Translating brain to behavior: The reward-stress dysregulation model of addicted parenting

将大脑转化为行为：成瘾养育的奖励压力失调模型

• 批准号: 10594408
• 负责人: Helena JV Rutherford
• 金额: $ 20.94万
• 依托单位: YALE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2022
• 资助国家: 美国
• 起止时间: 2022-04-01 至 2025-03-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10594408
• 关键词: Acute; Affect; Affective; Area; Attention; Attenuated; Behavior; Behavioral; Birth; Brain; Caring; Child; Child Development; Child Rearing; Child Welfare; Chronic; Cognition; Crying; Cues; Data; Dependence; Drug Addiction; Drug usage; EP300 gene; Exploratory/Developmental Grant; Face; Feeling; Fostering; Functional Magnetic Resonance Imaging; Generations; Goals; Health; Infant; Infant Development; Intervention; Investigation; Laboratories; Link; Literature; Longevity; Measures; Mental disorders; Methodology; Methods; Modeling; Mothers; Motivation; National Institute of Drug Abuse; Nature; Neurobiology; Nicotine Dependence; Parents; Patient Self-Report; Personal Satisfaction; Postpartum Period; Pregnancy; Prevention; Process; Public Health; Publishing; Relapse; Research; Resources; Rewards; Risk; Sampling; Smoking; Smoking Behavior; Smoking Status; Social Interaction; Stimulus; Strategic Planning; Stress; Substance Use Disorder; Testing; Theoretical model; Thinking; Time; Tobacco smoking behavior; Translating; Visit; Woman; Work; addiction; addiction liability; behavior measurement; caregiving; drug abuse prevention; high reward; high risk; improved; intergenerational; maternal caregiving; maternal cigarette smoking; neural; neural circuit; neural correlate; neurobiological mechanism; non-smoking; pleasure; pregnant; prevent; response; smoking addiction; smoking cessation; substance use; theories; transmission process; visual processing; visual stimulus

Abstract Maternal addiction remains a significant public health concern, impacting the health and well-being of mothers as well as their developing child. Crucially, addiction disrupts early maternal care, increasing the vulnerability of the child to later substance use, abuse, and dependence1,2. Therefore, work in this area of parenting and addiction resonates with Goal 1 of NIDA’s strategic plan in understanding causes and consequences of drug use and addiction across the lifespan, and will inform Goal 2 in the identification of new and improved strategies to prevent drug use and its consequences. Recent efforts to advance our understanding of the impact of addiction on caregiving have employed neurobiological methods to examine how mothers respond to salient infant affective cues (infant face and cry stimuli). Such an approach has yielded convergent EEG/ERP and fMRI findings of delayed and decreased neural responses to infant cues in mothers with addiction, relative to mothers not engaged in substance use3-5. Building on this research, theoretical models have posited that addiction’s co-optation of reward neural circuits decrease the salience of infant cues and leads to the diminishment of the pleasure and reward of caregiving6-8. However, there is no empirical data that indicates the attenuated neural responses to infant affective cues measured in mothers with addiction translate to measures of caregiving behavior. This represents a significant challenge to the validity of neurobiological studies of parenting and addiction in the identification of mechanisms that may inform intervention efforts to decrease substance use and enhance caregiving and mother-child well-being. Therefore, this R21 application seeks to explore whether addiction impacts neural processing of infant affective cues and affiliated caregiving in recent mothers. Neural processing of infant cues will be accomplished through EEG/ERP methodology and caregiving in this context will incorporate self-report and observed behavior. The project will be actualized within the context of tobacco-smoking and nicotine addiction, allowing for the extension of this work to other substance use disorders.

抽象的 孕产妇成瘾仍然是一个重大的公共卫生问题，影响着母亲的健康和福祉 以及他们正在发育的孩子。至关重要的是，成瘾扰乱了早期孕产妇护理，增加了母亲的脆弱性 孩子后来的物质使用、滥用和依赖1,2。因此，在养育子女这一领域开展工作 成瘾与 NIDA 战略计划的目标 1 产生共鸣，即了解毒品的原因和后果 整个生命周期的使用和成瘾，并将为目标 2 确定新的和改进的 预防吸毒及其后果的策略。最近为增进我们对 成瘾对护理的影响采用神经生物学方法来检查母亲对成瘾的反应 显着的婴儿情感线索（婴儿面部和哭泣刺激）。这种方法已经产生了融合的 EEG/ERP 和功能磁共振成像发现，成瘾母亲对婴儿线索的神经反应延迟和减少，相对 未吸毒的母亲3-5。基于这项研究，理论模型假设 成瘾对奖励神经回路的选择降低了婴儿线索的显着性，并导致 照顾的乐趣和回报减少6-8。然而，没有经验数据表明 成瘾母亲对婴儿情感线索的神经反应减弱转化为测量结果 的护理行为。这对神经生物学研究的有效性提出了重大挑战 确定可能为干预工作提供信息的机制，以减少养育和成瘾的影响 药物滥用并加强护理和母婴福祉。因此，此 R21 应用程序旨在 探讨近年来成瘾是否影响婴儿情感线索和附属护理的神经处理 妈妈们。婴儿线索的神经处理将通过 EEG/ERP 方法和护理来完成 在此背景下，将纳入自我报告和观察到的行为。该项目将在年内实施 吸烟和尼古丁成瘾的背景，允许将这项工作扩展到其他物质 使用障碍。