Disrupted Neural Connectivity in Empathy Deficits in Schizophrenia

精神分裂症共情缺陷的神经连接中断

• 批准号: 10595494
• 负责人: Amy M Jimenez
• 金额: --
• 依托单位: VA GREATER LOS ANGELES HEALTHCARE SYSTEM
• 依托单位国家: 美国
• 财政年份: 2018
• 资助国家: 美国
• 起止时间: 2018-10-01 至 2023-09-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10595494
• 关键词: Address; Affect; Affective; Anterior; Area; Belief; Brain; Brain region; Budgets; Categories; Cognitive; Complex; Computer Analysis; Confusion; Data; Development; Diffusion Magnetic Resonance Imaging; Disease; Doctor of Philosophy; Dorsal; Educational Intervention; Emotional; Emotions; Empathy; Environment; Evaluation; Feeling; Functional Magnetic Resonance Imaging; Goals; Graph; Healthcare; Impaired cognition; Impairment; Inferior; Inferior frontal gyrus; Infrastructure; Insula of Reil; Intervention; Knowledge; Learning; Learning Skill; Literature; Lobule; Medial; Mentors; Methods; Motor; Movement; Multimodal Imaging; Neural Network Simulation; Neurosciences Research; Outcome; Pain; Parietal; Patient Care; Patients; Pattern; Persons; Prefrontal Cortex; Process; Psychologist; Psychopathology; Psychotic Disorders; Public Health; Publishing; Research; Research Design; Research Personnel; Schizophrenia; Social Functioning; Social Interaction; Structure of superior temporal sulcus; System; Techniques; Training; Veterans; Visual; Work; career; cingulate cortex; cognitive training; comparison control; cost; evidence base; experience; functional disability; graph theory; improved; indexing; innovation; interest; mental state; network architecture; neural; neural network; neuroimaging; next generation; novel; poor communities; practical application; skill acquisition; skills; social; tractography; translational neuroscience

Social interactions are dynamic exchanges that most people navigate with ease. However, these exchanges are actually quite complex and nuanced. Indeed, Veterans with schizophrenia often find them confusing, resulting in poor social functioning. A key process underlying social interactions is empathy: the ability to understand and share the perspectives and mental states of others. The current proposal divides empathy into two major components: affective empathy and cognitive empathy. Affective empathy might be relatively intact in schizophrenia and it involves vicariously sharing another person’s mental states. Affective empathy can be further divided into two subcomponents. Motor resonance refers to the brain’s tendency to activate the same regions during first-hand action as well as second-hand observation of motor movements. Associated brain regions include the inferior parietal lobule, posterior superior temporal sulcus, and inferior frontal gyrus. Affect sharing refers to overlapping activation of brain regions during first- and second-hand experience of emotion, and is associated with dorsal anterior cingulate cortex and anterior insula brain regions. Cognitive empathy involves taking the perspective of others, and ranges from simple visual perspective taking (inferring which objects someone sees from a different view point) to emotional perspective taking (more complex inferences about another’s feelings, beliefs, and intentions). It is consistently impaired in schizophrenia Cognitive empathy is associated with the medial prefrontal cortex, precuneus and temporo-parietal junction. The complex construct of empathy requires integration and coordination among regions within and between these brain networks. The network architecture underlying empathy in schizophrenia is not known, including any alterations in connections within and between regions of these empathy networks. The goal of this proposal is address this gap in the literature. To do so, the applicant will receive training in functional and structural brain connectivity methods and apply them to a multi-modal imaging study designed to better understand where empathy processing functions break down at the neural level in Veterans with schizophrenia. Acquiring the skills outlined in the training component will allow the applicant to utilize sophisticated, cutting-edge neuroimaging methods to conduct the next generation of translational neuroscience research on psychotic disorders. The primary mentor will be Michael F. Green, PhD, Director of the VISN 22 MIRECC Treatment Unit, an established leader in the field of schizophrenia research. The applicant will work with Dr. Green and three co-mentors who are experts in their respective fields, to learn skills necessary to analyze fMRI data for functional connectivity using multivariate techniques, dMRI data for structural connectivity, and apply graph theory, an advanced computational analysis, to the study of neural connectivity patterns. The work stands to make a significant contribution to the field by moving beyond a regional neural focus toward a neural network model of underlying mechanisms of psychopathology. The applicant’s career goal is to become a VA-based research psychologist, working to advance understanding of schizophrenia while also benefiting Veterans through practical application of research findings. This CDA will facilitate the applicant’s goal of independence, providing a unique combination of skills to become a local expert and long-term VA researcher. The applicant’s training environment at the VA MIRECC/UCLA provides an excellent environment and infrastructure from which to complete the proposed study.

社交互动是动态的交流，大多数人都能轻松驾驭。然而，在这方面， 这些交流实际上是相当复杂和微妙的。事实上，患有精神分裂症的退伍军人 经常会感到困惑，导致社会功能低下。一个关键的社会过程 互动是同理心：理解和分享观点和心理状态的能力 他人目前的建议将移情分为两大部分：情感移情 和认知同理心。情感共情在精神分裂症中可能相对完整， 包括间接分享他人的精神状态情感移情可以更进一步 分为两个子组件。运动共振是指大脑倾向于激活 在第一手动作和第二手观察运动时，相同的区域。 相关的大脑区域包括下顶叶，后上级颞沟， 和额下回情感分享指的是大脑区域在 第一手和第二手的情绪体验，并与背前扣带回 皮质和前额叶脑区。认知同理心包括从 从简单的视觉透视（推断某人看到了哪些物体 从不同的观点）到情绪化的观点（更复杂的推论， 他人的感受、信念和意图）。精神分裂症患者的认知功能 同理心与内侧前额叶皮层、楔前叶和颞顶叶有关 交界处。同理心的复杂结构需要整合和协调， 这些大脑网络内部和之间的区域。同理心背后的网络结构 在精神分裂症是未知的，包括任何改变连接内部和之间 这些共情网络的区域。该提案的目标是解决 文学为此，申请人将接受大脑功能和结构方面的培训 连接方法，并将其应用于多模态成像研究，旨在更好地 了解退伍军人的同理心处理功能在神经水平上哪里发生故障， 精神分裂症获得培训部分中概述的技能将使申请人能够 利用复杂的，尖端的神经成像方法来进行下一代的 精神障碍的转化神经科学研究。主要导师是迈克尔 F.绿色，博士，主任VISN 22 MIRECC治疗单位，一个既定的领导者， 精神分裂症研究领域。申请人将与绿色博士和三位共同导师一起工作 他们都是各自领域的专家，学习分析功能磁共振成像数据所需的技能， 使用多变量技术的功能连接，结构连接的dMRI数据，以及 应用图论，先进的计算分析，神经连接的研究 模式.这项工作通过超越一个 区域神经集中到神经网络模型的潜在机制， 精神病理学申请人的职业目标是成为VA的研究心理学家， 致力于促进对精神分裂症的理解，同时也通过以下方式使退伍军人受益： 研究成果的实际应用。本CDA将有助于申请人实现以下目标： 独立性，提供独特的技能组合，成为当地专家和长期 退伍军人事务部研究员申请人在VA MIRECC/UCLA的培训环境提供了一个 良好的环境和基础设施，以完成拟议的研究。