Rural Drug Addiction Research Center

农村戒毒研究中心

• 批准号: 10596483
• 负责人: Rick A Bevins
• 金额: $ 229.26万
• 依托单位: UNIVERSITY OF NEBRASKA LINCOLN
• 依托单位国家: 美国
• 财政年份: 2019
• 资助国家: 美国
• 起止时间: 2019-04-05 至 2024-03-07
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10596483
• 关键词: Address; Affect; Age; Appalachian Region; Area; Attention; Basic Science; Behavioral; Biological; Center for Translational Science Activities; Cessation of life; Chronic; Clinical; Cognitive; Collaborations; Communities; Community Health; Complex; Computer Simulation; Contracts; Country; Coupled; Data; Dedications; Development; Discipline; Disease; Disease Outbreaks; Drug Addiction; Drug abuse; Drug usage; Drug user; Economics; Emotional; Ensure; Environment; Epidemiology; Etiology; Faculty; Family; Feedback; Funding; Gender; Geography; Goals; Growth; HIV Infections; Health; Health Sciences; Health Status; Human Biology; Illicit Drugs; Immunology; Income; Indiana; Infection; Infrastructure; Injecting drug user; Injections; Institution; Interdisciplinary Study; Intervention; Lead; Life; Link; Longitudinal cohort study; Masks; Medical; Medical center; Medicine; Mentors; Methamphetamine; Microscopic; Nature; Nebraska; Nervous System Physiology; Neurology; Neuropharmacology; Neurosciences; Opiate Addiction; Outcome; Overdose; Pathology; Pattern; Persons; Pharmaceutical Preparations; Physiological; Pilot Projects; Policies; Process; Reaction; Regulation; Relapse; Research; Research Personnel; Research Project Grants; Research Support; Resources; Rural; Rural Health; Rural drug addiction; Scientist; Sexually Transmitted Diseases; Social Environment; Social Network; Social Work; Societies; Stimulant; Synapses; Technical Expertise; Time; Translating; United States; United States Dept. of Health and Human Services; Universities; University resources; Virus Diseases; Work; addiction; career; cocaine use; cohort; collaborative environment; combat; drug market; evidence base; health care availability; health science research; illicit drug use; news; pre-clinical; prevent; psychosocial; recruit; research facility; rural area; rural drug use; rural setting; service organization; service providers; simulation; social; social stigma; social stressor; software development; substance use treatment; urban area; violence exposure; virtual

PROJECT ABSTRACT The nature and challenge of illicit drug use in the United States continues to change rapidly, evolving in reaction to myriad social, economic, and local forces. While drug addiction affects every region of the country, most information about drug use comes from large urban areas. Emerging data on rural addiction and its harms justify greater attention. Record drug use, addiction, and overdose rates in rural states, coupled with a dearth of treatment facilities, point to a rapidly worsening health situation. While health sciences have made considerable progress in understanding the etiology of drug use and uncovering the link between drug use and its many associated harms, this promising scientific news has yet to translate to better rural health outcomes. The goal of this application is to create a sustainable, nationally recognized Center—the Rural Drug Addition Research Center (RDAR)—dedicated to understanding the causes and impacts of rural drug addiction and its related challenges and harms. Given the multifactorial nature of addiction, this research must unfold across a continuum of domains, ranging from the microscopic level of the synapse to larger social contexts. As such, RDAR will draw on senior investigators and existing resources from the University of Nebraska to mentor early career scientists in conducting cutting-edge research that addresses rural drug use challenges from multiple angles (i.e., from synapse to society). For example, initial research projects will focus on the neuroscience of addiction, cognitive implications of chronic drug use, the relationship between rural drug use and violence exposure, and spatial and structural simulation of drug-related disease epidemiology. To support these projects, RDAR will found the Longitudinal Networks Core (LNC), a research core built around cutting-edge cohort tracking and retention software developed by RDAR senior investigators to offer longitudinal cohort study capacity to RDAR projects. LNC will recruit and retain a cohort of rural drug users from which RDAR projects will regularly collect data. The Center will provide dedicated mentoring, professional development, and Center resources to enable early stage investigators engaged in rural drug addiction research to become independently funded researchers (Aim 1) while creating a sustainable environment for interdisciplinary research excellence on rural illicit drug use and its harms (Aim 2). This will lay the groundwork for long-term Center infrastructure (Aim 3) that allows RDAR researchers to lead efforts to address specific challenges raised by drug addiction in rural settings and develop appropriate interventions for those settings. RDAR will combine the resources of a nationally recognized research university (University of Nebraska-Lincoln) and a university-based medical center (University of Nebraska Medical Center) to create a sustainable research environment, capitalizing on existing collaborations with local practitioners and state policy and service organizations. Lastly, institutional support in the form of pilot project funding and new faculty hires in research areas important to RDAR will help ensure the long-term sustainability of the Center.

项目摘要 美国非法药物使用的性质和挑战继续迅速变化，在反应方面不断演变 对无数的社会、经济和地方力量。虽然毒瘾影响到这个国家的每个地区，但大多数 有关毒品使用的信息来自大城市地区。关于农村成瘾及其危害的新数据证明 更多的关注。在农村州，创纪录的药物使用、成瘾和过量服药率，再加上缺乏 治疗设施，表明健康状况正在迅速恶化。虽然健康科学已经做出了相当大的贡献 了解药物使用的病因学和揭示药物使用与其多种因素之间的联系的进展 尽管存在相关的危害，但这一充满希望的科学消息尚未转化为更好的农村卫生结果。的目标是 这项申请是为了创建一个可持续的、国家认可的中心--农村药物添加研究 中心(RDAR)-致力于了解农村吸毒成瘾的原因和影响及其相关 挑战和危害。鉴于成瘾的多因素性质，这项研究必须在一个连续体中展开 从突触的微观层面到更大的社会背景。因此，RDAR将抽签 关于来自内布拉斯加大学的高级研究人员和现有资源，以指导早期职业科学家 开展前沿研究，从多个角度应对农村毒品使用挑战(即从 对社会的突触)。例如，最初的研究项目将集中在成瘾、认知的神经科学上。 长期吸毒的影响，农村吸毒与暴力暴露之间的关系，以及空间和 药物相关疾病流行病学的结构模拟。为了支持这些项目，RDAR将找到 纵向网络核心(LNC)，围绕前沿队列跟踪和保留构建的研究核心 由RDAR高级研究人员开发的软件，为RDAR项目提供纵向队列研究能力。 LNC将招募和保留一批农村吸毒者，RDAR项目将定期从他们那里收集数据。这个 中心将提供专门的指导、专业发展和中心资源，以实现早期阶段 从事农村毒瘾研究的调查人员将成为独立资助的研究人员(目标1) 同时为农村非法药物使用及其相关问题的跨学科研究创造可持续的环境 伤害(目标2)。这将为允许RDAR的长期中心基础设施(AIM 3)奠定基础 研究人员领导努力解决农村地区吸毒成瘾带来的具体挑战，并制定 针对这些环境的适当干预措施。RDAR将结合全国公认的 研究型大学(内布拉斯加-林肯大学)和以大学为基础的医学中心(内布拉斯加州大学 内布拉斯加州医疗中心)创建可持续的研究环境，利用现有的合作 与当地从业者和国家政策和服务组织合作。最后，以试点形式提供的制度支持 项目资金和对RDAR重要的研究领域的新教师招聘将有助于确保 中心的可持续性。