The Fluid-Particle Mechanics of a Synthetic Jet-based Dry Powder Inhaler

合成喷射干粉吸入器的流体-颗粒力学

• 批准号: LP190100917
• 负责人: Prof Julio Soria
• 金额: $ 53.37万
• 依托单位: Monash University
• 依托单位国家: 澳大利亚
• 项目类别: Linkage Projects
• 财政年份: 2022
• 资助国家: 澳大利亚
• 起止时间: 2022-04-01 至 2025-03-31
• 项目状态: 未结题
• 来源: https://dataportal.arc.gov.au/RGS/Web/Grants/LP190100917
• 关键词: Fluid; Particle; Mechanics; Synthetic; Jet

This project aims to untangle the fundamental principles that govern the fluid mechanics and particulate interactions in a novel concept chip-based micro-zero-net-mass-flux (micro-ZNMF) jet-assisted dry powder inhaler (DPI). Respiratory diseases affect 6.2 million Australians. The treatment of these diseases is hampered by the poor efficiency of current delivery systems, with conventional DPI devices exhibiting sub-optimum performance, delivering typically less than 20% of the loaded dose to the target site, the lungs. The new fundamental knowledge resulting from this research will enable the engineering of a high-efficiency groundbreaking DPI, with the potential to be fully adaptive user-specific benefiting millions of Australians.

该项目旨在解开一个新概念的基于芯片的微零净质量通量（micro-ZNMF）喷射辅助干粉吸入器（DPI）中的流体力学和颗粒相互作用的基本原理。呼吸系统疾病影响了620万澳大利亚人。这些疾病的治疗受到当前递送系统的低效率的阻碍，常规DPI装置表现出次优性能，通常将小于20%的负载剂量递送到靶部位（肺）。从这项研究中获得的新的基础知识将使高效率的突破性DPI工程成为可能，并有可能完全适应特定用户，使数百万澳大利亚人受益。