AGING, BRAIN IMAGING, AND COGNITION

衰老、脑成像和认知

• 批准号: 2053097
• 负责人: GODFREY D PEARLSON
• 金额: $ 34.48万
• 依托单位: JOHNS HOPKINS UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 1994
• 资助国家: 美国
• 起止时间: 1994-09-30 至 1997-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/2053097
• 关键词: age difference; brain imaging /visualization /scanning; brain mapping; cognition; epidemiology; functional ability; human old age (65+); human subject; information dissemination; magnetic resonance imaging; neuroanatomy; statistics /biometry

DESCRIPTION (Investigator's Abstract): The proposed research bridges strength of epidemiology and survey research with those of structural neuro-imaging all cognitive assessment, which are more typically conducted without close attention to the population from which normal volunteer subjects are recruited. The proposed study sample will consist of 242 adults ages 20+, selected with probability sampling so that there will be 11 men and 11 women in each of 11 age strata, with 110 of the subjects aged 65 years or older, and subfields aged 80 years and older. Selection probabilities will ensure that the samples racial distribution corresponds to the proportional representation of African-Americans and Caucasians in the U.S. adult Population, based on the U.S. census projection for 1995, and that approximately 50% of subjects with each age stratum will be high school graduates. This cross-sectional survey will investigate suspected age-related differences in neuroanatomy, cognitive functioning and performance (e.g., activities of daily living). After sampling, subjects will be recruited for office-based measurements of quantitative volumetric neuro-anatomy, using reliable measures obtained from 3-D volume-rendered MRl scans. At the same time, detailed measures of cognitive functioning, current physical health, health history and plasma lipids will all be assessed. The specific aims of the proposed study are: To assess cross- sectional age differences in generalized and regional brain measures from MRI, multiple domains of cognitive performance, and functional limitations or disability. This will yield data on specific differences across age strata as well as a set of comprehensive reference values for brain anatomy, cognition, and function across, age strata. We envisage this cross-sectional survey work serving as the basis for future prospective longitudinal studies of age-related brain anatomic changes related to impaired functioning. We will assess specific correlative inter-relationships among MRI and the sets of functional measures, investigating variation in these correlations across age strata. For example, parameters of brain structure and functional status will be examined in terms of their association with suspected sources of variation from medical history, demographic background, and current medical status. Images, reference values and other products of this research gathered in the proPosed project will be made available on-line via internet for use in other research centers; in the case of MRI images, as part of NIH's BRAIN MAP project.

描述（研究者摘要）：拟定的研究桥梁 流行病学和调查研究与结构性研究的优势 神经成像所有认知评估，这是更典型的 在没有密切关注正常人群的情况下进行， 招募志愿者。拟议的研究样本将包括 在242名20岁以上的成年人中，采用概率抽样进行选择， 将有11名男性和11名女性在11个年龄层，其中110名 年龄在65岁或以上的受试者，以及年龄在80岁或以上的子字段。 选择概率将确保样本的种族分布 相当于非洲裔美国人的比例代表制， 根据美国人口普查，美国成年人口中的高加索人 预计1995年，大约50%的受试者 年龄层将是高中毕业生。 这项横断面调查将调查疑似与年龄相关的 神经解剖学、认知功能和表现的差异 (e.g.,活动 日常生活）。 采样后，受试者将 征聘人员在办公室进行定量体积测量 神经解剖学，使用从3D体积渲染获得的可靠测量， 核磁共振扫描。与此同时，认知功能的详细测量， 目前的身体健康，健康史和血脂都将是 评估。 拟议研究的具体目标是： 广义和局部脑测量的分段年龄差异 从MRI，多个领域的认知表现，和功能 限制或残疾。这将产生关于具体差异的数据 以及一套全面的参考值， 大脑解剖学、认知和功能，跨越年龄层。 我们设想 这项横断面调查工作将作为今后 与年龄相关的脑解剖学变化的前瞻性纵向研究 与功能受损有关。我们将评估具体的相关性， MRI和功能测量集之间的相互关系， 调查这些相关性在不同年龄层中的变化。为 例如，大脑结构和功能状态的参数将被 根据其与可疑来源的联系进行审查， 病史、人口统计学背景和当前 医疗状况。图像、参考值和其他产品 该项目所收集的研究成果将在网上公布 通过互联网在其他研究中心使用;在MRI的情况下 图片，作为NIH的脑地图项目的一部分。