CONFOCAL LASER DOPPLER FLOWMETRY IN THE OPTIC NERVE

眼血流量的测量对于改善眼功能是必要的。 了解影响眼睛的几种疾病，包括 青光眼 青光眼的病因之一是青光眼的发病机制。 视神经组织由于血流不足而受损， 组织调节自身血液供应的能力不足， 对眼内压升高的反应。 临床上有用的血液 流量测量工具是必要的，以充分调查这一假设。 拟议的研究建立在本研究第一阶段发现的结果的基础上。 项目中，共焦激光多普勒血流测量装置 已经开发并被证明可以定量测量 人工诱导的血流变化。 第二阶段工作 该项目的目的是扩大视网膜区域，可以 在单次测量中进行调查，提高仪器的易用性 并研究其临床适用性， 确定（预测）影响疾病过程的程度，例如 青光眼、糖尿病视网膜病变和年龄相关性黄斑变性， 对视网膜血流的影响 拟定商业应用： 这项研究可能会导致开发一种非侵入性的， 用于视神经血流的深度分辨测量的仪器 通过未散瞳的视神经地形图 这样一项文书 在早期检测的临床领域将非常有用， 监测疾病进程及其治疗。

The measurement of ocular blood flow is essential to improve the understanding of several diseases afflicting the eye, including glaucoma. One of the hypotheses for the cause of glaucoma is that the optic nerve tissue is damaged by insufficient blood flow, because of a deficiency in the tissue's ability to regulate its own blood supply in response to increased intraocular pressure. A clinically useful blood flow measurement tool is necessary to fully investigate this hypothesis. The proposed research builds on the results found during Phase I of this project, in which a confocal laser Doppler blood flow measuring device has been developed and was shown to allow quantitative measurements of artificially induced changes in blood flow. Work during the Phase II of this project is intended to broaden the retinal area that can be investigated during a single measurement, improve the instrument's ease of use and investigate its clinical applicability by using it to determine the degree of (predicted) impact disease processes such as glaucoma, diabetic retinopathy and age related macular degeneration have on retinal blood flow. PROPOSED COMMERCIAL APPLICATION: This research may lead to the development of a non-invasive, clinical instrument for depth-resolved measurements of optic nerve bloodflow and optic nerve topography through undilated pupils. Such an instrument would be very useful in the clinical areas of early detection and monitoring of disease processes and their treatment.