Clinical evaluation of advanced prototype medical device for dental caries assessment

用于龋齿评估的先进原型医疗设备的临床评价

• 批准号: 101876
• 金额: $ 37.84万
• 依托单位: CALCIVIS LIMITED
• 依托单位国家: 英国
• 项目类别: Collaborative R&D
• 财政年份: 2014
• 资助国家: 英国
• 起止时间: 2014 至 无数据
• 项目状态: 已结题
• 来源: https://gtr.ukri.org/projects?ref=101876
• 关键词: Clinical; evaluation; advanced; prototype; medical

This project will design, develop, produce and clinically evaluate an advanced prototype of the Calcivis dental caries (decay) activity assessment system. There is a significant unmet need in dentistry to differentiate early dental lesions that are actively demineralising from those which are less likely to progress to cavitation. Calcivis is unique and innovative because it deploys a photoprotein which produces light in the presence of the calcium ions being released from an actively demineralising tooth surface. In combination with a customised intra-oral camera it produces a demineralisation map of the tooth surface. To date, a basic prototype of the camera has been used to demonstrate proof of concept in extracted teeth but this project takes a significant step forward as it enables an advanced prototype reflecting detailed input from dentists to be refined, produced and evaluated in the clinic.

该项目将设计、开发、生产和临床评估Calciis龋齿(龋齿)活动评估系统的先进原型。在牙科领域，有一个重要的未得到满足的需求，即区分正在积极脱矿的早期牙齿病变和那些不太可能进展为空洞的病变。Calciis是独特的和创新的，因为它部署了一种光蛋白，当钙离子从活跃的脱矿牙齿表面释放出来时，它就会产生光。与定制的口腔内摄像头相结合，它可以生成牙齿表面的脱矿地图。到目前为止，相机的基本原型已经用于演示拔出的牙齿的概念证明，但这个项目向前迈出了重要的一步，因为它使反映牙医详细输入的先进原型能够在临床上得到改进、生产和评估。