CONFOCAL LASER DOPPLER FLOWMETRY IN THE OPTIC NERVE
视神经共焦激光多普勒血流测量
基本信息
- 批准号:2647996
- 负责人:
- 金额:$ 45.6万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:1996
- 资助国家:美国
- 起止时间:1996-03-20 至 2000-08-31
- 项目状态:已结题
- 来源:
- 关键词:biomedical equipment development clinical research confocal scanning microscopy diabetic retinopathy diagnosis design /evaluation eye circulation glaucoma human subject intraocular pressure macular degeneration noninvasive diagnosis ophthalmoscopy optic nerve optic nerve disorder ultrasound blood flow measurement
项目摘要
The measurement of ocular blood flow is essential to improve the
understanding of several diseases afflicting the eye, including
glaucoma. One of the hypotheses for the cause of glaucoma is that the
optic nerve tissue is damaged by insufficient blood flow, because of a
deficiency in the tissue's ability to regulate its own blood supply in
response to increased intraocular pressure. A clinically useful blood
flow measurement tool is necessary to fully investigate this hypothesis.
The proposed research builds on the results found during Phase I of this
project, in which a confocal laser Doppler blood flow measuring device
has been developed and was shown to allow quantitative measurements of
artificially induced changes in blood flow. Work during the Phase II
of this project is intended to broaden the retinal area that can be
investigated during a single measurement, improve the instrument's ease
of use and investigate its clinical applicability by using it to
determine the degree of (predicted) impact disease processes such as
glaucoma, diabetic retinopathy and age related macular degeneration have
on retinal blood flow.
PROPOSED COMMERCIAL APPLICATION:
This research may lead to the development of a non-invasive, clinical
instrument for depth-resolved measurements of optic nerve bloodflow and
optic nerve topography through undilated pupils. Such an instrument
would be very useful in the clinical areas of early detection and
monitoring of disease processes and their treatment.
眼血流量的测量对于改善眼功能是必要的。
了解影响眼睛的几种疾病,包括
青光眼 青光眼的病因之一是青光眼的发病机制。
视神经组织由于血流不足而受损,
组织调节自身血液供应的能力不足,
对眼内压升高的反应。 临床上有用的血液
流量测量工具是必要的,以充分调查这一假设。
拟议的研究建立在本研究第一阶段发现的结果的基础上。
项目中,共焦激光多普勒血流测量装置
已经开发并被证明可以定量测量
人工诱导的血流变化。 第二阶段工作
该项目的目的是扩大视网膜区域,可以
在单次测量中进行调查,提高仪器的易用性
并研究其临床适用性,
确定(预测)影响疾病过程的程度,例如
青光眼、糖尿病视网膜病变和年龄相关性黄斑变性,
对视网膜血流的影响
拟定商业应用:
这项研究可能会导致开发一种非侵入性的,
用于视神经血流的深度分辨测量的仪器
通过未散瞳的视神经地形图 这样一项文书
在早期检测的临床领域将非常有用,
监测疾病进程及其治疗。
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
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ANDREAS W DREHER其他文献
ANDREAS W DREHER的其他文献
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{{ truncateString('ANDREAS W DREHER', 18)}}的其他基金
EARLY DETECTION OF AGE-RELATED MACULAR DEGENERATION
早期发现与年龄相关的黄斑变性
- 批准号:
2650431 - 财政年份:1998
- 资助金额:
$ 45.6万 - 项目类别:
EARLY DETECTION OF AGE RELATED MACULAR DEGENERATION
早期发现与年龄相关的黄斑变性
- 批准号:
6209957 - 财政年份:1998
- 资助金额:
$ 45.6万 - 项目类别:
CONFOCAL LASER DOPPLER FLOWMETRY IN THE OPTIC NERVE
视神经共焦激光多普勒血流测量
- 批准号:
2888470 - 财政年份:1996
- 资助金额:
$ 45.6万 - 项目类别:
CONFOCAL LASER DOPPLER FLOWMETRY IN THE OPTIC NERVE
视神经共焦激光多普勒血流测量
- 批准号:
2165295 - 财政年份:1996
- 资助金额:
$ 45.6万 - 项目类别:
GLAUCOMA DETECTION BY SCANNING LASER POLARIMETRY
通过扫描激光旋光法检测青光眼
- 批准号:
2165112 - 财政年份:1995
- 资助金额:
$ 45.6万 - 项目类别:
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