Rural Drug Addiction Research Center

农村戒毒研究中心

• 批准号: 10596483
• 负责人: Rick A Bevins
• 金额: $ 229.26万
• 依托单位: UNIVERSITY OF NEBRASKA LINCOLN
• 依托单位国家: 美国
• 财政年份: 2019
• 资助国家: 美国
• 起止时间: 2019-04-05 至 2024-03-07
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10596483
• 关键词: Address; Affect; Age; Appalachian Region; Area; Attention; Basic Science; Behavioral; Biological; Center for Translational Science Activities; Cessation of life; Chronic; Clinical; Cognitive; Collaborations; Communities; Community Health; Complex; Computer Simulation; Contracts; Country; Coupled; Data; Dedications; Development; Discipline; Disease; Disease Outbreaks; Drug Addiction; Drug abuse; Drug usage; Drug user; Economics; Emotional; Ensure; Environment; Epidemiology; Etiology; Faculty; Family; Feedback; Funding; Gender; Geography; Goals; Growth; HIV Infections; Health; Health Sciences; Health Status; Human Biology; Illicit Drugs; Immunology; Income; Indiana; Infection; Infrastructure; Injecting drug user; Injections; Institution; Interdisciplinary Study; Intervention; Lead; Life; Link; Longitudinal cohort study; Masks; Medical; Medical center; Medicine; Mentors; Methamphetamine; Microscopic; Nature; Nebraska; Nervous System Physiology; Neurology; Neuropharmacology; Neurosciences; Opiate Addiction; Outcome; Overdose; Pathology; Pattern; Persons; Pharmaceutical Preparations; Physiological; Pilot Projects; Policies; Process; Reaction; Regulation; Relapse; Research; Research Personnel; Research Project Grants; Research Support; Resources; Rural; Rural Health; Rural drug addiction; Scientist; Sexually Transmitted Diseases; Social Environment; Social Network; Social Work; Societies; Stimulant; Synapses; Technical Expertise; Time; Translating; United States; United States Dept. of Health and Human Services; Universities; University resources; Virus Diseases; Work; addiction; career; cocaine use; cohort; collaborative environment; combat; drug market; evidence base; health care availability; health science research; illicit drug use; news; pre-clinical; prevent; psychosocial; recruit; research facility; rural area; rural drug use; rural setting; service organization; service providers; simulation; social; social stigma; social stressor; software development; substance use treatment; urban area; violence exposure; virtual

PROJECT ABSTRACT The nature and challenge of illicit drug use in the United States continues to change rapidly, evolving in reaction to myriad social, economic, and local forces. While drug addiction affects every region of the country, most information about drug use comes from large urban areas. Emerging data on rural addiction and its harms justify greater attention. Record drug use, addiction, and overdose rates in rural states, coupled with a dearth of treatment facilities, point to a rapidly worsening health situation. While health sciences have made considerable progress in understanding the etiology of drug use and uncovering the link between drug use and its many associated harms, this promising scientific news has yet to translate to better rural health outcomes. The goal of this application is to create a sustainable, nationally recognized Center—the Rural Drug Addition Research Center (RDAR)—dedicated to understanding the causes and impacts of rural drug addiction and its related challenges and harms. Given the multifactorial nature of addiction, this research must unfold across a continuum of domains, ranging from the microscopic level of the synapse to larger social contexts. As such, RDAR will draw on senior investigators and existing resources from the University of Nebraska to mentor early career scientists in conducting cutting-edge research that addresses rural drug use challenges from multiple angles (i.e., from synapse to society). For example, initial research projects will focus on the neuroscience of addiction, cognitive implications of chronic drug use, the relationship between rural drug use and violence exposure, and spatial and structural simulation of drug-related disease epidemiology. To support these projects, RDAR will found the Longitudinal Networks Core (LNC), a research core built around cutting-edge cohort tracking and retention software developed by RDAR senior investigators to offer longitudinal cohort study capacity to RDAR projects. LNC will recruit and retain a cohort of rural drug users from which RDAR projects will regularly collect data. The Center will provide dedicated mentoring, professional development, and Center resources to enable early stage investigators engaged in rural drug addiction research to become independently funded researchers (Aim 1) while creating a sustainable environment for interdisciplinary research excellence on rural illicit drug use and its harms (Aim 2). This will lay the groundwork for long-term Center infrastructure (Aim 3) that allows RDAR researchers to lead efforts to address specific challenges raised by drug addiction in rural settings and develop appropriate interventions for those settings. RDAR will combine the resources of a nationally recognized research university (University of Nebraska-Lincoln) and a university-based medical center (University of Nebraska Medical Center) to create a sustainable research environment, capitalizing on existing collaborations with local practitioners and state policy and service organizations. Lastly, institutional support in the form of pilot project funding and new faculty hires in research areas important to RDAR will help ensure the long-term sustainability of the Center.

项目摘要 美国非法药物使用的性质和挑战继续迅速变化，并在反应中不断演变 无数的社会、经济和地方力量。虽然吸毒成瘾影响到该国每个地区，但大多数 有关吸毒的信息来自大城市地区。关于农村成瘾及其危害的新数据证明了这一点 更大的关注。农村各州的吸毒、成瘾和吸毒过量率创历史新高，而且缺乏 治疗设施表明健康状况迅速恶化。虽然健康科学已经取得了相当大的成果 在了解吸毒的病因以及揭示吸毒与其许多方面之间的联系方面取得了进展 尽管存在相关危害，但这一充满希望的科学消息尚未转化为更好的农村健康成果。目标是 该申请旨在创建一个可持续的、国家认可的中心——农村药物添加研究中心 中心（RDAR）——致力于了解农村吸毒成瘾及其相关问题的原因和影响 挑战和危害。鉴于成瘾的多因素性质，这项研究必须在一个连续的过程中展开 领域，从突触的微观水平到更大的社会背景。因此，RDAR 将绘制 利用内布拉斯加大学的高级研究人员和现有资源来指导早期职业科学家 开展前沿研究，从多个角度（即从 社会突触）。例如，最初的研究项目将侧重于成瘾、认知等神经科学 慢性吸毒的影响、农村吸毒与暴力暴露之间的关系以及空间和暴力暴露之间的关系 药物相关疾病流行病学的结构模拟。为了支持这些项目，RDAR 将找到 纵向网络核心 (LNC)，一个围绕尖端队列跟踪和保留建立的研究核心 由 RDAR 高级研究人员开发的软件，为 RDAR 项目提供纵向队列研究能力。 LNC 将招募并保留一批农村吸毒者，RDAR 项目将定期从中收集数据。这 中心将提供专门的指导、专业发展和中心资源，以实现早期阶段 从事农村毒瘾研究的调查员成为独立资助的研究人员（目标1） 同时为农村非法药物使用及其相关问题的跨学科研究创造可持续的环境 危害（目标 2）。这将为长期中心基础设施（目标 3）奠定基础，使 RDAR 研究人员领导努力解决农村地区吸毒成瘾带来的具体挑战，并制定 针对这些环境采取适当的干预措施。 RDAR 将整合国家认可的资源 研究型大学（内布拉斯加大学林肯分校）和大学医学中心（内布拉斯加大学林肯分校） 内布拉斯加州医学中心）利用现有合作创造一个可持续的研究环境 与当地从业者以及国家政策和服务组织合作。最后，试点形式的制度支持 对 RDAR 重要的研究领域的项目资助和新教员的聘用将有助于确保长期 中心的可持续性。