Magnetofection In An Oscillating Magnetic Field

振荡磁场中的磁转染

• 批准号: DP150104433
• 负责人: Prof Killugudi Swaminatha-Iyer
• 金额: $ 33.41万
• 依托单位: The University of Western Australia
• 依托单位国家: 澳大利亚
• 项目类别: Discovery Projects
• 财政年份: 2015
• 资助国家: 澳大利亚
• 起止时间: 2015-01-01 至 2017-12-31
• 项目状态: 已结题
• 来源: https://dataportal.arc.gov.au/RGS/Web/Grants/DP150104433
• 关键词: Magnetofection; Oscillating; Magnetic; Field

The success of genetic engineering is largely dependent on the ability of transfection agents to deliver genes. Low transfection efficiency is now widely recognised as a critical bottleneck to successful gene delivery. The recent emphasis on the development of nanoscale delivery agents has led to new physics and chemistry-based techniques, which take advantage of charge interactions and energetic processes. This multidisciplinary project aims to address this highly significant problem by developing a novel methodology to manipulate nanoparticles under the influence of an oscillating magnetic field to achieve high transfection efficiencies in a highly relevant model of epigenetic reprogramming.

基因工程的成功在很大程度上取决于转染剂递送基因的能力。低转染效率现在被广泛认为是成功基因递送的关键瓶颈。最近对纳米级递送剂的开发的重视导致了新的基于物理和化学的技术，其利用电荷相互作用和能量过程。这个多学科项目旨在通过开发一种新的方法来解决这个非常重要的问题，该方法在振荡磁场的影响下操纵纳米颗粒，以在表观遗传重编程的高度相关模型中实现高转染效率。