Project 2: Role of LPCAT3 in Adipose Remodeling and Metabolic Diseases

项目2：LPCAT3在脂肪重塑中的作用 李美贞，系助理教授。CTAHR人类营养、食品和动物科学部 肥胖症中功能失调的脂肪组织质量较高会增加代谢性疾病的风险，主要公众 健康问题。饮食因素是脂肪重塑和全身能量代谢的重要调节因素。 以猪油为基础的高脂饮食诱导肥胖动物模型脂肪组织过度重构 代谢性疾病。根据所使用的脂肪类型的不同，它们对新陈代谢健康的影响也不同，而omega-3聚- 富含鱼油的不饱和脂肪酸有益健康，而饱和脂肪酸则有损胰岛素信号。 并引发促炎反应。我们工作的目标是阐明分子细节和 Omega-3与饱和脂肪对脂肪组织功能和保护作用的机制 全身新陈代谢。我们将测试一个新的假设，即omega-3多不饱和脂肪酸导致更健康 膜磷脂掺入改变膜生物学的脂肪组织重塑 和生物活性脂类的生产。我们将评估磷脂重塑酶的重要性。 溶血磷脂酰胆碱酰基转移酶(LPCAT)3，它优先将多不饱和脂肪酸添加到 膜磷脂，在介导omega-3多不饱和脂肪酸的有益作用中。这个 拟议的研究有望确定新的策略，以改善脂肪组织功能，从而系统地 新陈代谢健康。

Project 2: Role of LPCAT3 in Adipose Remodeling Mi-Jeong Lee, Assistant Professor, Dept. of Human Nutrition, Food and Animal Sciences, CTAHR Higher mass of dysfunctional adipose tissues in obesity increases risk of metabolic diseases, a major public health concern. Dietary factors are important regulators of adipose remodeling and systemic energy metabolism. Lard-based high fat diets induce excessive remodeling of adipose tissues in animal models of obesity and metabolic diseases. Depending on types of fat used, their effects on metabolic health vary and omega-3 poly- unsaturated fatty acids enriched in fish oil have health benefits while saturated fatty acids impair insulin signaling and induce proinflammatory responses. The objective of our work is to elucidate the molecular details and mechanisms through which omega-3 vs. saturated fat exerts protective effects on adipose tissue function and systemic metabolism. We will test a novel hypothesis that omega-3 poly-unsaturated fatty acids lead to healthier remodeling of adipose tissues through incorporation into membrane phospholipids altering membrane biology and production of bioactive lipids. We will assess the importance of a phospholipid remodeling enzyme lysophosphatidylcholine acyltransferase (LPCAT) 3, which preferentially add poly-unsaturated fatty acids into membrane phospholipids, in mediating the beneficial effects of omega-3 poly-unsaturated fatty acids. The proposed studies are expected to identify new strategies to improve adipose tissue function and hence, systemic metabolic health.