EARLY DETECTION OF AGE-RELATED MACULAR DEGENERATION

早期发现与年龄相关的黄斑变性

• 批准号: 2650431
• 负责人: ANDREAS W DREHER
• 金额: $ 9.92万
• 依托单位: LASER DIAGNOSTIC TECHNOLOGIES, INC.
• 依托单位国家: 美国
• 财政年份: 1998
• 资助国家: 美国
• 起止时间: 1998-08-01 至 1999-01-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/2650431
• 关键词: aging; anatomy; biomedical equipment development; clinical biomedical equipment; clinical research; computer program /software; diagnosis design /evaluation; early diagnosis; eye disorder diagnosis; human subject; image enhancement; lasers; light scattering; macular degeneration; macular drusen; retina disorder; tomography

DESCRIPTION: The long term objective of this project is to provide an instrumentation for diagnosing and quantification of the retinal changes associated with age-related macular degeneration (ARM) and age related maculopathy (AMD). The approach employed here is to integrate a multiply scattered light imaging mechanism into a confocal imaging system to obtain qualitative and quantitative diagnosis of subretinal structures and their changes. The system to be developed will be based on a Topographic Scanning System TopSSTM (Laser Diagnostic Technologies, Inc.). Vertical Cavity Surface Emitting Laser Arrays (VCSELs) will be implemented to provide an illumination source for both confocal imaging mode and multiply scattered light imaging mode. Phase I work of this project will start with hardware modifications of the existing TopSSTM system to implement the multiply scattered light imaging mode; clinical studies will then be carried out to test the feasibility of diagnosing subretinal changes associated with ARM and AMD using the modified TopSSTM system; software for measurement of the 3-dimensional subretinal structure and quantification of their changes will also be developed. PROPOSED COMMERCIAL APPLICATION: NOT AVAILABLE

描述：该项目的长期目标是提供一个 用于诊断和定量视网膜变化的仪器 与年龄相关的黄斑变性（ARM）和年龄相关的 黄斑病变（AMD）。 这里采用的方法是将一个乘法 将散射光成像机构引入共焦成像系统中，以获得 视网膜下结构的定性和定量诊断及其 变化 将开发的系统将基于地形 扫描系统TopSSTM（Laser Diagnostic Technologies，Inc.）垂直 腔面发射激光器阵列（VCSEL）将被实施， 为共焦成像模式和多重成像模式提供照明源 散射光成像模式。 该项目的第一阶段工作将从硬件修改开始， 现有的TopSSTM系统来实现多重散射光成像 模式;然后将进行临床研究，以测试 使用该方法诊断与ARM和AMD相关的视网膜下变化 修改后的TopSSTM系统;用于测量三维的软件 视网膜下结构及其变化的定量也将被 开发 拟议商业应用：不可用