Historical trauma and resilience as a biological state and its association with the effects of the traditional Indigenous food chokeberry

作为一种生物状态的历史创伤和复原力及其与传统土著食物野莓的影响的关联

• 批准号: 10596987
• 负责人: Nicole Redvers
• 金额: $ 19.73万
• 依托单位: UNIVERSITY OF NORTH DAKOTA
• 依托单位国家: 美国
• 财政年份: 2021
• 资助国家: 美国
• 起止时间: 2021-03-01 至 2026-02-28
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10596987
• 关键词: Adult; Affect; American; American Indians; Anxiety; Area; Attenuated; Biological; Biological Markers; Black Chokecherry Tree; Blood Pressure; Canada; Centers of Research Excellence; Chronic Disease; Collection; Communities; Complex; Consumption; Cross-Sectional Studies; Cultural Backgrounds; DNA; Data Collection; Development; Diabetes Mellitus; Dietary Intervention; Environment; Environmental Risk Factor; Epigenetic Process; Exposure to; Fatty acid glycerol esters; Food; Functional disorder; Gene Expression; Gene Mutation; Generalized Anxiety Disorder; Genes; Genetic; Glucose; Goals; Great Plains; Health; Heart Diseases; Household; Human; IL6 gene; Indigenous; Individual; Inflammatory; Institution; Interleukin-6; Juice; Lipids; Longitudinal Studies; Measures; Mediating; Medicine; Mental Depression; Mental Health; Metabolic; Metabolic Marker; Metabolism; Methylation; Modeling; Nutritional; Outcome; Outcome Measure; Participant; Patients; Phase; Physiological; Population; Post-Traumatic Stress Disorders; Prevalence; Prevention strategy; Process; Public Health; Questionnaires; Reduce health disparities; Research; Research Design; Research Project Grants; Resources; Serum; Smoking; Testing; Time; Trauma; Trauma Research; United States; adverse childhood events; alcohol misuse; blood lipid; community engagement; conditioning; dietary; disparity elimination; epigenetic marker; food consumption; health data; health equity; imprint; improved; inflammatory marker; innovation; interest; knowledge base; metabolic profile; neglect; nutrition; pediatric trauma; promote resilience; resilience; resilience factor; resilience research; resilience scale; secondary outcome; social; tool; western diet

Project Abstract Achieving health equity and eliminating disparities has been especially slow in American Indian populations even though reducing health disparities continues to be a major goal of public health institutions. American Indian populations continue to suffer disproportionately from health problems including such nutrition-related chronic diseases as diabetes and heart disease. This research project will therefore investigate how a traditional Indigenous food called chokeberry (Aronia melanocarpa) impacts epigenetic and metabolic health in relation to resiliency markers in fifty Great Plains Indian participants. Chokeberry is an Indigenous traditional food and medicine used on its own or in mixtures of pemmican (a mixture of buffalo, fat and chokeberry) common before Western contact in certain areas of the United States and Canada. Due to chokeberry’s positive effects on human lipid and glucose measures, in addition to inflammation markers demonstrated in prior studies in non-Indigenous settings, it is worthy of further exploration in this population with very different gene and metabolic profiles. Also, the process of research with American Indian communities is significant in that it can inform best practices in community engagement orientations, approaches, and models in future research settings. Our specific aims are to explore gene expression changes that are mediated by the consumption of traditional Indigenous chokeberry in Great Plains Indians and to examine the associations between metabolic end points, epigenetics, adverse childhood experiences, and mental health with and without the consumption of chokeberry in Great Plains Indians. Our long-term aim is to increase the knowledge base on the relationships between American Indian traditional food consumption, gene expression changes and metabolic markers in relation to trauma and resilience. Our study is a mix of a cross-sectional and longitudinal study design. Baseline epigenetic, metabolic and mental health data will be collected from study participants for cross sectional analysis, with the epigenetic screen specifically repeated after the post prandial consumption of chokeberry juice to assess its effects from baseline. The epigenetic, metabolic and mental health data collection process will then be repeated after 6 weeks of the daily consumption of chokeberry juice to compare the collection variables to the previous time collections.

项目摘要 在美洲印度 即使减少健康差异仍然是公共卫生机构的主要目标，人口也是如此。 美洲印第安人的人口继续因健康问题而遭受不成比例的痛苦 作为糖尿病和心脏病，与营养有关的慢性疾病。因此，该研究项目将 调查传统的土著食品如何称为乔贝里（Aronia Melanocarpa）如何影响表观遗传和 与五十个大平原印度参与者的弹性标记有关的代谢健康。乔莓是一个 本地使用或混合了pemmican的土著传统食品和药物（水牛，脂肪的混合物 和Choceberry）在美国和加拿大某些地区进行西方接触之前的常见。由于 除炎症标记外 在非土著环境中的先前研究中证明，值得在该人群中进一步探索 具有非常不同的基因和代谢谱。此外，与美洲印第安人的研究过程 社区很重要，因为它可以为社区参与方向的最佳实践提供信息， 方法和未来研究环境中的模型。 我们的具体目的是探索通过传统消费介导的基因表达变化 在大平原印第安人的土著乔莓，并检查代谢终点之间的关联， 表观遗传学，不利的童年经历以及心理健康 在大平原印第安人的乔莓。我们的长期目标是增加关系的知识基础 在美洲印第安人传统粮食消费之间，基因表达变化和代谢标记 与创伤和韧性有关。 我们的研究是横截面和纵向研究设计的混合。基线表观遗传学，代谢和 心理健康数据将从研究参与者中收集以进行横截面分析，并具有表观遗传学 屏幕列出后培养基果汁后专门重复了 基线。然后，将在6点后重复表观遗传，代谢和心理健康数据收集过程 每天消费冰川汁以比较收集变量与上一次的几周 收藏。