Characterising the transport and delivery of oligonucleotides

表征寡核苷酸的运输和递送

• 批准号: LP190100433
• 负责人: Prof Killugudi Swaminatha-Iyer
• 金额: $ 39.61万
• 依托单位: The University of Western Australia
• 依托单位国家: 澳大利亚
• 项目类别: Linkage Projects
• 财政年份: 2021
• 资助国家: 澳大利亚
• 起止时间: 2021-01-27 至 2024-01-26
• 项目状态: 已结题
• 来源: https://dataportal.arc.gov.au/RGS/Web/Grants/LP190100433
• 关键词: Characterising; transport; delivery; oligonucleotides

Short RNA and DNA molecules represent a class of macromolecules that have great potential, but to facilitate their trafficking across cellular and membrane barriers into specific sites of action is challenging. This project aims to develop and apply novel imaging approaches to track them in cells and tissues. Expected outcomes include better understanding of the trafficking across cellular and membrane barriers, and improved imaging tools that could be used to further study the molecular mechanisms of accumulation, metabolism and trafficking of these molecules. This project should provide new strategies to target these molecules to specific cells and tissues, which have significant social and economic benefits to the Australian community.

短RNA和DNA分子代表了一类具有巨大潜力的大分子，但促进它们穿过细胞和膜屏障进入特定作用位点是具有挑战性的。该项目旨在开发和应用新的成像方法来跟踪细胞和组织中的它们。预期成果包括更好地了解跨细胞和膜屏障的贩运，以及改进成像工具，可用于进一步研究这些分子的积累、代谢和贩运的分子机制。该项目将提供新的策略，将这些分子靶向特定的细胞和组织，这对澳大利亚社区具有重大的社会和经济效益。