The Oral Mycobiome and Risk of Pancreatic Cancer
The Oral Mycobiome and Risk of Pancreatic Cancer
批准号:
10493124
负责人:
Jiyoung Ahn
金额:
$62.78万
依托单位国家:
美国
项目类别:
财政年份:
2021
资助国家:
美国
项目状态:
未结题
起止时间:
2021-09-23 至 2025-08-31
关键词:
16S ribosomal RNA sequencingAddressAmerican Cancer SocietyAnimalsBacteriaBiological AssayBiomassCancer BurdenCancer Prevention Study IICandidiasisClinicalCommunitiesDataDevelopmentDiagnosisDideoxy Chain Termination DNA SequencingDiseaseEtiologyExposure toFlow CytometryGeneral PopulationGenesGeneticGenetic DiseasesGoalsHumanImmuneImmune responseImmunityImmunohistochemistryInterventionInvestigationJointsKnowledgeLeadLocationLymphoid CellMalignant NeoplasmsMalignant neoplasm of gastrointestinal tractMalignant neoplasm of pancreasMetabolicMicrobeMyeloid CellsNatural ImmunityNatureNested Case-Control StudyObesityOralOral cavityOutcomePancreasPancreatic AdenocarcinomaPancreatic DiseasesPancreatitisPatientsPersonsPhenotypePreventionPreventive measureProcessProspective StudiesReportingResearchResearch DesignRiskRisk FactorsSamplingScreening for cancerSmokingTestingTissuesTumor ImmunityTumor TissueValidationadaptive immunitybacteriomebasecancer preventioncancer riskclinical practicecohortdensitydesigndisorder riskexperimental studyfungal microbiotafungushigh riskimprovedindividualized preventioninnovationmicrobialmicrobial hostmicrobiomemicrobiotamultidisciplinarymycobiomenoveloral bacteriaoral diagnosticsoral fungaloral microbial communityoral microbiomepancreas developmentpancreatic neoplasmpancreatic tumorigenesispolymicrobial biofilmpreventprophylactictooltumortumor-immune system interactions
中文摘要
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英文摘要
ABSTRACT
We hypothesize that oral fungi potentiate pancreas carcinogenesis via the pancreas tumor immune
microenvironment. The human oral cavity hosts a diverse microbiota, including bacteria and fungi. Our team has
made novel findings that human oral bacterial microbiome is related to risk of pancreas cancer development. In
this proposal, we focus on oral fungi (the mycobiome), a “keystone” component of the oral microbiome with the
highest biomass. Clinical candidiasis and carriage of a rare candidiasis-related genetic disorder increase risk for
pancreas cancer. In our preliminary data, we made novel finding that specific oral fungi are associated with at
least 2-fold differentials in pancreatic cancer risk, and those fungi are found in pancreas tumor tissue. We recently
reported that fungi experimentally promote pancreas cancer and tumoral immune response in animals. Taken
together, these data strongly support our hypothesis.
Our ultimate goal is to identify specific oral fungal microbiota in the general population that may be managed to
prevent pancreatic cancer. Our specific aims are: 1) to test whether oral fungal microbiome is associated with
subsequent risk of pancreatic cancer in a nested case-control study and 2) to test the hypothesis that
metabolically active fungi in the pancreas influence tumor immunity. Strengths of this study include a large
prospective study design, with oral samples collected prior to cancer development, and state-of-the-art fungal
and immune phenotype assays that will accurately and comprehensively characterize fungal composition and
immune phenotypes. This is the first investigation of oral and pancreas fungal microbiome and pancreatic cancer
risk.
Pancreatic cancer is highly lethal and little is known about ways to detect and prevent this disease. We expect
to identify specific oral fungi associated with risk of pancreas cancer and to identify fungal—host pancreatic
tumor immune response. These outcomes will expand our current limited knowledge on the causes of pancreatic
cancer, will help to identify people at high risk for this disease, and may lead to microbial-based prophylactic
prevention for pancreatic cancer. Thus, findings may help to rapidly advance our ability to reduce the burden of
this highly fatal disease.
