Rural Drug Addiction Research Center

农村戒毒研究中心

• 批准号: 10596483
• 负责人: Rick A Bevins
• 金额: $ 229.26万
• 依托单位: UNIVERSITY OF NEBRASKA LINCOLN
• 依托单位国家: 美国
• 财政年份: 2019
• 资助国家: 美国
• 起止时间: 2019-04-05 至 2024-03-07
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10596483
• 关键词: Address; Affect; Age; Appalachian Region; Area; Attention; Basic Science; Behavioral; Biological; Center for Translational Science Activities; Cessation of life; Chronic; Clinical; Cognitive; Collaborations; Communities; Community Health; Complex; Computer Simulation; Contracts; Country; Coupled; Data; Dedications; Development; Discipline; Disease; Disease Outbreaks; Drug Addiction; Drug abuse; Drug usage; Drug user; Economics; Emotional; Ensure; Environment; Epidemiology; Etiology; Faculty; Family; Feedback; Funding; Gender; Geography; Goals; Growth; HIV Infections; Health; Health Sciences; Health Status; Human Biology; Illicit Drugs; Immunology; Income; Indiana; Infection; Infrastructure; Injecting drug user; Injections; Institution; Interdisciplinary Study; Intervention; Lead; Life; Link; Longitudinal cohort study; Masks; Medical; Medical center; Medicine; Mentors; Methamphetamine; Microscopic; Nature; Nebraska; Nervous System Physiology; Neurology; Neuropharmacology; Neurosciences; Opiate Addiction; Outcome; Overdose; Pathology; Pattern; Persons; Pharmaceutical Preparations; Physiological; Pilot Projects; Policies; Process; Reaction; Regulation; Relapse; Research; Research Personnel; Research Project Grants; Research Support; Resources; Rural; Rural Health; Rural drug addiction; Scientist; Sexually Transmitted Diseases; Social Environment; Social Network; Social Work; Societies; Stimulant; Synapses; Technical Expertise; Time; Translating; United States; United States Dept. of Health and Human Services; Universities; University resources; Virus Diseases; Work; addiction; career; cocaine use; cohort; collaborative environment; combat; drug market; evidence base; health care availability; health science research; illicit drug use; news; pre-clinical; prevent; psychosocial; recruit; research facility; rural area; rural drug use; rural setting; service organization; service providers; simulation; social; social stigma; social stressor; software development; substance use treatment; urban area; violence exposure; virtual

PROJECT ABSTRACT The nature and challenge of illicit drug use in the United States continues to change rapidly, evolving in reaction to myriad social, economic, and local forces. While drug addiction affects every region of the country, most information about drug use comes from large urban areas. Emerging data on rural addiction and its harms justify greater attention. Record drug use, addiction, and overdose rates in rural states, coupled with a dearth of treatment facilities, point to a rapidly worsening health situation. While health sciences have made considerable progress in understanding the etiology of drug use and uncovering the link between drug use and its many associated harms, this promising scientific news has yet to translate to better rural health outcomes. The goal of this application is to create a sustainable, nationally recognized Center—the Rural Drug Addition Research Center (RDAR)—dedicated to understanding the causes and impacts of rural drug addiction and its related challenges and harms. Given the multifactorial nature of addiction, this research must unfold across a continuum of domains, ranging from the microscopic level of the synapse to larger social contexts. As such, RDAR will draw on senior investigators and existing resources from the University of Nebraska to mentor early career scientists in conducting cutting-edge research that addresses rural drug use challenges from multiple angles (i.e., from synapse to society). For example, initial research projects will focus on the neuroscience of addiction, cognitive implications of chronic drug use, the relationship between rural drug use and violence exposure, and spatial and structural simulation of drug-related disease epidemiology. To support these projects, RDAR will found the Longitudinal Networks Core (LNC), a research core built around cutting-edge cohort tracking and retention software developed by RDAR senior investigators to offer longitudinal cohort study capacity to RDAR projects. LNC will recruit and retain a cohort of rural drug users from which RDAR projects will regularly collect data. The Center will provide dedicated mentoring, professional development, and Center resources to enable early stage investigators engaged in rural drug addiction research to become independently funded researchers (Aim 1) while creating a sustainable environment for interdisciplinary research excellence on rural illicit drug use and its harms (Aim 2). This will lay the groundwork for long-term Center infrastructure (Aim 3) that allows RDAR researchers to lead efforts to address specific challenges raised by drug addiction in rural settings and develop appropriate interventions for those settings. RDAR will combine the resources of a nationally recognized research university (University of Nebraska-Lincoln) and a university-based medical center (University of Nebraska Medical Center) to create a sustainable research environment, capitalizing on existing collaborations with local practitioners and state policy and service organizations. Lastly, institutional support in the form of pilot project funding and new faculty hires in research areas important to RDAR will help ensure the long-term sustainability of the Center.

项目摘要 美国非法药物使用的性质和挑战继续迅速改变，反应发展 对无数的社会，经济和地方力量。尽管吸毒成瘾会影响该国的每个地区，但大多数 有关吸毒的信息来自大型城市地区。关于粗糙及其危害的新兴数据证明了 更加关注。在农村国家记录毒品使用，成瘾和过量率，并死亡 治疗设施，表明健康状况迅速后悔。虽然健康科学已经做了很多 理解药物使用的病因的进展，并揭示了吸毒及其许多人之间的联系 相关的危害，这个有希望的科学新闻尚未转化为更好的粗略健康状况。目标 该应用是为了创建一个可持续的，全国认可的中心 - 农村毒品添加研究 中心（RDAR） - 用于了解粗糙药物成瘾的原因和影响及其相关的原因 挑战和危害。鉴于成瘾的多因素性质，这项研究必须在连续体之间进行 从突触的显微镜水平到较大的社会环境的领域。因此，rdar会画 关于内布拉斯加州大学到心理早期职业科学家的高级研究人员和现有资源 在进行尖端研究时，从多个角度（即，从 向社会突触）。例如，最初的研究项目将重点放在成瘾，认知的神经科学上 长期使用药物使用的含义，粗糙的毒品使用与暴力暴露之间的关系以及空间和 药物相关疾病流行病学的结构模拟。为了支持这些项目，RDAR将发现 纵向网络核心（LNC），这是一个围绕最先进的队列跟踪和保留的研究核心 RDAR高级研究人员开发的软件旨在为RDAR项目提供纵向队列研究能力。 LNC将招募并保留一系列农村吸毒者，从中，RDAR项目将定期收集数据。这 中心将提供专门的心理，专业发展和中心资源以实现早期阶段 从事农村药物成瘾研究的研究人员成为独立资助的研究人员（AIM 1） 在创造可持续的环境的同时，为跨学科的研究卓越的非法药物使用及其 危害（目标2）。这将为长期中心基础设施奠定基础（AIM 3），该基础设施允许RDAR 研究人员领导着解决在粗糙环境中吸毒提出的具体挑战的努力，并发展 这些设置适当的干预措施。 RDAR将结合全国认可的资源 研究大学（内布拉斯加州林肯大学）和一个位于大学的医学中心（大学 内布拉斯加州医学中心）创建可持续的研究环境，利用现有的合作 与当地从业者以及国家政策和服务组织。最后，以飞行员形式的机构支持 对RDAR重要的研究领域的项目资金和新教师雇用将有助于确保长期 中心的可持续性。