationbasebrain magnetic resonance imagingburden of illnesscentral sensitizationchronic painclinical paincomparativedensityexpectationexperiencehigh dimensionalityindexinginnovationinsightkeratinocytelupus cutaneousmeetingsmembermicrobiomemulti-ethnicnovelpain catastrophizingpain symptompainful neuropathyparent grantparticipant enrollmentpatient subsetsprogramsrecruitresponseskin disordertissue injurytranscriptome sequencingtranscriptomic profilingtranscriptomicstreatment response
项目摘要
Clinical pain phenotypes and mechanisms in rheumatic diseases are poorly understood. The Accelerating
Medicines Partnership Autoimmune and Immune-Mediated Disease (AMP AIM) Program addresses common
themes across autoimmune diseases, and delineating the complexity and impact of pain and the dissociation
between patient and physician perceived disease burden not necessarily related to untreated inflammation is a
major unmet need. Pain phenotypes such as nociceptive (tissue injury), nociplastic (central sensitization), and
neuropathic pain and their contribution to therapeutic non-response constitutes a critical knowledge gap. Pain is
a core domain affecting quality of life from the perspective of patients with Systemic Lupus Erythematosus (SLE),
Psoriatic Spectrum Disorder (PSD), Rheumatoid Arthritis (RA) and Sjögren’s Disease (SjD). This supplement
will utilize skin biopsies acquired by the SLE and PSD disease teams in those with cutaneous disease to identify
novel pain biomarkers. Patients with lupus nephritis and SjD will be included given the importance of pain in
these patients as well and to provide further comparative insights. Governance will be under the leadership of
Jill Buyon (mPI SLE) and Alexis Ogdie (mPI PSD) with collaboration provided by other members of the respective
disease teams and consultation by Yvonne Lee bringing expertise in pain phenotyping. In parallel, efforts will be
harmonized in RA and PSD with a focus on synovial biopsies. Two specific aims are proposed. In Aim 1, pain
phenotypes will be delineated in patients with SLE, PSD, and SjD. In addition to the PROMIS 29 measures,
patients consecutively enrolled will complete the 2016 Fibromyalgia (FM) Survey Criteria and pain
catastrophizing scale. Over 2 years, the SLE team will enroll patients with active skin disease (N=20) and/or new
onset nephritis (N=40), the PSD team will enroll patients with psoriasis and/or PSA (N=30), and patients with
varying clinical and/or laboratory characteristics consistent with SjD (N=20) will be recruited by this third team.
In Aim 2, differences in skin biomarkers and functional brain MRI among patients with SLE, PSD, and SjD with
and without concomitant FM or pain sensitization will be assessed. This aim leverages studies planned to
investigate lesional and non-lesional skin from patients with cutaneous LE and PSD to test the hypothesis that
local nerves play a role in pain sensitization and itch. Following baseline surveys, a subset of patients with skin
biopsies with differing pain phenotypes will undergo functional brain imaging. With systematic collection of deeply
phenotyped patients and extensive omics derived from tissue as a part of AMP AIM, substantial innovations in
pain research are expected.
风湿性疾病的临床疼痛表型和机制知之甚少。加速
药物伙伴关系自身免疫和免疫介导的疾病(AMP AIM)计划解决常见的
跨自身免疫性疾病的主题,并描绘疼痛和解离的复杂性和影响,
在患者和医生之间,认为疾病负担不一定与未经治疗的炎症相关,
未满足的重大需求。疼痛表型,如伤害性(组织损伤),伤害性(中枢致敏),和
神经性疼痛及其对治疗无反应的贡献构成了关键的知识缺口。疼痛是
从系统性红斑狼疮(SLE)患者的角度来看,这是影响生活质量的核心领域,
银屑病谱系障碍(PSD)、风湿性关节炎(RA)和干燥病(SjD)。这种补充剂
将利用SLE和PSD疾病团队在皮肤病患者中获得的皮肤活检,
新的疼痛生物标志物。考虑到疼痛在治疗中的重要性,将纳入狼疮性肾炎和SjD患者。