期刊论文(0)
专著(0)
科研奖励(0)
会议论文
Asian American Community Cohort of the New York Metropolitan Area
-
批准号:10724342
-
项目类别:
-
资助金额:$63.22万
-
财政年份:2023
-
负责人:Jiyoung Ahn
-
依托单位:
NYU Cancer Health Disparity (CHD) SPORE
-
批准号:10265452
-
项目类别:
-
资助金额:$112.55万
-
财政年份:2020
-
负责人:Jiyoung Ahn
-
依托单位:
Project 2
-
批准号:10044536
-
项目类别:
-
资助金额:$17.66万
-
财政年份:2020
-
负责人:Jiyoung Ahn
-
依托单位:
Administrative Core
-
批准号:10044534
-
项目类别:
-
资助金额:$20.57万
-
财政年份:2020
-
负责人:Jiyoung Ahn
-
依托单位:
Administrative Core
-
批准号:10265453
-
项目类别:
-
资助金额:$21.09万
-
财政年份:2020
-
负责人:Jiyoung Ahn
-
依托单位:
Project 2
-
批准号:10265455
-
项目类别:
-
资助金额:$16.92万
-
财政年份:2020
-
负责人:Jiyoung Ahn
-
依托单位:
NYU Cancer Health Disparity (CHD) SPORE
-
批准号:10044533
-
项目类别:
-
资助金额:$112.55万
-
财政年份:2020
-
负责人:Jiyoung Ahn
-
依托单位:
Project 1
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批准号:10652343
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项目类别:
-
资助金额:$28.09万
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财政年份:2019
-
负责人:Jiyoung Ahn
-
依托单位:
Project 1
-
批准号:10200701
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项目类别:
-
资助金额:$28.09万
-
财政年份:2019
-
负责人:Jiyoung Ahn
-
依托单位:
Project 1
-
批准号:10434087
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项目类别:
-
资助金额:$28.09万
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财政年份:2019
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负责人:Jiyoung Ahn
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依托单位:
Oral microbiome in esophageal adenocarcinoma
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批准号:8625133
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项目类别:
-
资助金额:$53.93万
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财政年份:2014
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负责人:Jiyoung Ahn
-
依托单位:
Oral microbiome in esophageal adenocarcinoma
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批准号:8823746
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项目类别:
-
资助金额:$53.93万
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财政年份:2014
-
负责人:Jiyoung Ahn
-
依托单位:
Prospective Study of Human Oral Microbiome and Pancreatic Cancer Risk
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批准号:9331444
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项目类别:
-
资助金额:$46.85万
-
财政年份:2014
-
负责人:Jiyoung Ahn
-
依托单位:
Prospective Study of Human Oral Microbiome and Pancreatic Cancer Risk
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批准号:8930079
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项目类别:
-
资助金额:$59.32万
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财政年份:2014
-
负责人:Jiyoung Ahn
-
依托单位:
Prospective Study of Human Oral Microbiome and Pancreatic Cancer Risk
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批准号:8693864
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项目类别:
-
资助金额:$44.47万
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财政年份:2014
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负责人:Jiyoung Ahn
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依托单位:
Oral microbiome in esophageal adenocarcinoma
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批准号:9250723
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项目类别:
-
资助金额:$53.93万
-
财政年份:2014
-
负责人:Jiyoung Ahn
-
依托单位:
Prospective Study of Human Oral Microbiome and Pancreatic Cancer Risk
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批准号:9128407
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项目类别:
-
资助金额:$53.33万
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财政年份:2014
-
负责人:Jiyoung Ahn
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依托单位:
Fiber Intake, Gut Bacteria Metabolites and Risk of Colorectal Cancer
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批准号:8673500
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项目类别:
-
资助金额:$16.95万
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财政年份:2013
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负责人:Jiyoung Ahn
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依托单位:
Gut Microbiome Profiles and Risk of Colorectal Cancer
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批准号:8761370
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项目类别:
-
资助金额:$5.5万
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财政年份:2013
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负责人:Jiyoung Ahn
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依托单位:
The interaction of diet, air pollution, and cardiovascular disease in NHANES.
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批准号:8259622
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项目类别:
-
资助金额:$25.43万
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财政年份:2012
-
负责人:Jiyoung Ahn
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依托单位:
海外基金