Lactam based biofilm-ready surfaces with cross-industry application

具有跨行业应用的内酰胺基生物膜就绪表面

• 批准号: 103978
• 金额: $ 53.05万
• 依托单位: UNILEVER U.K. CENTRAL RESOURCES LIMITED
• 依托单位国家: 英国
• 项目类别: Collaborative R&D
• 财政年份: 2017
• 资助国家: 英国
• 起止时间: 2017 至 无数据
• 项目状态: 已结题
• 来源: https://gtr.ukri.org/projects?ref=103978
• 关键词: Lactam; based; biofilm; ready; surfaces

Hygiene in homecare, paper and marine industries is increasingly challenging. Home, industrial, hospital and marine surfaces are constantly challenged by microbial contamination. Current anti-microbials such as metals and quats present environmental and toxicological risks, are of limited efficacy on biofilms, whilst presenting a risk of increasing microbial resistance. Bioderived lactams disrupt quorum sensing during biofilm growth and development apparently without driving resistance. Recent feasibility work demonstrated the potential of lactams as anti-biofilm coatings on textiles (TSB132177). To date, their efficacy as active ingredients in liquid products is limited due to bioavailability and formulation hurdles. Using diverse application techniques during manufacture and finishing, lead analogues will be localised on wipes, paper, marine, and other industrial surfaces. The project will build a business case and recommend efficient incorporation chemistry and process route for cross-industry surface biofilm disruption based on cost, efficacy and robustness. Successful demonstration of application will fast track lactam commercialisation allowing market share and revenue gains for industrial partners and IP and publication monetisation for ROs.

家庭护理、造纸和海洋行业的卫生越来越具有挑战性。家庭、工业、医院和海洋表面不断受到微生物污染的挑战。目前的抗微生物剂如金属和季铵盐存在环境和毒理学风险，对生物膜的功效有限，同时存在增加微生物抗性的风险。生物衍生的内酰胺在生物膜生长和发育过程中明显地破坏群体感应，而没有驱动抗性。最近的可行性研究证明了内酰胺作为纺织品抗生物膜涂层的潜力（TSB 132177）。迄今为止，由于生物利用度和制剂障碍，它们作为液体产品中的活性成分的功效有限。在制造和加工过程中使用不同的应用技术，铅类似物将局限于擦拭物，纸张，海洋和其他工业表面。该项目将建立一个商业案例，并根据成本、功效和稳健性，为跨行业的表面生物膜破坏推荐有效的结合化学和工艺路线。成功的应用示范将加快内酰胺的商业化，为工业合作伙伴带来市场份额和收入增长，为RO带来知识产权和出版物货币化。