EARLY DETECTION OF AGE RELATED MACULAR DEGENERATION

早期发现与年龄相关的黄斑变性

• 批准号: 6209957
• 负责人: ANDREAS W DREHER
• 金额: $ 40.11万
• 依托单位: LASER DIAGNOSTIC TECHNOLOGIES, INC.
• 依托单位国家: 美国
• 财政年份: 1998
• 资助国家: 美国
• 起止时间: 1998-08-01 至 2002-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6209957
• 关键词: aging; bioimaging /biomedical imaging; biomedical equipment development; clinical biomedical equipment; clinical research; computer program /software; diagnosis design /evaluation; early diagnosis; eye disorder diagnosis; human subject; image enhancement; lasers; light scattering; macular degeneration; nephelometry; noninvasive diagnosis; retina circulation; retina disorder; tomography

The long term objective of this project is to provide novel imaging instrumentation for rapid, noninvasive, and frequent measurements of retinal and subretinal changes associated with age-related macular degeneration (AMD) and age-related maculopathy (ARM). Current treatments depend upon early detection. Conventional methods either fail to provide clear-cut detection and localization, or are invasive and costly. The approach here is to integrate a multiply scattered light tomograph (MSLT) into a confocal imaging system to obtain qualitative and quantitative diagnosis of ARM and AMD. During Phase I, a prototype MSLT system was developed based on Topographic Scanning System TopSS (Laser Diagnostic Technologies, Inc.), using a Vertical Cavity Surface Emitting Laser Arrays (VCSELs) as the illumination source for both confocal imaging and multiply scattered light imaging. Clinical feasibility studies were carried out. Image acquisition software and preliminary analysis software were developed. In Phase II, we will develop a product version TopSS/MSLT system. New illumination sources will be explored to study light-tissue interactions under conditions not tested in Phase I. Extensive clinical studies will be performed at multiple sites. The software analysis tools will be developed and integrated into the MSLT instrument to measure 3-dimensional subretinal structures and their changes over time. PROPOSED COMMERCIAL APPLICATION: With the added capability of Multiply Scattered Light Tomography and its application to the detection of AMD and other retinal disease, the market for the Topographic Scanning System would vastly expend. Once we successfully implemented an automated procedure to image and quantify dmsen that leads to an early detection of AMD, an even wider use by general ophthalmologists and optometrists seems possible.

该项目的长期目标是提供新的成像仪器，用于快速、无创、频繁地测量与年龄相关性黄斑变性（AMD）和年龄相关性黄斑病变（ARM）相关的视网膜和视网膜下变化。目前的治疗依赖于早期发现。传统的方法要么不能提供明确的检测和定位，要么是侵入性的和昂贵的。本文的方法是将多重散射光断层成像（MSLT）集成到共聚焦成像系统中，以获得ARM和AMD的定性和定量诊断。在第一阶段，基于TopSS（激光诊断技术公司）的地形扫描系统开发了一个原型MSLT系统，使用垂直腔面发射激光阵列（VCSELs）作为共聚焦成像和多次散射光成像的照明源。进行了临床可行性研究。开发了图像采集软件和初步分析软件。在第二阶段，我们将开发一个产品版本的TopSS/MSLT系统。将探索新的照明源来研究在第一阶段未测试的条件下光组织相互作用。将在多个地点进行广泛的临床研究。软件分析工具将被开发并集成到MSLT仪器中，以测量三维视网膜下结构及其随时间的变化。拟议的商业应用：随着多重散射光断层扫描功能的增加及其在AMD和其他视网膜疾病检测中的应用，地形扫描系统的市场将大大扩大。一旦我们成功地实现了一种自动成像和量化dmsen的程序，从而导致AMD的早期检测，那么普通眼科医生和验光师可能会更广泛地使用它。