Magnetofection In An Oscillating Magnetic Field

基因工程的成功在很大程度上取决于转染剂传递基因的能力。低的转染率现在被广泛认为是成功的基因传递的关键瓶颈。最近对纳米级递送剂的发展的重视导致了基于物理和化学的新技术，这些技术利用电荷相互作用和能量过程。这个多学科项目旨在解决这一非常重要的问题，通过开发一种新的方法来在振荡磁场的影响下操纵纳米颗粒，以在高度相关的表观遗传重新编程模型中实现高转染率。

The success of genetic engineering is largely dependent on the ability of transfection agents to deliver genes. Low transfection efficiency is now widely recognised as a critical bottleneck to successful gene delivery. The recent emphasis on the development of nanoscale delivery agents has led to new physics and chemistry-based techniques, which take advantage of charge interactions and energetic processes. This multidisciplinary project aims to address this highly significant problem by developing a novel methodology to manipulate nanoparticles under the influence of an oscillating magnetic field to achieve high transfection efficiencies in a highly relevant model of epigenetic reprogramming.