Affordable cryo-EM (FEG-TEM Upgrade)

YPS打算为基于热离子的透射电子显微镜(TEM)开发一种专门制造的升级解决方案。该产品将利用电子能量为100keV的场发射源，将源亮度提高至少500倍。这将使那些买不起高端低温电子显微镜的用户有机会扩展他们现有仪器的能力，而成本只有高端瞬变电子显微镜的一小部分。YPS将与世界著名的医学研究理事会分子生物学实验室(MRC-LMB)合作，该实验室拥有大量的低温EM用户和专业知识，并将指导整个开发。这种参与将确保充分满足最终用户对这类技术的需求。同样重要的是，他们的参与将成为验证已开发技术的一种手段。YPS专门从事场发射电子源(热型和冷型)的制造，并在全球分销，并开发高端电子显微镜的新型解决方案。此外，YPS还制造用于电子束仪器的场发射枪(FEG)、高压EHT单元和馈线。YPS已经成功地开发和展示了将基于热离子的扫描电子显微镜(SEM)升级为FEG类型的技术，从而显著提高了它们的分辨率和低电压操作，这对用于辐射敏感材料和纳米技术材料的检测是有用的。

YPS intends to develop a purpose built upgrade solution for a thermionic based transmission electron microscope (TEM). This product will utilise a field emission source at an electron energy of 100 keV that will improve the source brightness by at least 500x. This will allow users who are unable to afford a high-end cryoEM the opportunity to extend the capabilities of their existing instruments at a fraction of the cost of a high-end TEM. YPS will partner with the world-renowned Medical Research Council Laboratory of Molecular Biology (MRC-LMB), which has a large concentration of cryoEM users and expertise and who will guide the overall development. This involvement will ensure that the needs of end-users for such technology are adequately met. Equally as important, their involvement will serve as a means to validate the developed technology. YPS specialise in the manufacture of field emission electron sources (thermal and cold type), which it distrbutes world-wide, and the development of novel solutions for high-end electron microscopy. In addition, YPS also manufacture field emission guns (FEG), high voltage EHT units and feedthroughs for electron beam based instruments. YPS has successfully developed and demonstrated technology to upgrade thermionic-based scanning electron microscopes (SEMs) to FEG types, thus significantly improving their resolution and low voltage operation which is useful to use in the inspection of radiation sensitive and nanotechnology materials.