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CELLBLOKS - A Novel Cell Culture Device

CELLBLOKS - 一种新型细胞培养装置

基本信息

批准号：
103006
负责人：
金额：
$ 8.49万
依托单位：
REVIVOCELL LIMITED
依托单位国家：
英国
项目类别：
Feasibility Studies
财政年份：
2017
资助国家：
英国
起止时间：
2017 至无数据
项目状态：
已结题

来源：
https://gtr.ukri.org/projects?ref=103006
关键词：
CELLBLOKS Novel Cell Culture Device

项目摘要

Cell culture is a process whereby living cells are grown in laboratory conditions without using animals in order to gain better understanding of body function, disease or to develop new drugs. Traditionally, cells have been grown in hard and flat 2-D surfaces, either in glass or plastic, a technology that has not changed significantly since the invention of the Petri dish by Julius Richard Petrie in 1870s. Researchers across many sectors, including pharmaceutical industry, research organisations and universities apply conventional cell culture for the growth and testing of mammalian cells. Cell culture has played a vital role in many life science discoveries such as the development of new drugs or vaccines. However, the results often lack efficiency as cell growth is constrained within the available 2-D surface when compared to true three-dimensional (3-D) environments of living tissue. ReVivoCell Ltd is developing a novel device for the growth of cell cultures, in laboratory condition, that can mimic the function of living tissue much more closely. Existing technology for 3-D cell culture is expensive, difficult to use and not easily adaptable for different experiments and cell types. This technology would potentially increase the success rate of developing new treatments and reduce the reliance on animal testing. The objective of this project is to assess the feasibility of a newly developed 3-D cell culture device. ReVivoCell's invention will provide a reliable, fast and cost effective device that could be used worldwide.

细胞培养是一种不使用动物而在实验室条件下培养活细胞的过程，目的是更好地了解身体功能、疾病或开发新药。传统上，细胞是在坚硬而平坦的二维表面上培养的，要么是玻璃，要么是塑料。自19世纪70年代朱利叶斯·理查德·皮特里发明培养皿以来，这项技术没有发生重大变化。包括制药业、研究机构和大学在内的许多部门的研究人员将传统的细胞培养应用于哺乳动物细胞的生长和测试。细胞培养在许多生命科学发现中发挥了至关重要的作用，例如新药或疫苗的开发。然而，与活组织的真实三维(3-D)环境相比，结果往往缺乏效率，因为细胞生长被限制在可用的二维表面内。ReVivoCell有限公司正在开发一种新的设备，用于在实验室条件下进行细胞培养，可以更接近地模拟活组织的功能。现有的3D细胞培养技术昂贵、难于使用，而且不容易适应不同的实验和细胞类型。这项技术可能会提高开发新疗法的成功率，并减少对动物试验的依赖。该项目的目标是评估一种新开发的三维细胞培养设备的可行性。ReVivoCell的发明将提供一种可靠、快速和成本效益高的设备，可以在全球范围内使用。