Vaccination of poultry infected with multiple Salmonella serovars

沙门氏菌是一种人畜共患病的食源性病原体，存在于鸡蛋和禽肉中。它是人类胃肠道疾病的第二大原因，因此，减少家禽养殖场的沙门氏菌对公共卫生至关重要。该项目旨在评估一种商用鼠伤寒沙门氏菌疫苗对多种血清型的长期疗效，包括新出现的肠炎沙门氏菌。该项目将使用一种创新的方法来评估宿主对多血清型感染的反应，从而产生禽类免疫学方面的新知识。该项目的结果将在未来证明澳大利亚家禽业免受外来沙门氏菌血清型的影响，从而显著降低未来爆发的风险和经济损失，从而使该行业受益。

Salmonella is a zoonotic, foodborne pathogen found on eggs and poultry meat. It is the second largest cause of human gastrointestinal disease, thus, reduction of Salmonella on poultry farms is paramount to public health. This project aims to evaluate the long-term efficacy of a commercial Salmonella Typhimurium vaccine against multiple serotypes, including the emerging Salmonella Enteritidis. This project will generate new knowledge in avian immunology using an innovative approach to evaluate the host response to multi-serovar infection. Outcomes of this project will future proof the Australian poultry industry against exotic Salmonella serotypes benefitting the industry by significantly reducing risks of future outbreaks and economic loss.