Discovering Novel Antibiotics Agianst Highly Resistent Gram Negative Pathogens

发现针对高度耐药革兰氏阴性病原体的新型抗生素

• 批准号: 102852
• 金额: $ 116.94万
• 依托单位: NANNA THERAPEUTICS LIMITED
• 依托单位国家: 英国
• 项目类别: Collaborative R&D
• 财政年份: 2017
• 资助国家: 英国
• 起止时间: 2017 至 无数据
• 项目状态: 已结题
• 来源: https://gtr.ukri.org/projects?ref=102852
• 关键词: Discovering; Novel; Antibiotics; Agianst; Highly

Nearly all of us have taken antibiotics: they really are a 'wonder drug' saving millions of lives every year, by specifically killing bacteria. They are rapidly becoming less effective as bacteria develop ways to resist them. An example of this is the spread of MRSA in hospitals. A recent review (The O'Neill Report) conducted by the UK government with the Wellcome Trust concluded that by 2050 antibiotic resistant infections would kill more people each year than cancer, and many common medical procedures such as hip replacements or Caesarean sections will become too dangerous to perform. New antibiotics are badly needed, and soil organisms have been one of the best sources of antibiotics over the last 70 years. However, soil organisms may only make an antibiotic under certain conditions which are hard to copy outside of their natural environment, which makes identification and exploitation difficult. Bactevo have isolated hundreds of organisms from the soil and hard-wired them to make all the chemicals they can make, including antibiotics, all the time. We then screen them for their ability to kill dangerous bacteria. The work is now progressing to advance these chemicals through to the creation of novel, effective antibiotics, ensuring future generations will have access to these vital drugs.

我们几乎所有人都服用过抗生素：它们真的是一种“灵丹妙药”，每年通过专门杀死细菌来拯救数百万人的生命。随着细菌开发出抵抗它们的方法，它们正迅速变得不那么有效。耐甲氧西林金黄色葡萄球菌在医院传播就是一个例子。英国政府最近与惠康信托基金共同进行的一项审查(奥尼尔报告)得出结论，到2050年，抗药性感染每年导致的死亡人数将超过癌症，许多常见的医疗程序，如髋关节置换或剖腹产，将变得过于危险，无法进行。人们迫切需要新的抗生素，在过去的70年里，土壤微生物一直是抗生素的最佳来源之一。然而，土壤生物只能在某些条件下才能产生抗生素，这些条件很难在自然环境之外复制，这就给鉴定和开发带来了困难。Bactevo已经从土壤中分离出数百种微生物，并将它们固定在一起，以制造它们可以制造的所有化学品，包括抗生素，一直都是如此。然后我们对它们进行筛选，看它们是否有能力杀死危险的细菌。目前，这项工作正在推进这些化学物质，以创造新的、有效的抗生素，确保子孙后代能够获得这些至关重要的药物。