这些患者也是如此,并提供进一步的比较见解。治理工作将由
Jill Buyon(mPI SLE)和Alexis Ogdie(mPI PSD)与各自的其他成员合作
疾病团队和咨询Yvonne Lee带来的疼痛表型的专业知识。与此同时,将努力
在RA和PSD中协调,重点是滑膜活检。提出了两个具体目标。目标1:疼痛
将在SLE、PSD和SjD患者中描述表型。除了PROMIS 29措施外,
连续入组的患者将完成2016年纤维肌痛(FM)调查标准,
灾难规模在2年内,SLE团队将招募活动性皮肤病患者(N=20)和/或新发
发病性肾炎(N=40),PSD团队将招募银屑病和/或PSA患者(N=30)以及患有
第三组将招募符合SjD的不同临床和/或实验室特征的患者(N=20)。
在目标2中,SLE、PSD和SjD患者的皮肤生物标志物和功能性脑MRI的差异,
并且没有伴随FM或疼痛致敏。这一目标利用了计划进行的研究,
研究皮肤LE和PSD患者的病变和非病变皮肤,以检验以下假设:
局部神经在疼痛敏化和瘙痒中起作用。在基线调查后,一部分皮肤病患者
具有不同疼痛表型的活组织检查将进行功能性脑成像。通过系统的收集,
作为AMP AIM的一部分,表型患者和来自组织的广泛组学,
预计将进行疼痛研究。
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
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Jill P Buyon其他文献
Substantiation of trophoblast transport of maternal anti-SSA/Ro autoantibodies in fetuses with rapidly progressive cardiac injury: implications for neonatal Fc receptor blockade
母体抗 SSA/Ro 自身抗体经滋养层转运至有快速进展性心脏损伤胎儿中的证据:对新生儿 Fc 受体阻断的意义
- DOI:
10.1016/s2665-9913(24)00331-x - 发表时间:
2025-01-01 - 期刊:
- 影响因子:16.400
- 作者:
Jill P Buyon;Philip M Carlucci;Bettina F Cuneo;Mala Masson;Peter Izmirly;Nalani Sachan;Justin S Brandt;Shilpi Mehta-Lee;Marc Halushka;Kristen Thomas;Melanie Fox;Colin KL Phoon;Achiau Ludomirsky;Ranjini Srinivasan;Garrett Lam;Benjamin J Wainwright;Nicola Fraser;Robert Clancy - 通讯作者:
Robert Clancy
Cardiac manifestations of neonatal lupus erythematosus: guidelines to management, integrating clues from the bench and bedside
新生儿红斑狼疮的心脏表现:管理指南,整合实验台和病床旁的线索
- DOI:
10.1038/ncprheum1018 - 发表时间:
2009-03-01 - 期刊:
- 影响因子:32.700
- 作者:
Jill P Buyon;Robert M Clancy;Deborah M Friedman - 通讯作者:
Deborah M Friedman
A Heart Disease Study of Semaglutide in Patients With Type 2 Diabetes
索马鲁肽治疗 2 型糖尿病患者的心脏病研究
- DOI:
- 发表时间:
2019 - 期刊:
- 影响因子:0
- 作者:
Devyn Zaminski;Amit Saxena;P. Izmirly;Jill P Buyon;H. M. Belmont - 通讯作者:
H. M. Belmont
Jill P Buyon的其他文献
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{{ truncateString('Jill P Buyon', 18)}}的其他基金
Stopping Hydroxychloroquine In Elderly Lupus Disease (SHIELD)
停止使用羟氯喹治疗老年狼疮病 (SHIELD)
- 批准号:
10594743 - 财政年份:2023
- 资助金额:
$ 35.66万 - 项目类别:
HEALTH: Harnessing Epidemiology to Advance Lupus Treatment and Health
健康:利用流行病学促进狼疮治疗和健康
- 批准号:
10668437 - 财政年份:2022
- 资助金额:
$ 35.66万 - 项目类别:
Lupus Omics Cutaneous Kidney Investigative Team (LOCKIT)
狼疮组学皮肤肾研究小组 (LOCKIT)
- 批准号:
10452169 - 财政年份:2022
- 资助金额:
$ 35.66万 - 项目类别:
Lupus Omics Cutaneous Kidney Investigative Team (LOCKIT)
狼疮组学皮肤肾研究小组 (LOCKIT)
- 批准号:
10596281 - 财政年份:2022
- 资助金额:
$ 35.66万 - 项目类别:
HEALTH: Harnessing Epidemiology to Advance Lupus Treatment and Health
健康:利用流行病学促进狼疮治疗和健康
- 批准号:
10552857 - 财政年份:2022
- 资助金额:
$ 35.66万 - 项目类别:
Surveillance and Treatment to Prevent Fetal Atrioventricular Block Likely to Occur Quickly (STOP BLOQ)
监测和治疗以预防胎儿房室传导阻滞可能很快发生(STOP BLOQ)
- 批准号:
10250529 - 财政年份:2020
- 资助金额:
$ 35.66万 - 项目类别:
Surveillance and Treatment to Prevent Fetal Atrioventricular Block Likely to Occur Quickly (STOP BLOQ)
监测和治疗以预防胎儿房室传导阻滞可能很快发生(STOP BLOQ)
- 批准号:
10440476 - 财政年份:2020
- 资助金额:
$ 35.66万 - 项目类别:
Surveillance and Treatment to Prevent Fetal Atrioventricular Block Likely to Occur Quickly (STOP BLOQ)
监测和治疗以预防胎儿房室传导阻滞可能很快发生(STOP BLOQ)
- 批准号:
10644022 - 财政年份:2020
- 资助金额:
$ 35.66万 - 项目类别:
Mechanisms of DNA-Specific Autoimmunity in Systemic Lupus Erythematosus
系统性红斑狼疮 DNA 特异性自身免疫机制
- 批准号:
10374852 - 财政年份:2018
- 资助金额:
$ 35.66万 - 项目类别:
Translational Center of Molecular Profiling in Preclinical and Established Lupus (COMPEL)
临床前和已确诊狼疮分子分析转化中心 (COMPEL)
- 批准号:
9766075 - 财政年份:2017
- 资助金额:
$ 35.66万 - 项目类别:
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