GLAUCOMA DETECTION BY SCANNING LASER POLARIMETRY

通过扫描激光旋光法检测青光眼

• 批准号: 2165112
• 负责人: ANDREAS W DREHER
• 金额: $ 9.89万
• 依托单位: LASER DIAGNOSTIC TECHNOLOGIES, INC.
• 依托单位国家: 美国
• 财政年份: 1995
• 资助国家: 美国
• 起止时间: 1995-03-03 至 1995-09-02
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/2165112
• 关键词: biomedical equipment development; computer system design /evaluation; digital imaging; eye disorder diagnosis; glaucoma; human subject; image processing; polarimetry; retina

A new technology, scanning laser polarimetry, will be employed to measure absolute thickness of the retinal nerve fiber layer in order to detect early damage from glaucoma and other optic neuropathies. This new test is based on the polarization properties of the parallel, form- birefringent nerve fibers and can be applied through the undilated pupil. A clinical instrument has been designed that allows to measure retinal nerve fiber layer thickness at over 65,000 retinal locations in about .7 seconds. The proposed research will validate this technology by comparing the measurements with this new instrument to known properties of the human retinal nerve fiber layer and other, conventional methods of diagnosing glaucoma. The long-term goal of this research is to develop a rapid, convenient, objective screening tool for early detection and accurate follow-up of glaucoma. PROPOSED COMMERCIAL APPLICATION: Potentially, this research will lead to the development of a sensitive, easy-to-use, rapid (under 1 second), and convenient (no pupil dilation) test to diagnoses glaucoma earlier than currently possible.

一种新的技术，扫描激光偏振测量，将被用来测量 视网膜神经纤维层的绝对厚度，以检测 青光眼和其他视神经病变的早期损害。这项新测试 是基于平行的偏振特性，形式- 双折射的神经纤维，并可以通过未扩大的瞳孔应用。 设计了一种临床仪器， 在超过65，000个视网膜位置处的神经纤维层厚度约为0.7 秒拟议的研究将通过比较来验证该技术 用这种新仪器测量已知的性能， 人视网膜神经纤维层和其它常规方法 诊断青光眼。这项研究的长期目标是开发 一种快速、方便、客观的早期检测筛查工具， 青光眼的准确随访。 建议的商业应用：潜在的，这项研究将导致 开发一种灵敏、易于使用、快速（1秒以下）， 方便（无瞳孔扩张）测试，以诊断青光眼早于 目前可能。