Salmonella in poultry: improving vaccine efficacy

家禽中的沙门氏菌：提高疫苗功效

• 批准号: LP190100864
• 负责人: Prof Kapil Chousalkar
• 金额: $ 27.67万
• 依托单位: The University of Adelaide
• 依托单位国家: 澳大利亚
• 项目类别: Linkage Projects
• 财政年份: 2020
• 资助国家: 澳大利亚
• 起止时间: 2020-11-13 至 2023-11-12
• 项目状态: 已结题
• 来源: https://dataportal.arc.gov.au/RGS/Web/Grants/LP190100864
• 关键词: Salmonella; poultry; improving; vaccine; efficacy

The central aim of this project is to increase the antigenicity of aroA mutant Salmonella Typhimurium vaccines, in particular Bioproperties’ Vaxsafe® ST. Increased antigenicity will affect the gut microbiota and stimulate a stronger host immune response improving vaccine efficacy and the duration of protection against S. Typhimurium in poultry. This will ultimately reduce bacterial loads in the farm environment, mitigate downstream contamination of the food supply chain, and reduce the number of human salmonellosis cases.

该项目的中心目标是提高 aroA 突变型鼠伤寒沙门氏菌疫苗的抗原性，特别是 Bioproperties 的 Vaxsafe® ST。抗原性的增加将影响肠道微生物群并刺激更强的宿主免疫反应，从而提高疫苗功效和在家禽中针对鼠伤寒沙门氏菌的保护持续时间。这最终将减少农场环境中的细菌负荷，减轻食品供应链的下游污染，并减少人类沙门氏菌病病例的数量。