Innovative rapid culture media to aid control of bovine tuberculosis

创新的快速培养基有助于控制牛结核病

• 批准号: 102106
• 金额: $ 42.42万
• 依托单位: TIKA DIAGNOSTICS LIMITED
• 依托单位国家: 英国
• 项目类别: Collaborative R&D
• 财政年份: 2015
• 资助国家: 英国
• 起止时间: 2015 至 无数据
• 项目状态: 已结题
• 来源: https://gtr.ukri.org/projects?ref=102106
• 关键词: Innovative; rapid; culture; media; aid

Bovine tuberculosis (bTB) caused by Mycobacterium bovis is the most pressing animal health problem in the UK. 8.4 million tests for bTB were carried out in the UK leading to slaughter of 32,000 animals. Unfortunately the current diagnosis is reliant on culture of a woefully slow growing organism in conventional media that has not been improved upon for more than 50 years. Our new supplements have excellent potential to significantly reduce the time to diagnosis, massively increase effectiveness of herd screening and positively influence eradication and control programmes for bTB in the UK. We have previously shown that our approach can halve the time for growth of Mycobacterium tuberculosis from human samples. We now wish to adapt and optimise our supplement for bTB and have already preliminary data to show that this will be possible. The project proposes to extensively screen our innovative (and patented) bank of supplements to maximize enhanced growth of bTB in laboratory cultures. We propose in collaboration with AHVLA, to test clinical and environmental samples from cattle and badgers using our supplements and compare against current methods. We will then seek to market this product worldwide.

由牛分枝杆菌引起的牛结核病是英国最紧迫的动物健康问题。英国进行了840万次BTB检测，导致3.2万头动物被宰杀。不幸的是，目前的诊断依赖于在常规培养基中培养出一种生长缓慢的可悲生物，而这种培养方法50多年来一直没有得到改善。我们的新补充剂具有极好的潜力，可以显著缩短诊断时间，大幅提高群体筛查的有效性，并对英国的结核病根除和控制计划产生积极影响。我们之前已经证明，我们的方法可以将人类样本中结核分枝杆菌的生长时间减半。我们现在希望调整和优化我们的补充剂，以适应BTB，并已有初步数据表明这将是可能的。该项目建议广泛筛选我们的创新(和专利)补充剂银行，以最大限度地促进实验室培养中BTB的增长。我们建议与AHVLA合作，使用我们的补充剂测试牛和獾的临床和环境样本，并与目前的方法进行比较。然后，我们将寻求在全球范围内销售这种产品。