CONFOCAL LASER DOPPLER FLOWMETRY IN THE OPTIC NERVE
CONFOCAL LASER DOPPLER FLOWMETRY IN THE OPTIC NERVE
批准号:
2647996
负责人:
ANDREAS W DREHER
金额:
$45.6万
依托单位国家:
美国
项目类别:
财政年份:
1996
资助国家:
美国
项目状态:
已结题
起止时间:
1996-03-20 至 2000-08-31
关键词:
biomedical equipment development clinical research confocal scanning microscopy diabetic retinopathy diagnosis design /evaluation eye circulation glaucoma human subject intraocular pressure macular degeneration noninvasive diagnosis ophthalmoscopy optic nerve optic nerve disorder ultrasound blood flow measurement
中文摘要
眼部血流量的测量是提高视力的关键。
了解几种困扰眼睛的疾病,包括
青光眼。关于青光眼病因的一个假设是
视神经组织因血流不足而受损,原因是
组织调节自身血液供应的能力不足
对眼压升高的反应。临床上有用的血液
为了充分研究这一假设,流量测量工具是必要的。
拟议的研究建立在第一阶段研究结果的基础上。
项目中,共焦激光多普勒血流测量装置
已经开发出来,并被证明允许定量测量
人为地引起血液流动的变化。第二阶段的工作
这个项目的目的是拓宽视网膜区域,可以
在单次测量期间进行调查,提高了仪器的易用性
并通过使用它来研究其临床适用性
确定(预测的)疾病进程的影响程度,例如
青光眼、糖尿病视网膜病变和老年性黄斑变性
视网膜血流量。
建议的商业应用:
这项研究可能会导致非侵入性、临床
视神经血流深度分辨测量仪
通过未扩张的瞳孔的视神经地形图。这样一种乐器
将在临床早期检测和治疗领域中非常有用
监测疾病进程及其治疗。
英文摘要
The measurement of ocular blood flow is essential to improve the
understanding of several diseases afflicting the eye, including
glaucoma. One of the hypotheses for the cause of glaucoma is that the
optic nerve tissue is damaged by insufficient blood flow, because of a
deficiency in the tissue's ability to regulate its own blood supply in
response to increased intraocular pressure. A clinically useful blood
flow measurement tool is necessary to fully investigate this hypothesis.
The proposed research builds on the results found during Phase I of this
project, in which a confocal laser Doppler blood flow measuring device
has been developed and was shown to allow quantitative measurements of
artificially induced changes in blood flow. Work during the Phase II
of this project is intended to broaden the retinal area that can be
investigated during a single measurement, improve the instrument's ease
of use and investigate its clinical applicability by using it to
determine the degree of (predicted) impact disease processes such as
glaucoma, diabetic retinopathy and age related macular degeneration have
on retinal blood flow.
PROPOSED COMMERCIAL APPLICATION:
This research may lead to the development of a non-invasive, clinical
instrument for depth-resolved measurements of optic nerve bloodflow and
optic nerve topography through undilated pupils. Such an instrument
would be very useful in the clinical areas of early detection and
monitoring of disease processes and their treatment.
期刊论文(0)
专著(0)
科研奖励(0)
会议论文
EARLY DETECTION OF AGE-RELATED MACULAR DEGENERATION
-
批准号:2650431
-
项目类别:
-
资助金额:$9.92万
-
财政年份:1998
-
负责人:ANDREAS W DREHER
-
依托单位:
EARLY DETECTION OF AGE RELATED MACULAR DEGENERATION
-
批准号:6209957
-
项目类别:
-
资助金额:$40.11万
-
财政年份:1998
-
负责人:ANDREAS W DREHER
-
依托单位:
SOFTWARE FOR DIGITAL OPTIC DISC CHANGE DETECT
-
批准号:2020317
-
项目类别:
-
资助金额:$9.93万
-
财政年份:1997
-
负责人:ANDREAS W DREHER
-
依托单位:
CONFOCAL LASER DOPPLER FLOWMETRY IN THE OPTIC NERVE
-
批准号:2888470
-
项目类别:
-
资助金额:$29.39万
-
财政年份:1996
-
负责人:ANDREAS W DREHER
-
依托单位:
CONFOCAL LASER DOPPLER FLOWMETRY IN THE OPTIC NERVE
-
批准号:2165295
-
项目类别:
-
资助金额:$9.62万
-
财政年份:1996
-
负责人:ANDREAS W DREHER
-
依托单位:
GLAUCOMA DETECTION BY SCANNING LASER POLARIMETRY
-
批准号:2165112
-
项目类别:
-
资助金额:$9.89万
-
财政年份:1995
-
负责人:ANDREAS W DREHER
-
依托单位:
SCANNING LASER TOMOGRAPHY OF THE HUMAN CORNEA
-
批准号:2164359
-
项目类别:
-
资助金额:$8.08万
-
财政年份:1994
-
负责人:ANDREAS W DREHER
-
依托单位:
海外基金