Advanced Assessment of Auditory-Vocal Affect in Autism with Speech and Music
通过言语和音乐对自闭症患者的听觉-声音影响进行高级评估
基本信息
- 批准号:10596158
- 负责人:
- 金额:$ 17.96万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2020
- 资助国家:美国
- 起止时间:2020-04-01 至 2025-03-31
- 项目状态:未结题
- 来源:
- 关键词:AcousticsAddressAdultAffectAffectiveAnimalsApplications GrantsAuditoryBasic ScienceBehavioralBig DataBiological AssayBloodBrain DiseasesClinicalClinical ResearchCollectionCommunicationComplexDataDepressed moodDescriptorDiagnosisDimensionsDoseFaceFoundationsFunctional disorderFutureGeneral PopulationGenerationsGoalsHappinessHearing TestsHumanImpairmentIndividualIndividual DifferencesInternetIntranasal AdministrationInvestigationKnowledgeLaboratory StudyLanguageLeadLinguisticsMajor Depressive DisorderMeasuresMental HealthModelingMusicNatureNeedlesNeurobiologyNeuroendocrinologyNeuropeptidesOutcomeOxytocinPerceptionPerformancePlacebosPoetryPsychometricsPublicationsResearchResearch MethodologyResearch PersonnelRoleSchizophreniaSignal TransductionSocial BehaviorSocial FunctioningSpeechSpeech PerceptionStatistical MethodsStimulusSystemTestingThinnessTimeTrainingUncertaintyVariantVisualVoiceadult with autism spectrum disorderauditory processingautism spectrum disorderautisticbasebehavioral phenotypingclinically relevantdesigndigitalimprovedindividuals with autism spectrum disorderinnovationinsightlanguage processingneuralresponseskill acquisitionskillssocialsocial communicationsocial deficitssocial integrationsoundsynergismtraittwo-dimensional
项目摘要
It is often said that humans are visual animals, but there is little doubt that our exceptional capacity for social
communication is auditory-vocal in nature. Importantly, this capacity is not limited to conversational speech, but
is also utilized in more abstract aspects of sound ranging over proselytizing, poetry, repetitive chant, and music.
A core feature of this speech-music continuum is the ability to convey affect through sound – made possible by
an auditory-vocal functionality that has evolved to reflexively attribute affect to voice-like stimuli. A system for
processing auditory-vocal affect is critical to human social behavior: its refinement predicts social fluency, as
individuals who are skilled at sharing in affect tend to be more socially integrated; and its impairment predicts
social deficits, e.g., in autism spectrum disorder (ASD), schizophrenia, and major depressive disorder. Despite
its central role in social behavior, we lack insight into the neurobiology that underlies the processing of auditory-
vocal affect and why it fails to operate normally in prominent brain disorders. This gap in knowledge is directly
related to the absence of a psychometrically robust, objective, and efficient assay, i.e., a “gold standard” test of
Auditory-Vocal Affect. Accordingly, Aim 1 of this proposal is to develop a gold standard Test of Auditory-Vocal
Affect (the “TAVA”) and collect large-scale normative data to support it. To do so I will: (a) use a combination of
carefully designed speech and music stimuli to overcome obstacles faced by previous tests and tease apart
issues of language processing from a core impairment in auditory-vocal affect processing; and (b) deploy the
TAVA online. Aim 2 tests whether the TAVA can accurately discriminate adults with ASD from neurotypical adults
in a controlled laboratory study. And Aim 3 tests whether a single-dose of intranasally administered oxytocin vs.
placebo can “move the needle” on TAVA performance in ASD, as implicated in previous studies of affect
processing and ASD. My overarching hypothesis is that impairment in auditory-vocal affect functionality is a
fundamental but poorly defined dimension of the core social deficits that define ASD. My rationale is that deficits
in the perception of affect in speech are repeatedly described in ASD but, in contrast to visuo-facial affect, remain
under-interrogated and poorly understood. If I am successful, I will have defined a new standard for assessing
auditory-vocal affect functionality, suitable for behavioral phenotyping and as an objective assessment in ASD
specifically and in clinical research more generally. Furthermore, my results will provide a foundation for future
investigations into the neurobiological bases of auditory-vocal affect that promises to define their contribution to
social function and dysfunction in mental health. Finally, the research goals outlined here synergize with a
training plan that fills critical gaps in my basic science background. Specifically, I seek to acquire skills in
neuroendocrinology, clinical research, and advanced statistical methods that will allow me to apply my
interdisciplinary background in auditory-vocal communication – focused on speech, music, and affect – to
relevant problems in mental health research as I transition to research independence.
人们常说人类是视觉动物,但毫无疑问,我们非凡的社交能力
项目成果
期刊论文数量(11)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
Rapid evolution of the primate larynx?
- DOI:10.1371/journal.pbio.3000764
- 发表时间:2020-08-01
- 期刊:
- 影响因子:9.8
- 作者:Bowling, Daniel L.;Dunn, Jacob C.;Fitch, W. Tecumseh
- 通讯作者:Fitch, W. Tecumseh
Selection on vocal output affects laryngeal morphology in rats.
- DOI:10.1111/joa.13366
- 发表时间:2021-05
- 期刊:
- 影响因子:2.4
- 作者:Lesch R;Schwaha T;Orozco A;Shilling M;Brunelli S;Hofer M;Bowling DL;Zimmerberg B;Fitch WT
- 通讯作者:Fitch WT
Oxytocin and the social facilitation of placebo effects.
- DOI:10.1038/s41380-022-01515-9
- 发表时间:2022-06
- 期刊:
- 影响因子:11
- 作者:Itskovich, Elena;Bowling, Daniel L.;Garner, Joseph P.;Parker, Karen J.
- 通讯作者:Parker, Karen J.
Harmonicity and Roughness in the Biology of Tonal Aesthetics.
- DOI:10.1525/mp.2021.38.3.331
- 发表时间:2021-03
- 期刊:
- 影响因子:2.3
- 作者:Bowling DL
- 通讯作者:Bowling DL
Vocal similarity theory and the biology of musical tonality.
- DOI:10.1016/j.plrev.2023.05.006
- 发表时间:2023-09
- 期刊:
- 影响因子:11.7
- 作者:Bowling, Daniel L.
- 通讯作者:Bowling, Daniel L.
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Daniel Liu Bowling其他文献
Daniel Liu Bowling的其他文献
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{{ truncateString('Daniel Liu Bowling', 18)}}的其他基金
Advanced Assessment of Auditory-Vocal Affect in Autism with Speech and Music
通过言语和音乐对自闭症患者的听觉-声音影响进行高级评估
- 批准号:
10399452 - 财政年份:2020
- 资助金额:
$ 17.96万 - 项目类别:
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